Flagship Journal

Chronic kidney disease (CKD) is a significant public health concern that leads to higher mortality, increased illness, and reduced quality…

Non-cystic fibrosis bronchiectasis (NCFB) is a heterogeneous disease characterised by a ‘vicious vortex’ of pathophysiological processes…

Becker is a serious, progressive neuromuscular condition that is X-linked, affecting approximately one in 18,000 male births.1,2 It is…

When the COVID-19 pandemic reached Europe, little was known. It was mostly reported by the Chinese authorities, and therefore…

Periorbital necrotising fasciitis (PNF) or streptococcal gangrene is a rare infection that affects the periorbital region, the surrounding…

Two mutated alleles of the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in the autosomal recessive hereditary…

One thing that we’re seeing is lung cancers being diagnosed earlier and earlier, whereas, historically, 75% of lung cancers were diagnosed at…

The Science of Staying Healthy: Interview with Michael Snyder. Director, Center for Genomics and Personalized Medicine, Stanford…

BK is a short-lived effector molecule that belongs to the peptide family of kinins and plays a crucial role in inflammation. It was first…

Spacers or valved holding chambers added to pressurised metered dose inhalers (pMDI) reduce errors in inhaler technique and improve…

We are entering an era of precision healthcare, where genomics and other -omic tests, which are measures of your RNA, proteins…

Acne vulgaris, commonly known as acne, is a skin disease caused by the blockage of hair follicles, high keratin and sebum production in…

Prostate cancer remains one of the most prevalent malignancies among men worldwide, underscoring the need for effective diagnostic…

Psoriasis affects 60 million people globally. It is an inflammatory skin condition that can significantly impact quality of life…

Leiomyosarcoma (LMS) is a malignant neoplasm characterised by smooth muscle differentiation. It is the second most common sarcoma to…

Up to a quarter of patients with classical Hodgkin’s lymphoma (HL) are resistant or have disease relapse after first-line chemotherapy…

Sepsis continues to be a significant contributor to maternal mortality, and is responsible for approximately 11% of maternal deaths…

You initially trained as a doctor, specialising in adult medicine, before transitioning to clinical genetics…

Now, for those who don’t know, 10–15% of babies go into the NICU when they’re born, and sometimes it’s because the baby was born…

Learn more about the long-term health effects persisting one year after COVID-19 infection, including fatigue, breathlessness…

At this EAACI 2025 symposium, experts discuss CRSwNP and Severe Asthma, the associated patient burden, and explore the role of IL-5…

Urological cancers are malignancies that affect the organs of the urinary system and male reproductive system. Of these, bladder cancer…

Acne is a chronic inflammatory skin disease whose visible effects can have a significant psychological impact on patients. A multimodal…

Inhalation therapy is central to the treatment of patients with COPD, a condition that affects an estimated 480 million people;…

In the context of increasing healthcare complexity and chronic disease prevalence, patient engagement is gaining recognition as a key…

Kidney stones are the most common condition affecting the urinary system, impacting approximately 8–12% of the global population…

Diabetes is a chronic metabolic disorder characterised by persistently high blood sugar levels (hyperglycaemia) caused by deficiencies…

Cases involving co-infections with Mycoplasma pneumoniae and varicella-zoster virus (VZV) are exceedingly rare in medical literature…

The Actinomyces family includes 47 different species. Actinomycosis infections are characterised by abscess formation, granulation…

Lifestyle medicine is a large topic area to cover, but there have been some notable advancements in the areas in which I work that are…

Infective endocarditis (IE) often presents in an unusual and vague manner, especially in its early stages, where symptoms can be…

I’m a clinical academic, which is quite a rare breed of doctor, because what I’m doing, along with other clinical academics, is being…

Both my parents were in the preventive health field; both were integrated providers, chiropractors, and acupuncturists. My dad has a…

David Katz | Chief Medical Officer, Tangelo, Intend; Founder/CEO, DietID, Detroit, Michigan, USA. What initially sparked your interest in…

This article summarises an Orchard Therapeutic-sponsored symposium titled ‘New horizons for metachromatic leukodystrophy – with the advent…

Altered gut microbiome profiles correlate with anxiety and depression in humans, and work in animal models has identified specific…

The human body is a holistic system, interconnected by the circulatory, nervous, lymphatic, endocrine, and immune systems that facilitate…

The upper gastrointestinal microbiome, a complex ecosystem of microorganisms that have historically been difficult to identify, may play a…

Multifocal motor neuropathy (MMN) is a rare immune-mediated disorder characterised by progressive, asymmetric muscle weakness…

An acute necrotising myopathy is a distinct form of uncommon muscle disease characterised by the rapid advancement of weakness affecting…

Peritoneal tuberculosis (TB) is a form of extrapulmonary TB that primarily affects areas such as the omentum, liver…

A recent randomised controlled trial came to the surprising conclusion that dual gonococcal treatment with azithromycin/ceftriaxone…

Following an admission to the authors’ centre with severe anaemia, duodenal biopsy confirmed the diagnosis of Whipple’s disease…

This article has now been retracted and a retraction statement has been published.

