Gastroenterology

In this latest study, researchers showed that while the ketogenic diet maintained intestinal balance under normal conditions, it significantly exacerbated colitis when the gut lining was damaged.

Automated text messages significantly improve colorectal cancer screening uptake compared to phone calls, offering a scalable, low-cost strategy.

Early infliximab use in acute severe ulcerative colitis reduces hospital stay without increasing complications, new study shows.

Urban residency is associated with more severe allergic features and inflammation in eosinophilic esophagitis, new research shows.

New research reveals a lack of consensus in defining moderate Crohn’s disease and ulcerative colitis, limiting optimal treatment decisions.

A large multicentre study finds GLP-1 receptor agonists do not increase pancreatitis risk and are associated with fewer complications and lower mortality in Type 2 diabetes.

New research reveals impaired fibre metabolism in celiac disease. Fibre supplementation may support gut microbiota and enhance gut healing.

CXCL12, a chemokine involved in immune cell trafficking and tumour microenvironment regulation, appeared to be strongly associated with improved survival outcomes.

Scientists have unveiled a novel injectable acid-tolerant bioadhesive for large gastric perforation.

New nomogram integrates clinical and endoscopic features to distinguish high-risk colorectal lesions from hyperplastic polyps.

This study establishes an increase in both incidence and extensiveness of newly diagnosed inflammatory bowel disease in paediatric patients over the last 40 years, and points to the necessity of further research regarding long-term outcomes.

Pre-pregnancy parental obesity is linked to nearly four times higher odds of liver disease in offspring, a 2026 cohort study has found.

Deep learning models have matched the diagnostic accuracy of expert endoscopists in detecting early gastric cancer.

Colorectal cancer is now the leading cause of cancer death in men and women in the USA under the age of 50 combined, a new study by the American Cancer Society has revealed.

A review of 22 trials finds intermittent fasting offers little to no additional weight loss benefit compared with regular dietary advice in adults with overweight or obesity.

A nationwide cohort study shows people with intellectual disabilities are less likely to participate in colorectal cancer screening and complete follow-up colonoscopy.

Cranberry extract supports intestinal barrier function by promoting mucin secretion, antimicrobial activity, and microbiota-driven epithelial reinforcement.

Fecal metabolites interact with gut microbes in Crohn’s disease, revealing signals that could guide new treatments and dietary strategies.

The UK Health Security Agency has issued a Cape Verde health warning following an increase in cases of gastrointestinal infections among travellers.

New research shows supervised machine learning models combining Helicobacter pylori genomic data with patient demographics can accurately predict gastric cancer risk.

Current drinkers with an average lifetime alcohol intake of 14 or more drinks per week had a 25% higher risk of colorectal cancer.

A cross-sectional study shows resilience mediates the relationship between cognitive flexibility and psychological well-being in irritable bowel syndrome, identifying potential targets for psychological intervention.

New real-world data suggest early lactate clearance can predict massive transfusion needs in upper gastrointestinal bleeding, improving early risk stratification when combined with the Glasgow-Blatchford score.

A large network meta-analysis finds dual therapy for Helicobacter pylori offers comparable eradication rates with fewer side effects and better compliance than triple or quadruple regimens.

Real-world data show how microbiological findings and patient factors can guide empirical antibiotic choice in acute cholangitis, supporting carbapenem-sparing strategies in selected patients.

Real-world data show distinct determinants of health-related quality of life in Crohn’s disease and ulcerative colitis, highlighting phenotype-specific roles of inflammation, imaging findings, treatment burden, and modifiable risk factors.

A decade-long retrospective study shows IgG4-related cholangitis responds well to steroids, with low mortality and no progression to cholangiocarcinoma.

Integrated structural and functional MRI identifies brain-based biomarkers that distinguish active from remissive Crohn’s disease and correlate with gut inflammation.

New research shows resilience partially offsets financial toxicity and improves quality of life in patients with primary liver cancer, highlighting the importance of psychosocial support.

Colonic stent placement as a bridge to surgery shows similar survival to emergency resection while reducing stoma rates in obstructive colorectal cancer.

A randomized trial shows combined water exchange and cap-assisted colonoscopy shortens cecal intubation time and reduces pain in unsedated procedures.

A retrospective cohort study shows that gastrointestinal involvement in granulomatosis with polyangiitis is linked to higher disease activity, earlier relapse, and a threefold increase in mortality risk.

CT imaging features including appendicolith, appendiceal diameter, fat stranding, and periappendiceal air help identify patients at risk of complicated acute appendicitis.

A hybrid AI-human scoring system delivers expert-level accuracy in ulcerative colitis endoscopic assessment while reducing human review by 81 percent.

Early-stage primary biliary cholangitis shows distinct blood lipid changes tied to inflammation and fibrosis, offering clues to disease activity and potential new biomarkers.

A new longitudinal study finds that many adolescents with IBS struggle to manage complex treatment plans, highlighting key barriers to effective self-management.

