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Prostate Cancer Upgrading Linked to Key Clinical Predictors

October 2026

A single-centre study found that elevated prostate-specific antigen density and perineural invasion were independently associated with Gleason score upgrading after radical prostatectomy in men initially diagnosed with Gleason 6 prostate cancer.

Prostate Cancer Upgrading Linked to Key Clinical Predictors

A single-centre study found that elevated prostate-specific antigen density and perineural invasion were independently associated with Gleason score upgrading after radical prostatectomy in men initially diagnosed with Gleason 6 prostate cancer.

Bladder Cancer Combination Shows Durable Response in Trial

ERBB2-positive bladder cancer showed a 73.1% complete response rate with combination therapy in a phase II trial.

Bladder stone surgery

Bladder Stone Surgery Registry Highlights Transurethral Success

A global registry of 805 patients found transurethral bladder stone surgery was the most common approach, offering high stone clearance and shorter hospital stays, while other techniques were reserved for more complex cases.

Fertility After Childhood Cancer Linked to Pubertal Hormone Levels

A study of 221 male childhood cancer survivors linked pubertal hormone levels with adult fertility outcomes, highlighting persistent impairment after radiotherapy and evidence of hormonal recovery after intermediate-dose chemotherapy.

Single-port robot-assisted radical prostatectomy

Single-Port Robotic Prostatectomy Shows Efficient Adoption

A learning curve analysis found that surgeons with prior Xi experience adopted single-port robot-assisted radical prostatectomy efficiently, achieving short operative times from the earliest cases.

Urine Methylation Assay Detects Urothelial Cancer

A multicentre study found a urine methylation assay accurately detected urothelial carcinoma and identified postoperative recurrences months before clinical confirmation.

Gepotidacin Linked to Rapid Symptom Improvement in Uncomplicated UTIs

Gepotidacin was associated with rapid symptom improvement in patients with uncomplicated urinary tract infections, with more than half improving within 24 hours.

Endoscopic Findings Fail to Predict Stone Recurrence

A five year analysis found stone recurrence in 35.1% of patients after ureteroscopic lithotripsy, with stone side emerging as the only independent predictor.

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