OOLONG tea may reduce neuroinflammation by modulating the microbiota-gut-brain axis, according to findings from a rat model of autism.
Researchers investigated the effects of oolong tea on behavioral changes, neuroinflammatory responses, and gut microbiota composition in rats exposed to valproic acid, a model used to mimic features of autism spectrum disorder. The study aimed to better understand whether dietary components can influence brain function through microbiota interactions.
Results showed that oolong tea supplementation improved behavioral performance in the rats, including social interaction and reduced anxiety-like activity. These changes were accompanied by decreases in neuroinflammatory markers, suggesting a protective effect on brain tissue.
Analysis of the gut microbiota revealed that oolong tea altered microbial composition and diversity in the rats. The intervention appeared to restore balance in bacterial populations that had been disrupted in the autism model, supporting the concept that modulation of the microbiota is linked to neuroinflammatory control.
In addition, oolong tea influenced metabolic pathways associated with microbial function, including those involved in amino acid and neurotransmitter regulation. This points to a potential mechanism where dietary intervention supports brain health by reshaping the gut ecosystem.
The findings suggest that oolong tea may offer therapeutic potential by targeting the microbiota-gut-brain axis. While the study was limited to a preclinical model, the results highlight the importance of exploring dietary strategies as adjunctive approaches for neurological and developmental conditions. Further studies will be needed to determine whether these findings translate to human populations and to clarify safe and effective intake levels.
Reference: Brooks M et al. Oolong tea attenuates neuroinflammation by modulating the microbiota-gut-brain axis in a rat model of autism. 2025. doi:10.1093/cid/ciaf490