Global research finds that gut microbiota dysbiosis strongly correlates with rising inflammatory bowel disease rates worldwide.

Chronic hepatitis C infection has been linked to a higher risk of pancreatic cancer.

New research reveals that bone broth’s amino acids and minerals can fortify the gut barrier and ease inflammation, providing scientific backing to its traditional use in digestive health.

A new study finds that sleeping with a low pillow height significantly increases the risk of throat reflux in patients with GERD, suggesting that simple lifestyle changes like elevating the head during sleep may ease symptoms.

Antithrombotic therapy does not affect polyp, adenoma, or cancer detection in FIT-positive colonoscopies after adjusting for age and sex.

A large-scale Korean study of over 115,000 adults has found that eating one to three servings of kimchi per day is linked to a lower risk of obesity and abdominal fat.

A new study finds that a staged health education pathway checklist improves discharge readiness and health literacy in esophageal cancer surgery patients.

A study of over 3,800 ICU patients finds the lactate-to-glucose ratio predicts short-term mortality in cirrhosis, offering a simple new tool for bedside risk assessment.

A Japanese multicentre study finds linked colour imaging significantly reduces missed colorectal polyps compared with standard white light imaging, improving adenoma detection rates.

A UK Biobank study finds aspirin users with multiple cardiometabolic risk factors—such as diabetes and hypertension—have nearly double the risk of GI bleeding.

A randomised trial shows 200 mg simethicone with PEG-ELS is as effective as 1200 mg for bowel cleansing and adenoma detection in afternoon colonoscopy.

A nationwide Icelandic study confirms an ICD-10 algorithm accurately identifies major GI bleeding in anticoagulated patients, improving reliability of registry-based research.

New ESSENCE trial data show semaglutide improves liver histology and non-invasive markers in MASH through mechanisms beyond weight loss, highlighting dual metabolic benefits.

New joint statement from United European Gastroenterology and the German Society for Gastroenterology calls for coordinated prevention, early detection, and policy reform to reverse the rising tide of liver cancer across Europe.

Discover a new study showing both sugary and artificially sweetened drinks raise the risk of liver disease, with water emerging as the healthiest choice.

Discover a study showing how microplastics alter the gut microbiome, with changes linked to digestion, depression, and colorectal cancer risk.

A real-world study finds upadacitinib induces remission and mucosal healing in biologic-refractory Crohn’s disease patients, confirming its effectiveness and safety.

A large UK Biobank study has found that exposure to hard water is associated with reduced prevalence of Crohn’s disease and ulcerative colitis.

Discover a study revealing how insomnia raises the risk of GERD and IBS, with genetic evidence linking poor sleep to gastrointestinal health.

A UK Biobank study finds abdominal fat significantly raises GERD risk, with stronger associations in women than men.

A study from Cairo University Hospital reveals that gastric scintigraphy and the Gastroparesis Cardinal Symptom Index are valuable tools for diagnosing diabetic gastroparesis and predicting treatment outcomes.

Mesenteric fat proliferation on MRI scans is linked to higher risks of hospitalization and surgery in Crohn’s disease, suggesting a new imaging marker for long-term outcomes.

A study of over 235,000 colonoscopies found that people aged 45–49 had similar polyp and carcinoma detection rates as those aged 50–54, supporting earlier colorectal cancer screening.

Learn how GLP-1 RAs may cut peptic ulcer risk in diabetes patients by nearly half.

Uncovered self-expanding metal stents (SEMS) and balloon dilation are safe and effective treatments for benign gastric outlet obstruction; however, SEMS should not be the first choice due to its associated cost and complications.

People with gastrointestinal disorders face a higher risk of sleep problems, including insomnia and shorter sleep duration, according to a large U.S. study.

A new study finds that PD-1 inhibitors combined with chemotherapy achieved a 97.7% disease control rate and median progression-free survival of 13.5 months in advanced gastric cancer patients.

A study finds that elevated trimethylamine N-oxide (TMAO) levels are linked to increased risk of abdominal aortic aneurysm development, faster aneurysm growth, and higher likelihood of surgical intervention.

A study of nearly 300 women with obstructive defecation syndrome found that combining transperineal ultrasound with anorectal manometry offers a clearer picture of pelvic floor structure and function.

A large safety analysis of infliximab and adalimumab in pediatric inflammatory bowel disease highlights the need for continued postmarketing monitoring, with new concerns emerging for long-term infliximab use.

A Vietnamese retrospective study challenges the push for endoscopy within 12 hours in patients with esophageal variceal bleeding.

A new study demonstrates that fecal calprotectin levels, measured using fluorescent immunochromatography assay (FICA), strongly correlate with disease activity in ulcerative colitis, offering non-invasive thresholds to better guide patient care.

New research suggests that PRO-C16, a blood-based marker of type XVI collagen formation, may help detect intestinal fibrosis in patients with Crohn’s disease.

