European Archives - Page 1225 of 1288 - European Medical Journal

Pacritinib therapy led to symptom improvement in myelofibrosis

The phase 3 PERSIST-1 study showed that pacritinib, a selective inhibitor of Janus Kinase 2 (JAK2) and Fms-Like Tyrosine Kinase-3 (FLT3), is more…

Treatment and outcome of CML patients from the EUTOS population-based registry

The European Treatment Outcome Study (EUTOS) investigated the treatment and treatment outcome of patients with chronic myeloid leukaemia (CML).

Venetoclax (ABT-199/GDC-0199) plus rituximab shows promise in relapsed/refractory CLL

n a phase 1b, open-label, dose-escalation, multicentre study of patients with relapsed or refractory chronic lymphocytic leukaemia (CLL), the combination…

Adding elotuzumab to standard treatment for myeloma reduced disease progression

ELOQUENT-2, a phase 3, randomised, open-label study of lenalidomide and dexamethasone with or without elotuzumab in patients with relapsed or refractory…

EMJ

Phase 3 CheckMate 067 trial of nivolumab in previously untreated advanced melanoma

At the 2015 American Society of Clinical Oncology (ASCO) Annual Meeting, James Larkin, FRCP, PhD, Consultant Medical Oncologist at The Royal Marsden…

EMJ

Whole Brain Radiation Therapy is More Harmful Than Beneficial for Small Brain Metastases

In the phase 3 NCCTG N0574 (Alliance) trial, patients with 1 to 3 small brain metastases were randomised to receive stereotactic radiosurgery (SRS) alone…

EMJ

Elective Neck Dissection Improved Survival in Early Node-Negative Oral Cancer

A phase 3, randomised controlled trial showed that elective neck dissection improved overall survival by 12.5% and reduced risk of death by 36% when…

EMJ

Improved Cancer Treatments Linked to Reduced Late Mortality in Childhood Cancer Survivors

Data from the Childhood Cancer Survivor Study (CCSS), a retrospective cohort study of children diagnosed with cancer from 1970–1999 at 31 participating…

EMJ

Combined Nivolumab and Ipilimumab or Monotherapy Shown Promise in Untreated Melanoma

The randomised, double-blind, phase 3 CheckMate 067 trial showed that nivolumab alone or nivolumab plus ipilimumab significantly improved progression…

EMJ

Novel JAK Inhibitor Pacritinib Proves Effective for Easing Symptoms of Myelofibrosis

Findings from the PERSIST-1 study of patients with myelofibrosis suggest that pacritinib is significantly more effective than best available therapy…