What Will the Next Decade of HER2-Targeted Therapy Look Like? - European Medical Journal

What Will the Next Decade of HER2-Targeted Therapy Look Like?

Oncology

Onc Now | Episode 24

In this episode of Onc Now, host Jonathan Sackier welcomes Komal Jhaveri, Breast Medical Oncologist and clinical investigator at Memorial Sloan Kettering Cancer Center, New York, USA. Known for her trailblazing work in HER2-positive, HER2-low, and hormone receptor-positive breast cancers, Komal Jhaveri discusses how molecular subtyping, antibody-drug conjugates, and precision trials are reshaping the field. 

 

Komal Jhaveri, Breast Medical Oncologist and Clinical Investigator at Memorial Sloan Kettering Cancer Center, New York, USA.

 

Komal Jhaveri is a Breast Medical Oncologist and Clinical Investigator at Memorial Sloan Kettering Cancer Center, New York, USA. Her research focuses on precision oncology, with a particular emphasis on HER2-positive, HER2-low, and hormone receptor-positive breast cancers. She has led and contributed to numerous landmark trials that have shaped current treatment standards and is actively involved in the development of next-generation targeted therapies, including antibody-drug conjugates. 

 

Timestamps 

00:00 – Introduction 

02:50 – What initially drew Komal into oncology  

04:45 – The future of breast cancer care 

06:13 – Possibility of personalised treatments for patients 

07:40 – Antibody-drug conjugates 

09:30 – How we define HER2 status 

14:40 – HER2-low disease 

17:40 – Targeted therapy combinations 

20:54 – Endocrine resistance 

23:18 – The realities of implementing new therapies  

28:40 – Promising initiatives on the horizon 

31:30 – Komal’s key takeaways  

 

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