It takes an interdisciplinary approach to solve complex problems in the microbiome because you couldn’t ask for a more complex system.

Our key discoveries range from epidemiologic evidence on breastfeeding and chronic disease prevention to mechanistic research on breast milk compounds and the infant microbiome.

Preterm premature rupture of the membranes (PPROM) impacts 5–7% of all pregnancies. A pregnancy is considered previable, the fetus having…

This article summarises a LivaNova-sponsored symposium entitled ‘The Power of Real-World Evidence with CORE-VNS’, delivered on 7th…

IgA nephropathy (IgAN) can impact life expectancy in those affected, thus efficacious treatment is key. Endothelin 1 (ET-1) and angiotensin…

Fertility rates have reached the lowest level in recent years all over the world, even in traditionally overpopulated nations such as…

The editor’s pick for this issue is a review article discussing the promise of hyperpolarised xenon MRI, a non-invasive imaging technique…

Type 2 inflammation is involved in severe asthma (SA), chronic rhinosinusitis with nasal polyps (CRSwNP), and eosinophilic granulomatosis…

Endometriosis is defined as the presence of endometrial glands and stroma outside the uterine cavity, which commonly presents with…

Tuberculosis (TB) represents a significant global public health issue, ranking as the 13th leading cause of mortality and standing as the…

Radiographic axial spondyloarthritis (r-axSpA), formerly known as ankylosing spondylitis (AS), is a chronic inflammatory disease that…

Human papillomavirus (HPV) is a sexually transmitted infection linked to genital, anal, and oral warts, as well as cervical and other…

Tuberculosis (TB) is caused by the bacteria Mycobacterium tuberculosis, a complex, rod-shaped, non-spore-forming, thin, aerobic bacterium…

The uncus is a hook-shaped structure located on the most anteromedial aspect of the parahippocampal gyrus, which is part of the medial…

Leiomyomas or fibroids are the most frequently encountered benign neoplasm of smooth muscle origin in women of reproductive age…

Non-steroidal anti-inflammatory drugs (NSAID) are useful in treating musculoskeletal disorders, headaches, pain, fever, and others…

Looking back to the year 2000, we were very divided across the world in understanding PCOS. The Americans had a different definition from…

Advances in Therapy to Address Proteinuria in Patients with Immunoglobulin A Nephropathy. As the majority of patients with IgA…

At the 2024 European Association of Neurology (EAN) Congress, one satellite symposium discussed the recognition, diagnosis, and treatment…

Hyperpigmentation disorders, a group of common skin conditions characterised by darkened patches due to excess melanin production, affect…

Osteoarthritis (OA) is the most common arthritis worldwide, causing pain, disability, and loss of function due to chronic joint disease​​…

Gadolinium is an invaluable contrast agent in MRI that has various important benefits in radiology. Its unique magnetic properties allow…

COVID-19 is a novel β-coronavirus caused by infection with SARS-CoV-2. It is the third zoonotic disease caused by coronavirus to affect…

The worldwide prevalence of benign prostatic hyperplasia (BPH) varies between 20–60% in men over 50 years. Similarly, about 50% of men…

A brain tumour develops as a result of abnormal cell growth in the brain. Tumours are classified as malignant or benign. Malignant tumours…

Obstructive sleep apnoea (OSA) is a complex and chronic disease characterised by loud snoring, daytime sleepiness, and witnessed breathing…

Gynaecomastia, the clinical term for the enlargement of the male breast, is characterised by the histological finding of…

Tuberculosis is a well-known endemic disease in India; however, extra-pulmonary tuberculosis in the form of single parotid gland…

Vasculogenic female sexual dysfunction syndromes affect millions of ageing women worldwide, whose day-to-day symptoms of coital…

This study investigates the impact of extracapillary proliferation in proliferative lupus nephritis on remission rates in patients.

