Respiratory

In a new multicenter trial, navigational bronchoscopy was found to be noninferior in diagnostic accuracy to transthoracic needle biopsy (TTNB) for evaluating peripheral pulmonary nodules, while significantly reducing the risk of procedural complications such as pneumothorax.

A large randomized trial has found that as-needed use of a fixed-dose combination of albuterol and budesonide significantly reduces the risk of severe asthma exacerbations compared to albuterol alone in patients with mild asthma.

Adults hospitalized with respiratory syncytial virus (RSV) face a significantly greater risk of acute cardiovascular events compared to those admitted for COVID-19 or influenza, according to new findings from a population-based study.

Long-term exposure to urban environmental factors, particularly air pollution, lack of green space, and dense built environments, significantly increases the risk of developing asthma across the life course, according to a large-scale analysis involving 14 European cohorts and more than 340,000 participants.

Children with complex chronic diseases (C-CDs) and life-limiting conditions (LLCs) account for a disproportionate share of pediatric hospital admissions and resource use, according to a new retrospective study conducted in the Basque Public Health System.

Air pollution significantly increases inflammatory markers in outdoor athletes, particularly those with allergies, according to new research examining the immune effects of PM2.5 exposure during exercise.

THE U.S. Food and Drug Administration has approved a novel inhaled formulation of treprostinil for adults with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with interstitial lung disease (PH-ILD), adding a new option for improving exercise ability in these patient populations.

In a Phase III clinical trial, nerandomilast, an oral phosphodiesterase 4B inhibitor, was associated with a smaller decline in lung function over 52 weeks in patients with progressive pulmonary fibrosis, when compared with placebo.