A large Iranian study has found no significant association between gastroesophageal reflux disease (GERD) and higher tooth decay rates.

New research reveals that a high-fat diet can boost levels of the gut bacterium Bacteroides thetaiotaomicron, which in turn produces palmitic acid—a fatty acid that enhances blood clotting and cardiovascular risk.

A study of AI-guided infection prevention in hospitals found no drop in C. difficile rates but did see reduced use of risky antibiotics, especially in high-risk patients.

New data from China shows vedolizumab delivers comparable long-term outcomes and safety in elderly and younger patients with moderate-to-severe ulcerative colitis.

New research shows IBS patients suffer higher depression and worse sexual health compared to healthy individuals, highlighting the condition’s broad impact on wellbeing.

A new in vitro study reveals sex-specific differences in the digestion of milk and oat-based drinks, offering important insights for personalized nutrition and food innovation.

Patients with functional anorectal pain show abnormal anal pressures, rectal hypersensitivity, and high rates of anxiety and depression, new study reveals.

A new study highlights the clinical promise of AI-driven IHC prediction models, showing high accuracy and diagnostic concordance with conventional pathology.

A new study found that the timing of small-bowel capsule endoscopy does not significantly affect detection rates of bleeding sources.

A prospective study has found that the Mediterranean diet may help reduce inflammation and support a healthier gut microbiome in newly diagnosed Crohn’s disease patients.

In patients with achalasia, esophageal Candida infection may be more than an incidental finding. A new study reveals it significantly increases the risk of developing esophageal cancer.

A large randomized clinical trial suggests that adults with uncomplicated appendicitis can safely wait for surgery without receiving antibiotics.

A study has found that H. pylori infection in gastric cancer is linked to reduced tumour-infiltrating lymphocytes and poorer patient outcomes.

Combining gelatin sponge with NBCA glue proved most effective in stopping arterial gastrointestinal bleeding, significantly outperforming sponge alone or with microcoils.

A Vietnamese study finds that a new mean nocturnal baseline impedance threshold of 1500 Ohms improves diagnostic precision for acid reflux disease.

Read about how mirikizumab shows strong results for IBD, improving remission and response rates.

Results from the phase 3 QUASAR trials show that guselkumab offers effective and safe induction and maintenance therapy for moderate-to-severe ulcerative colitis, with nearly 50% of patients achieving clinical remission after one year.

Pregnant individuals with IBD prescribed low-dose aspirin were no more likely to experience flares than those not on aspirin, according to a new study, easing concerns about its use in this high-risk population.

A new analysis from nearly 20,000 participants in the U.S. NHANES study has identified the platelet-to-high-density lipoprotein ratio (PHR) as a strong predictor of gastrointestinal cancer risk.

Tirzepatide linked to more GI issues than semaglutide in new study on weight-loss drugs without diabetes. Read more!

While both bariatric surgeries aid weight loss and quality of life, Roux-en-Y gastric bypass shows greater benefits for reducing acid reflux and oesophageal inflammation.

Research shows that compounds produced during cabbage fermentation protect gut lining from cytokine damage, highlighting the potential of fermented foods in gut health.

A new umbrella meta-analysis finds strong evidence that probiotics, particularly multi-strain formulations, reduce the risk of necrotising enterocolitis (NEC) and death in preterm babies.

New data from Ontario reveals a concerning rise in alcohol-related gastrointestinal diseases among people aged 13 to 39, with young women showing the steepest increase.

Researchers report that a novel cap-assisted clip closure technique shortens procedure time without compromising safety in patients undergoing endoscopic tumour resection.

New research suggests matcha may offer greater protection than green tea against intestinal injury caused by gamma radiation, via the TAK1–TAB pathway.

A new study links high glycemic index and load diets with increased risk of pancreatic steatosis, while fibre intake appears protective.

A new mobile app is helping doctors adhere to colorectal cancer screening guidelines, reducing unnecessary colonoscopies while identifying high-risk patients needing intensive follow-up.

A large international study shows that intestinal ultrasound during pregnancy can reveal hidden inflammatory bowel disease activity, significantly improving prediction of complications like preterm birth and preeclampsia, beyond what clinical symptoms and lab tests can detect.

New findings from a decades-long study of over 470,000 adults show that higher calcium intake may significantly reduce the risk of colorectal cancer, regardless of whether it comes from dairy, non-dairy foods, or supplements.

A novel minimally invasive endoscopic technique has proven safe and effective in removing gastric fundal subepithelial lesions, including low-risk GISTs, according to a recent study.

A novel IgG-guided elimination diet shows potential in reducing abdominal pain in patients with irritable bowel syndrome.

A new study found that children with COVID-19 have a 25% higher risk of developing persistent gastrointestinal symptoms months after infection.

Despite the significant health burden, there are gaps in managing alcohol-related digestive diseases.

A new blood test, PAC-MANN-1, could dramatically improve early detection of pancreatic cancer, one of the deadliest malignancies.