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Chronic Active Antibody-mediated Rejection in Renal Transplant Recipients
2
Mins
April 2024
In 2022, over 92,000 kidney transplants were performed globally.1 With advancements in transplant science, 1-year graft survival rates…
Read more
2
Mins
4th April 2024
Chronic Active Antibody-mediated Rejection in Renal Transplant Recipients
In 2022, over 92,000 kidney transplants were performed globally.1 With advancements in transplant science, 1-year graft survival rates…
7
Mins
14th March 2024
Sparsentan for treatment of immunoglobulin A nephropathy: Latest study results
In patients with immunoglobulin A nephropathy, use of the endothelin 1 Type A/Ang II subtype 1 receptor antagonist sparsentan can decrease proteinuria and preserve kidney function
8
Mins
14th March 2024
Renal Replacement Therapy
End-stage liver disease (ESLD) represents a non-reversible, advanced stage of cirrhosis, where the hepatic architecture is distorted and…
8
Mins
7th March 2024
Interview: Smeeta Sinha
Smeeta Sinha National Clinical Director for Renal Medicine, NHS England, UK; Consultant Nephrologist, Northern Care Alliance NHS Foundation…
4
Mins
16th February 2024
Membranous Nephropathy and Pulmonary Tuberculosis
Mycobacterium tuberculosis causing glomerulonephritis (GN) is a rare occurrence, and its association has been seldom reported…
10
Mins
14th December 2023
Current Treatment and Emerging Solutions in IgA Nephropathy
IgAN, which can lead to CKD and kidney failure, is the most common form of primary glomerulonephritis, predominantly…
12
Mins
15th August 2023
Diagnosing Fabry Disease: Practical Clinical Recommendations and Guidance for Patients with Fabry Disease
This article was funded by Sanofi and is intended for healthcare professionals.
10
Mins
27th July 2023
Filling the Gap by Targeting the Gut: First Disease-Modifying Treatment Approved for IgA Nephropathy
Bengt Fellström, Uppsala University, Sweden, described the relationship between IgA nephropathy (IgAN) and gastrointestinal mucosal…
5
Mins
27th July 2023
Proteinuria as a Surrogate Endpoint for Disease Progression in IgA Nephropathy: Predicting Long-Term Treatment Effects of Sparsentan
IgA nephropathy (IgAN) is a rare, life-limiting disease for which there is significant unmet need. Until recently, drug development for…
8
Mins
27th July 2023
Interview: Catherine Quinlan
I only ever wanted to be a paediatrician, thanks to ER’s Doug Ross, and my first job was on the nephrology service in Temple Street…
11
Mins
27th July 2023
Recent Advances in Targeting Complement in Glomerular Disease
The complement system has been an appealing drug target for a long time. However, early drug development efforts have failed for…
10
Mins
27th July 2023
The Effect of Tip Placement on Fibrin Sheath Formation in Poorly Functioning Tunnelled Haemodialysis Lines
One of the most common causes of a poorly functioning haemodialysis (HD) line is the formation of a fibrin sheath. Tunnelled HD lines contain a Dacron® (Invista, Wichita, Kansas, USA) cuff at the skin entry site, which helps secure the catheter in place due to the fibrosis that occurs in the subdermal tissues.
6
Mins
19th July 2023
Steroid-Dependent Nephrotic Syndrome in a Child After an Allogeneic Bone Marrow Transplant: A Case Report
The authors present a case report of a child presenting with difficult-to-manage, steroid-sensitive, frequently relapsing nephrotic…
5
Mins
14th July 2023
A Case Control Study of Mesoamerican Nephropathy in Farmers with Long-Term Exposure to Agrochemical Compounds in El Salvador
Chronic kidney diseases (CKD) are very prevalent in Central America, particularly in El Salvador. Mesoamerican nephropathy (MN) is a CKD diagnosis that almost exclusively affects young male agricultural labourers.
16
Mins
14th June 2023
Anaemia of Chronic Kidney Disease: Aligning Patient and Physician Awareness - Interviews with Three Key Opinion Leaders and Patient Advocates
Anaemia is a common and serious complication of chronic kidney disease (CKD) that can greatly impact the daily lives of patients. However…
8
Mins
6th June 2023
Editor's Pick: Relationships of Chronic Kidney Disease and Thyroid Dysfunction in Patients with Stage 4 and 5 Chronic Kidney Disease: A Cross-Sectional Study
A spectrum of various pathophysiological processes associated with a progressive worsening in estimated glomerular filtration rate (eGFR)…
8
Mins
17th May 2023
Interview: Matthew A. Sparks
Growing up, I didn’t have much exposure to medicine. There were no physicians, or even anyone in science, in my family, including…
5
Mins
9th May 2023
Interview: Sam Kant
I always enjoyed science and being part of a bigger community. Medicine combines these two aspects really well. I pursued nephrology…
12
Mins
16th March 2023
Ocedurenone: A Novel Therapy for Uncontrolled Hypertension in Advanced Chronic Kidney Disease
Setting the scene, Bakris defined CKD as a reduction in kidney function (estimated glomerular filtration rate [eGFR] <60 mL/min/1.73 m2), alongside the presence of albuminuria (≥30 mg/day) as an indication of kidney damage.
