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Novel Cholesterol Drug Outperforms Existing Treatments

Novel Cholesterol Drug Outperforms Existing Treatments

April 2026

The oral PCSK9 inhibitor achieved a mean LDL-C reduction of -64.6% from baseline, substantially outperforming bempedoic acid (-6.3%), ezetimibe (-27.8%), and combination therapy (-36.5%).

Nonviral Gene Therapy Shows Promise for Age-Related Heart Disease

Nonviral gene therapy to boost brown fat molecule reverses age-related heart dysfunction in animal studies.

Aspirin Not Recommended for Primary Prevention in Older Adults

Study finds no long-term cardiovascular benefit from aspirin in healthy older people, but highlights increased bleeding risk.

Long COVID: Cardiovascular Patterns Revealed with Smartwatch Biometrics

Wearables reveal unique activity and heart rate patterns in long COVID, showing promise as clinical biomarkers.

Semaglutide Lowers Cardiovascular Risks But Raises Health Care Costs

Semaglutide improves cardiovascular risk factors but raises health care costs, finds large multicentre cohort study.

CPAP Reduces Cardiovascular Risk in High Risk Obstructive Sleep Apnoea

CPAP therapy lowers cardiovascular risks in high-risk obstructive sleep apnoea patients, new multi-trial study finds.

Pregabalin Raises Heart Failure Risk More Than Gabapentin in Older Adults

Discover the higher risk of heart failure with pregabalin versus gabapentin in older adults. Read the full study findings.

Does Early Cardiac Rehabilitation Improve Severe Acute Heart Failure?

Early cardiac rehabilitation did not improve function or rehospitalisation in severe heart failure, but mobility gains were seen.

Physical Activity Drops Years Before Heart Disease Diagnosis, Study Finds

Adults later diagnosed with cardiovascular disease show declining activity years before onset, highlighting the importance of lifelong exercise.

Obesity Severity and Tirzepatide’s Impact on Heart Failure Outcomes: New Insights

Tirzepatide improves outcomes in heart failure with obesity, with greatest physical benefits seen in those with higher BMI.

Heart Disease Mortality Falls as Other Cardiac Deaths Climb in US Study

US heart deaths have dropped since 1970, but deaths from heart failure and arrhythmias are on the rise.

Impact of LMNA Variant Location on Cardiac Outcomes in Cardiomyopathy

Discover how LMNA gene variant type and position impact cardiomyopathy risk—keep reading for clinical implications and treatment guidance.

How Does a Late Hypertension Diagnosis Impact Cardiovascular Outcomes?

Delayed hypertension diagnosis increases cardiovascular risk and lowers treatment rates, underscoring the value of prompt clinical action.

Night-Time Blood Pressure Better Controlled with Bedtime Dosing in Hypertension

Discover how bedtime antihypertensive dosing benefits blood pressure control. Keep reading for clinical insights and recommendations.

AI Outperforms Traditional Cardiac Amyloidosis Detection with a Single Echocardiogram

AI screening from a single echocardiographic clip accurately detects cardiac amyloidosis, surpassing traditional diagnostic methods.

New AI Model Improves Sudden Cardiac Death Prediction

MAARS uniquely integrates electronic health records, imaging reports, and contrast-enhanced cardiac MRI using a transformer-based neural network.

GLP-1s Reduce Heart Failure and Kidney Complications in Monoclonal Gammopathy and Type 2 Diabetes

GLP-1 receptor agonists cut heart, stroke, and kidney risks in people with MGUS and diabetes, new study finds.

Paediatric Cardiac Arrest: Epinephrine Route Choice Does Not Impact Survival

Find out how epinephrine administration routes impact survival in paediatric cardiac arrest—explore the latest evidence now.

AI Achieves High Accuracy in Automated Echocardiogram Interpretation

AI now matches experts in echocardiogram interpretation, promising faster, more accessible heart diagnostics for all patients.

New Evidence Supports Finerenone Use in Heart Failure, Regardless of Frailty

Finerenone benefits heart failure patients with preserved ejection fraction, regardless of frailty, supporting its wider clinical use.

Edoxaban Suitable for Stroke Prevention in Over-75s with AF?

Edoxaban and rivaroxaban show best balance of efficacy and safety in elderly patients with atrial fibrillation.

Two Decades On, Atrial Fibrillation Outcomes Show Uneven Progress

Patients with atrial fibrillation now live longer after stroke, heart failure, or myocardial infarction, but bleeding risks remain unchanged.

Loneliness is Linked to Higher Heart Disease Risk Across Cultures

Loneliness increases heart disease risk by 15% in both US and South Korea, major study finds.

Beta-Blocker Discontinuation After Myocardial Infarction Linked to Increased Risks

Beta-blocker interruption after heart attack raises blood pressure and heart rate, increasing risks especially in hypertensive patients.

Does Timing of Antihypertensives Affect Their Effects?

Timing doesn’t matter! Study finds no added heart benefit from bedtime blood pressure meds.

DASH Diet Reduces Hypertension and Colorectal Cancer Risk

Understand how the DASH diet significantly lowers the risk of colorectal cancer, supporting dietary changes for cancer prevention.

Can Yoga Decrease Hypertension Risk?

Discover how yoga may reduce blood pressure, but further investigation is needed to validate these results.

SGLT2 Inhibitors Reduce Hyperkalaemia Risk in RAASi Use

SGLT2 inhibitors reduce hyperkalemia risk, aiding RAASi continuity in high-risk patients.

Shingles Vaccine Tied to Lower Cardiovascular Risk

A new study has revealed a potential link between live zoster vaccination and a reduced risk of cardiovascular disease.

New Risk Model Predicts Hyperkalaemia in Chronic Kidney Disease and Type 2 Diabetes

New risk model predicts hyperkalaemia in CKD and diabetes, enabling tailored care and safer treatment decisions for patients.

Global Registry Study Reveals Pregnancy Complications with Mechanical Heart Valves

Pregnancies with mechanical heart valves carry high risks, as a global registry reveals stark outcomes.

Blood Pressure Variability: A New Focus for Preventing Heart and Kidney Disease

Rising systolic blood pressure variability increases risks of heart disease, kidney disease, and death.

Intensive Blood Pressure Control Cuts Dementia Risk by 15%

Blood pressure control over 48 months cuts dementia risk by 15% in a large clinical trial.

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