A Retrospective Study Identifying Factors Associated with Long-Term Survival in Lung Transplant Recipients: A Focus on Psychosocial Wellbeing and Social Determinants of Health - European Medical Journal

A Retrospective Study Identifying Factors Associated with Long-Term Survival in Lung Transplant Recipients: A Focus on Psychosocial Wellbeing and Social Determinants of Health

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Respiratory
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Authors:
* Eric Huang , 1 Cassie Kennedy , 2 Sahar Saddoughi , 3 Hemang Yadav , 2 Kelly Pennington 2
*Correspondence to [email protected]
Disclosure:

The authors have declared no conflicts of interest.

Citation:
Respir AMJ. ;3[1]:52-53. https://doi.org/10.33590/neurolamj/FAJF6685.
Keywords:
Area Deprivation Index (ADI), housing-based socioeconomic status (HOUSES) index, long-term survival, lung transplant, Psychosocial Assessment of Candidates for Transplantation (PACT) score, psychosocial wellness, social determinants of health.

Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.

BACKGROUND

Long-term survival after lung transplantation remains challenging, with limited research on risk and protective factors. The role of psychosocial wellness and socioeconomic status (SES) are particularly understudied. This study evaluated the impact of pre-transplant surrogate markers of psychosocial health and SES on long-term survival in adult lung transplant recipients.

METHODS

The authors conducted a single-center, retrospective case-control study using the Mayo Clinic lung transplant registry. Cases (survival >6 years) and controls (survival <6 years) were matched by transplant date (±5 years) and indication for transplant, resulting in 190 subjects (63 cases and 127 controls).

Psychosocial health was assessed using the Psychosocial Assessment of Candidates for Transplantation (PACT) score (1–4 scale; ≥2 ultimately required for transplant). Additional variables included proximity to the transplant center, insurance type, marital status, caregiver status, and employment. SES was estimated using two address-based markers: the housing-based SES (HOUSES) index (a novel composite score derived from various housing characteristics where higher scores equal better SES) and the Area Deprivation Index (ADI) at national and state levels (higher scores equal greater deprivation).

Statistical analysis used paired Wilcoxon rank-sum and McNemar’s tests. Results were reported as medians or percentages.

RESULTS

Preliminary data demonstrated that PACT scores and other psychosocial variables had no significant differences between groups. HOUSES index scores were similar (p=0.179), but long-term recipients had significantly higher ADI scores (national: p=0.029; state: p=0.019). Other variables relating to donor and recipient characteristics showed no significant differences (all p>0.05; Table 1).

Table 1: Evaluation of risk factors associated with long-term lung transplant survival.
*p<0.05
ADI: Area Deprivation Index; HOUSES: housing-based socioeconomic status; IQR: interquartile range; PACT: Psychosocial Assessment of Candidates for Transplantation.

CONCLUSION

Pre-transplant psychosocial health indicators, including PACT scores, caregiver support, marital status, and proximity to transplant centers, were not linked to long-term survival.

While the HOUSES index was not associated with long-term survival, higher ADI scores correlated with improved survival, suggesting unique protective factors in socioeconomically disadvantaged populations. These findings highlight the complex role of socioeconomic factors in lung transplant outcomes and underscore the need for further research into how specific socioeconomic and environmental factors influence long-term survival.

References
Huang E et al. A retrospective study identifying factors associated with long-term survival in lung transplant recipients: a focus on psychosocial wellbeing and social determinants of health. Abstract P1271. ATS International Conference, 18-21 May, 2025.

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