Targeting Brain Metastases: Intracranial Activity of Zongertinib in HER2 (ERBB2)-Mutant NSCLC - European Medical Journal

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Targeting Brain Metastases: Intracranial Activity of Zongertinib in HER2 (ERBB2)-Mutant NSCLC

Oncology

The publication of this infographic was funded by Boehringer Ingelheim. This content is intended for US Healthcare Professionals.

Disclaimer: Zongertinib is a tyrosine kinase inhibitor (TKI) that selectively inhibits HER2 (ERBB2). This orally administered, targeted therapy was approved as HERNEXEOS® (zongertinib tablets) under the FDA’s Accelerated Approval Program, after securing Priority Review as well as Breakthrough Therapy and Fast Track Designations. Please see full for HERNEXEOS.

In HER2 (ERBB2)-mutant NSCLC, brain metastases present a significant unmet need. Read this infographic to explore the intracranial activity of zongertinib and its systemic efficacy and safety in patients with and without brain metastases at baseline.

Uncover:

  • How common are brain metastases in HER2-mutant NSCLC?
  • Does zongertinib provide intracranial response without prior brain radiotherapy?
  • How consistent is systemic activity in patients with and without brain metastases?
  • What does the safety profile look like in patients with stable, asymptomatic brain metastases?

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