Gastroenterology

A prospective study found subclinical pulmonary dysfunction in patients with IBD, with small airway indices detecting changes despite absent respiratory symptoms.

A compact colon-specific epigenetic clock accurately predicted age and revealed accelerated ageing associated with HIV infection, IBD, and colonic polyps.

Leukocyte telomere length showed limited diagnostic and prognostic value in pancreatic ductal adenocarcinoma, while exploratory microbiome data found no significant group differences.

A systematic review identified primary sclerosing cholangitis and preoperative steroid use as the most reliable risk factors for pouchitis after IPAA.

A 10-year study found that terminal ileitis detected by computed tomography led to a Crohn’s disease diagnosis in only 12.5% of patients.

New data showed that Crohn’s disease monocytes were systemically reprogrammed before intestinal recruitment, with transcriptional and functional changes linked to inflammatory activity.

BAASNet improved polyp segmentation across nine datasets and five imaging modalities, demonstrating gains in Dice performance and potential for real time automated colonoscopy workflows.

Antimicrobial resistance and Enterococcus infections were associated with delayed resolution, more interventions and poorer outcomes after pancreatic fluid collection therapy.