14
Mins
10th March 2023
Editor's Pick: Metabolic Acidosis in Children: A Literature Review
Metabolic acidosis is characterised by a primary decrease in the serum bicarbonate concentration, a secondary decrease in the arterial partial pressure of CO2, and a reduction in blood pH. Metabolic acidosis, acute or chronic, may have deleterious effects on cellular function and cause increased morbidity and mortality.
11
Mins
16th January 2023
Editor's Pick: Hypertension in Patients Receiving Dialysis: A Review of the Current Clinical Approach
Hypertension is a common complication in advanced chronic kidney disease (CKD), occurring in approximately 80–85% of patients. Blood…
10
Mins
19th December 2022
Prevalence of SARS-CoV-2 Cellular and Humoral Immunity Amongst Patients on Dialysis After the First Vaccination Campaign
Global immunisation against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the standard-of-care in preventing COVID-19…
5
Mins
20th September 2022
Marfan Syndrome and Autosomal Dominant Polycystic Kidney Disease: A Case of Rare Co-occurrence or Coincidence?
Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder with an incidence of 1 in 3,000–5,000.
11
Mins
20th September 2022
Findings and Implications of the REVEAL-CKD Study Investigating the Global Prevalence of Undiagnosed Stage G3 Chronic Kidney Disease
Chronic kidney disease (CKD) is a progressive condition that can lead to kidney failure and the requirement for renal dialysis or transplantation. Early-stage CKD is often missed because the disorder is initially asymptomatic; hence, many patients with CKD already have symptomatic advanced disease (Stages G4–G5) at the time of diagnosis. This is an important issue because the drugs available for the treatment of CKD are most effective when given during the early stages of the disease (Stages G1–G3).
8
Mins
2nd September 2022
Update on New Antigens in the Pathogenesis of Membranous Nephropathy
Previously, membranous nephropathies were divided into primary and secondary categories when the exact mechanism or pathogenetic factor were unknown. Approximately 70% accounted for primary membranous nephropathies. The remaining 30% were called secondary because they developed due to well-known diseases such as autoimmune diseases, tumours, infections, or drug assumptions.
12
Mins
30th June 2022
The Dual Role of Endothelin-1 and Angiotensin II in Disease Progression of Focal Segmental Glomerulosclerosis and IgA Nephropathy
This article details the diagnosis and treatment of IgA nephropathy and focal segmental glomerulosclerosis, as discussed in a symposium delivered as part of the European Renal Association (ERA) 59th Congress in Paris, 19th−22nd May 2022.
11
Mins
30th June 2022
Medium Cut-off Delivering Expanded Haemodialysis Therapy: Improving Clinical and Economic Outcomes in the Real World
In this symposium, the pathological background of the association between the uremic milieu and inflammation and pathways for poor outcomes in patients on haemodialysis (HD)
4
Mins
30th June 2022
Interview: John Sperati
Talking to John Sperati, Director of Nephrology Fellowship Training Program and Associate Professor of Medicine at Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
4
Mins
30th June 2022
The Ground Is Full of Pitfalls: Association of Chronic Kidney Disease, Conflict Zones, and the Quality of Healthcare in Africa
Public health in sub-Saharan African countries is experiencing a double burden of diseases. Unfortunately, the health systems in sub-Saharan Africa are vulnerable, under-resourced, and unable to address these public health issues.
6
Mins
30th June 2022
Interview: Vivek Bhalla
The primary reason is that it’s the most impactful disease that affects nephrology. When I was in training, there was only one medicine…
5
Mins
30th June 2022
Focal Segmental Glomerulosclerosis: Histopathology Discussion
In focal segmental glomerulosclerosis (FSGS), some (not all) glomeruli are affected with sclerosis (focal), and each diseased glomerulus…
6
Mins
30th June 2022
Editor’s Pick: The Renal Effects of SGLT2 Inhibitors
Sodium–glucose co-transporters (SGLT) play an important role in glucose transport across epithelial cells. SGLT1….
6
Mins
30th June 2022
COVID-19-Associated Nephropathy: An Emerging Clinical Entity
In this article, the authors present the pathophysiology behind SARS-CoV-2-related kidney involvement and the development of COVID-19-associated nephropathy.
