SOLID pseudopapillary neoplasm prognostic nomogram development has demonstrated strong predictive accuracy for overall survival, offering clinicians a validated tool to guide treatment decisions in a rare pancreatic tumour.
Solid pseudopapillary neoplasm of the pancreas is an uncommon malignancy, and the limited availability of prognostic models has posed challenges for clinicians managing these patients.
In this study, data were obtained from individuals diagnosed between 2000–2018 using a large population-based registry and divided into training and validation cohorts at a ratio of 7:3.
Researchers applied Cox regression analysis to identify independent prognostic factors associated with overall survival. The findings revealed that total positive lymph nodes, age, surgery type, and summary stage were all independently associated with survival outcomes and were subsequently incorporated into the solid pseudopapillary neoplasm prognostic nomogram.
Validation And Predictive Performance
The solid pseudopapillary neoplasm prognostic nomogram underwent rigorous internal validation. Predictive performance was assessed using concordance index, area under the curve, calibration curves, and decision curve analysis. The concordance index values were high across cohorts, indicating strong discrimination: 0.927 in the training cohort and 0.93 in the internal validation cohort.
External validation was conducted using institutional data collected between January 2008 and January 2026, further confirming the robustness of the model with a concordance index of 0.965.
The area under the curve values exceeded 0.7, supporting good discriminative ability. Calibration curves demonstrated close agreement between predicted and observed survival outcomes, reinforcing the reliability of the model in clinical settings.
Clinical Utility of the Nomogram
Decision curve analysis highlighted the clinical effectiveness of the solid pseudopapillary neoplasm prognostic nomogram, showing meaningful net benefit across a range of clinical scenarios.
These findings suggest that the model may support clinicians in stratifying risk and tailoring treatment strategies more precisely.
Overall, this validated nomogram represents a significant advancement with regard to prognostic assessment in patients with solid pseudopapillary neoplasm. By integrating key clinical and pathological variables, it provides an evidence-based approach to predicting overall survival and may enhance decision-making in both surgical and oncological care pathways.
Reference
Zhong P et al. Development and validation of a nomogram for overall survival in pancreatic solid pseudopapillary neoplasm: a population-based study. Scientific Reports. 2026; https://doi.org/10.1038/s41598-026-47722-0.
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