European Archives - European Medical Journal

Scientists Rethink the Biological Drivers of Severe Asthma

Scientists Rethink the Biological Drivers of Severe Asthma

Mean urinary concentrations of two pseudo leukotrienes were elevated four- to five-fold in individuals with severe asthma compared with controls (P=0.004 and P=0.0015).

Artificial Urinary Sphincter Demonstrates Strong Efficacy and Safety

Artificial Urinary Sphincter Demonstrates Strong Efficacy and Safety

A multicentre prospective trial shows the artificial urinary sphincter delivers high continence rates, improved quality of life, and a low revision rate in men.

Sex Differences in Alzheimer’s Disease Biomarkers at Age 60

Sex Differences in Alzheimer’s Disease Biomarkers at Age 60

New imaging data reveal striking sex differences in Alzheimer’s disease biomarkers, with implications for diagnosis and personalised dementia care.

Human Parvovirus B19 Drives Bone Marrow Failure

Human Parvovirus B19 Drives Bone Marrow Failure

Parvovirus B19 was shown to infect haematopoietic stem cells, impairing self renewal and differentiation, with JAK2 STAT5 inhibition partially reversing virus induced bone marrow dysfunction.

Repeat Influenza Vaccination May Blunt Early Immunity

Repeat Influenza Vaccination May Blunt Early Immunity

How does repeat influenza vaccination affect antibody responses? Study finds early immune boosts may be smaller, but protection later remains similar.

New Global Strategy Targets Gaps in Fertility Care Access

New Global Strategy Targets Gaps in Fertility Care Access

A new global strategy calls for infertility care to be integrated into reproductive health systems to improve access and equity worldwide.

Bimekizumab Shows Durable Long-Term Psoriasis Clearance

Researchers identified a distinct population of tissue-resident memory T (TRM) cells expressing IL-17A and/or IL-17F that were largely absent from healthy skin.

Early-Life Sugar Rationing Reduced Heart Failure Risk - EMJ

Early-Life Sugar Rationing Reduced Heart Failure Risk

Those exposed to early-life sugar rationing had an approximately 14% lower risk of developing heart failure and were diagnosed an average of 2.6 years later than individuals who were unexposed.

Risankizumab Shows Long-Term Psoriasis Benefits on OCT - EMJ

Optical Coherence Therapy Reveals Subclinical Benefits of Risankizumab in Psoriasis

A 52-week study shows risankizumab improves both visible psoriasis and underlying vascular inflammation, with OCT revealing sustained subclinical skin changes.

Brains Reward Circuitry Boosts Immune Function - EMJ

Can the Brain's Reward Circuitry Boost Immune Function?

Notably, higher ventral tegmental area (VTA) activation, but not nucleus accumbens or control region activity, correlated with larger post-vaccination increases in HBV antibody levels (r=0.31, P=0.018)