Respiratory

A first-in-human trial has demonstrated encouraging clinical activity and manageable safety for the DLL3-targeted antibody-drug conjugate SHR-4849 in patients with relapsed small cell lung cancer (SCLC).

Paternal prepubertal exposure to passive smoke is associated with impaired lung function trajectories in their children, persisting from childhood into middle age and raising the risk of chronic obstructive pulmonary disease (COPD).

Children with asthma face a heightened risk of fractures, particularly when treated with corticosteroids, according to findings from a large nationwide cohort study.

GLP-1 receptor agonists (GLP-1RA) are emerging as a potential therapeutic option for patients with obstructive sleep apnea (OSA), according to a recent review that examined growing clinical evidence.

Telemedicine follow-up significantly improved quality of life and inhaler use techniques among patients with advanced chronic obstructive pulmonary disease (COPD), according to a randomized controlled trial.

Adults with psoriasis may be more likely to also have chronic bronchitis, according to new U.S. population-based findings.

Severe Legionnaires’ disease requiring intensive care unit (ICU) admission shows improved survival compared to earlier reports, according to a multicenter retrospective cohort study of French patients.

Rheumatoid arthritis associated interstitial lung disease (RA-ILD) is increasingly recognized as a major factor influencing long-term outcomes in affected patients, with new data showing that disease progression and specific lung patterns significantly impact mortality.

The addition of nivolumab to platinum-etoposide chemotherapy improved both progression-free and overall survival in patients with extensive-stage small cell lung cancer (ES-SCLC), according to results from the randomized Phase II ECOG-ACRIN EA5161 trial.

Emotional distress before treatment is strongly associated with poorer responses to immunotherapy in patients with advanced non-small cell lung cancer (NSCLC), according to new research.

The availability of elexacaftor–tezacaftor–ivacaftor (ETI) has been associated with a marked reduction in cystic fibrosis liver disease (CFLD) progression, according to a nationwide analysis.

Children from disadvantaged neighborhoods face a sharper increase in viral-associated asthma exacerbations when returning to school after summer, according to a new population-based analysis.

A Parkinson’s disease medication has demonstrated potent activity against Mycobacterium tuberculosis through a novel host-directed mechanism, offering a potential new avenue for combating the disease and addressing antimicrobial resistance.

High-flow nasal cannula (HFNC) therapy may significantly reduce the need for intubation in critically ill patients with Pneumocystis jirovecii pneumonia (PjP), according to a new multicenter retrospective analysis.

Interstitial lung disease (ILD) is independently associated with a significantly higher risk of developing lung cancer, according to new findings from a large population-based cohort study that controlled for genetic factors.

Only one in four patients with chronic rhinosinusitis (CRS) maintain full clinical control more than 5 years after endoscopic endonasal surgery (EES), according to new long-term follow-up data using the updated European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS) criteria.

Lung transplantation can be safely performed in men with newly diagnosed, localized high-risk prostate cancer prior to definitive cancer treatment, according to a new case review.

State-level restrictions on flavored e-cigarettes, implemented across several U.S. states, appear to have led to a decrease in e-cigarette use among young adults and older adults.

A novel, simplified loop-mediated isothermal amplification (LAMP) method for pneumonia pathogen detection has demonstrated significant potential for point-of-care applications in low-resource settings.

Slow-paced breathing (SB) significantly reduces state anxiety while enhancing brain activity, specifically in the midfrontal region, according to the results of a new study.

Post-acute sequelae of COVID (PASC), commonly known as long COVID, continues to affect millions globally, with over 18 million Americans impacted.

Noninvasive respiratory supports have become essential in the management of critically ill patients, especially those experiencing acute respiratory failure.

Between November 2020 and June 2022, the United States conducted predeparture COVID-19 testing for nearly 24,000 refugees.

Urinary volatile organic compounds (VOCs) may offer a non-invasive way to predict chronic obstructive pulmonary disease (COPD) risk, according to new findings from a national observational study using NHANES data.