European Archives - Page 1004 of 1334 - European Medical Journal

Editor's Pick: Allogeneic Haematopoietic Stem Cell Transplantation for Chronic Myeloid Leukaemia in the Era of Tyrosine Kinase Inhibitors

The introduction of tyrosine kinase inhibitors (TKI) has dramatically improved the prognosis of chronic myeloid leukaemia (CML) patients and, therefore…

Inherited Platelet Disorders Caused by Thrombopoietin Mutation

Thrombopoietin (THPO) and the interaction with its receptor c-Mpl have a nonredundant role in platelet biogenesis and maintenance of the haematopoietic…

Therapeutic Options in Myelodysplastic Syndromes: Established and Emerging Therapies

Although hypomethylating agents (HMA) have revolutionised the treatment of myelodysplastic syndromes (MDS), a significant proportion of patients either…

Bacterial Contamination of Platelet Transfusion Units Affects Platelet Haemostatic Function and Immunological Activity

Transfusion-associated bacterial infection is a major risk of platelet transfusion and can be fatal. The storage requirements of platelet concentrates…

Making Rituximab Directly Cytotoxic for Substantial Improvement in Therapeutic Efficacy

The humanised anti-CD20 antibody (Ab) rituximab (RTX) has significantly improved the prognosis of B cell non-Hodgkin’s lymphomas (BNHL). However, major…

Lenalidomide: The Gift That Keeps on Giving

First-line therapy for indolent non-Hodgkin’s lymphoma usually consists of a combination of rituximab-based chemoimmunotherapy. Historically, first-line…

Staging of Mycosis Fungoides and Sézary Syndrome: Time for an Update?

Mycosis fungoides is the most common variant of cutaneous T cell lymphoma and frequently presents as early-stage disease with skin patches and plaques with an indolent course, but patients experience significant morbidity from itch and disfigurement.

A Targeted Next-Generation Sequencing-Based Diagnosis for Hereditary Anaemias

Anaemia affects 1.6 billion people worldwide, with roughly 10% of these individuals affected by rare anaemias, of which 80% are hereditary. Hereditary…

Iron Deficiency Anaemia in Pregnancy: Developed Versus Developing Countries

Anaemia is the most widespread of the haematological disorders, affecting about one-third of the global population. Despite decades of public health…

Genes and Pathways Dysregulated by Nilotinib Treatment in Bone Marrow CD34+/Lin- Cells of Patients with Chronic-Phase Chronic Myeloid Leukaemia

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disorder with heterogeneous biological and clinical features. Specifically, it presents a…