This article reviews real-world data presented at the ADA Scientific Sessions 2024. It demonstrates the glycaemic range when Control-IQ Technology users do not manually bolus for extended periods

I have worked previously in healthcare management consulting, health services research, clinical practice, and healthcare administration…

For clinical applications of AI, it’s still early; most are unlikely to be found at the patient’s bedside and are still in the research…

The rare diseases Duchenne and Becker are X-linked recessive neuromuscular disorders.1 They are characterised by progressive…

Climate change is happening, with the evidence clearly demonstrating an increase in global temperatures; extreme weather events…

Nebulisers are devices used to rapidly deliver high doses of medication to the lungs in people with respiratory disease…

One in 10 people may be affected by a rare disease (RD) in their lifetime.1 This is the surprising paradox of RDs. While each disease…

Children diagnosed with congenital heart disease (CHD) have an increased risk of developing neurodevelopmental disabilities…

Zinc salts are one of three approved treatments for the autosomal recessive condition Wilson’s disease (WD). Their use was first described…

A previously healthy 17-year-old male was transferred from a community hospital to the authors’ tertiary paediatric emergency department…

Dermatitis artefacta (DA), also known as artefactual skin disease, is a rare psychocutaneous disorder characterised by…

Nipah virus disease is a zoonotic infection caused by the Nipah virus (NiV) of the Genus Henipavirus of the Paramyxoviridae family…

Erection is a neurovascular response accompanied by the release of neurotransmitters. The penis is innervated by autonomic (sympathetic…

Infection leads to an increased rate and duration of hospitalisation, increased treatment costs, and high morbidity and mortality in…

Severe cutaneous adverse drug reactions (SCAR) are a group of rare but potentially life-threatening conditions that can occur in response…

Superior vena cava syndrome (SVCS) is a group of clinical manifestations, caused by an obstruction of venous blood flow to the heart…

Dr Enrique Casado and Professor Lothar Seefried talk about the of early identification of individuals at risk of osteoporosis fractures…

Maternal and fetal outcomes associated with the authors’ approach of Caesarean hysterectomy for placenta accreta spectrum disorders…

I always knew that I wanted to work with children. My mother is a paediatric nurse practitioner, and my father is a child psychiatrist…

In patients with immunoglobulin A nephropathy, use of the endothelin 1 Type A/Ang II subtype 1 receptor antagonist sparsentan can decrease proteinuria and preserve kidney function

Targetted prophylaxis is recommended for people with HAE, but many remain on attenuated androgens. EMJ spoke to two HAE experts who explain how they help patients to make the switch.

Emer Kelly. Respiratory Consultant and General Physician, St. Vincent’s University Hospital, Dublin, Ireland. I had asthma as a child, so…

Kiley Whalen. Physician Assistant, Adirondack Rehabilitation Medicine; Master of Science in Physician Assistant Studies at the Center for…

Methotrexate (MTX), an antimetabolite, has a multifarious mechanism of action that most notably includes folate antagonism, effects on…

Cervical cancer is established as a major cause of morbidity and mortality among females globally.1 In Kenya, and other countries with…

End-stage liver disease (ESLD) represents a non-reversible, advanced stage of cirrhosis, where the hepatic architecture is distorted and…

Endoscopic retrograde cholangiopancreatography (ERCP) includes specialised techniques, such as sphincterotomy, balloon dilation…

Smeeta Sinha National Clinical Director for Renal Medicine, NHS England, UK; Consultant Nephrologist, Northern Care Alliance NHS Foundation…

After being diagnosed with cancer, patients embark on a journey that involves ongoing treatments, and regular visits to healthcare…

Patients with chronic kidney disease (CKD), especially those on chronic haemodialysis (HD), have a higher incidence of nosocomial…

Multiple myeloma (MM) is a disease characterised by the clonal expansion of malignant plasma cells in the marrow, leading to anaemia…

Sickle cell disease (SCD) is a genetic condition caused by mutations in the haemoglobin (Hb) gene, resulting in various complications. One…

HIV is an epidemic in Kenya. Females living with HIV (FLHIV) have an eight-fold increased risk of a pregnancy-related death compared to…

I am interested in family medicine and primary healthcare because primary healthcare is the first gatekeeper in the community…

Mycobacterium tuberculosis causing glomerulonephritis (GN) is a rare occurrence, and its association has been seldom reported…

IgAN, which can lead to CKD and kidney failure, is the most common form of primary glomerulonephritis, predominantly…

Many patients experience impairment following a stroke, including motor or cognitive impairment, urinary incontinence, dysphagia…

First described by German physician Peter Emil Becker in the 1950s, Becker is an X-linked genetic recessive disorder. Like Duchenne…