9
Mins
30th June 2022
Low-Dose Dopamine in the Management of Intradialysis Hypotension: A Retrospective Cohort Study in Nigeria
Intradialysis hypotension (IDH) commonly complicates haemodialysis treatment, and could be associated with dysfunction…
10
Mins
30th June 2022
Pathophysiology of Diabetic Kidney Disease
Diabetic kidney disease (DKD) has been an immense burden on the healthcare system, and is the leading cause of end stage kidney disease…
6
Mins
30th June 2022
SGLT2 Inhibitors for Nephrologists
Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers are the mainstay of therapy for…
3
Mins
22nd March 2022
Epidermodysplasia Verruciformis in a Patient with a Renal Transplant: A Rare Case Report
Acquired Epidermodysplasia Verruciformis is a rare entity associated with immunodeficiency, such as kidney transplant patients…
11
Mins
17th March 2022
Improving Outcomes for Haemodialysis Patients: Sizing Up the Problem – Interviews with Two Key Opinion Leaders
Despite recent developments in renal medicine, mortality rates remain high in patients receiving long-term haemodialysis (HD) due to…
12
Mins
25th November 2021
Chronic Kidney Disease-Associated Pruritus: From Epidemiology to Treatment
Chronic kidney disease-associated pruritus (CKD-aP) occurs in over two-thirds of patients undergoing haemodialysis. The aetiology of CKD-aP may be multifactorial, involving immune system and opioid dysregulation, peripheral neuropathy, and toxin deposition. CKD-aP can be extremely bothersome for some patients, affecting health-related quality of life and sleep, as well as increasing the likelihood of hospitalisation, infections, and death.
10
Mins
25th October 2021
Epidermal Growth Factor Receptor Inhibitor-Induced Hypomagnesaemia: Is There a Best Replacement Strategy?
Over the past few decades, there have been important advances in cancer therapeutics, including a shift from traditional cytotoxic…
16
Mins
12th October 2021
Improving Knowledge in ANCA-Associated Vasculitis: What Do Patients and Doctors Think? Interviews with Two Opinion Leaders and Two Patient Representatives
AAV is a rare and severe multisystem disease affecting the small arteries.1,2 The condition is characterised by systemic inflammation across multiple body sites including the lungs, joints, kidneys, nerves, ears, and nose.1,2 Glucocorticoids and immunosuppressants form the cornerstone of current treatment approaches.
11
Mins
13th August 2021
Unmet Medical Needs in Chronic-Kidney-Disease-Associated Pruritus
CKD-aP necessitates a differential diagnosis to ascertain that the itching a patient is experiencing is related to…
7
Mins
20th July 2021
Secondary Hyperparathyroidism in Non-dialysis Chronic Kidney Disease
Chronic kidney disease can result in morbidity and mortality not only due to renal dysfunction itself, but also to associated…
5
Mins
20th July 2021
INTERVIEW: KENAR D. JHAVERI
Kenar D. Jhaveri | Professor of Medicine and Associate Chief in the Division of Kidney Diseases and Hypertension, Hofstra/Northwell School of Medicine, Hempstead, New York, USA
8
Mins
20th July 2021
Editor’s Pick: Blood Volume Monitoring: A Clinical Tool to Guide Ultrafiltration in Volume Control and Optimisation of Intradialytic Blood Pressure
The use of BVM dates back to the early 1990s when CRIT-LINE® technology (Fresenius Medical Care, Bad Homburg, Germany) was first used as a non-invasive method of measuring haematocrit changes during haemodialysis, in real time, by connection of an additional monitor to the dialysis arterial line set-up.
9
Mins
20th July 2021
Idefirix® (Imlifidase): A Paradigm Shift in Transplanting the Untransplantable?
Imlifidase was granted a conditional marketing authorisation by the European Commission in August 2020 for “desensitisation treatment of highly sensitised adult kidney transplant patients with positive crossmatch against an available deceased donor.”36 This milestone launched a new era in kidney transplantation for selected patients who would previously have remained untreated.
11
Mins
20th July 2021
Trace Elements and Chronic Kidney Disease: A Cross-Sectional Study from Jamaica
Trace elements are ubiquitous entities and a fair number of non-essential xenobiotics gain entry into the body via a multitude of ways, including through groundwater (arsenic, strontium, silicon), inhalation of silica dust (silicon), gasoline (lead), cigarette smoke, and soil (cadmium) and food contamination (arsenic, mercury).
8
Mins
20th July 2021
INTERVIEW: ROBERT JOHN UNWIN
Interview with Robert John Unwin | Professor Emeritus of Nephrology, former Professor of Nephrology and Physiology, University College London, UK; Scientific Advisory Board member of ERA-EDTA
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