Platelet-Rich Plasma Injections Improve Hair Density
Autologous platelet-rich plasma (PRP) injections were shown to safely enhance hair density and thickness in patients with androgenetic alopecia, according to a prospective clinical study.
Study Design and Methodology
Researchers evaluated five patients with moderate to severe hair loss who received three PRP injections at four-week intervals. The PRP was prepared using the double-spin method from each patient’s own blood and injected into the scalp. Clinical assessment included the pull test, macroscopic imaging, biopsy analysis, and patient-reported satisfaction surveys conducted at baseline, three weeks, six weeks, and three months.
Key Findings
By the third injection, participants demonstrated measurable improvements in follicle density and reduced hair shedding. Mean follicle density increased to 38.6 ± 7.6 at three months, accompanied by notable gains in hair thickness. Patient satisfaction also rose, with average self-reported scores of 8.2 after ten weeks. No major adverse effects were observed, underscoring the treatment’s favorable safety profile.
Clinical Implications for Hair Loss Treatment
The findings highlight PRP therapy as a promising, minimally invasive treatment for androgenetic alopecia in both men and women. By leveraging the regenerative potential of platelets to stimulate follicular growth, PRP may offer an effective alternative for patients seeking nonsurgical hair restoration options. Further large-scale studies are warranted to confirm long-term outcomes and optimal treatment protocols.
These findings reinforce growing clinical interest in autologous platelet-rich plasma therapy as a regenerative dermatologic intervention. By concentrating growth factors that activate follicular stem cells, PRP may support long-term scalp health and sustained regrowth. Its favorable safety profile and patient-reported satisfaction suggest potential integration into multimodal management approaches for androgenetic alopecia alongside topical or pharmacologic treatments.
Reference: Khan AM et al. Evaluation of Role and Efficacy of Autologous Platelet-Rich Plasma Injection Treatment for Hair Loss: A Prospective Clinical Trial. J Pharm Bioallied Sci. 2025;17(Suppl 3):S2381-S2383.
