European Archives - Page 1307 of 1451 - European Medical Journal

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2 Mins
28 Jul 2016

GBT440, a Novel Sickle Haemoglobin Polymerisation Inhibitor, Increases Haemoglobin Oxygen Affinity and Results in a Rapid Improvement in Haemolysis and Anaemia

GBT440 is a novel, small molecule haemoglobin oxygen affinity modifier. In vitro data has shown that by increasing sickle haemoglobin (HbS) oxygen…
8 Mins
28 Jul 2016

New Insights in Bone Marrow Failure

Several rare haematological diseases are linked to bone marrow failure (BMF). This symposium provided the latest scientific insights into the different…
2 Mins
28 Jul 2016

Role of the Calreticulin Gene and Its Deregulation in Myeloproliferative Neoplasms

Polycythaemia vera (PV), essential thrombocythaemia (ET), and primary myelofibrosis (PMF) are the three classical Philadelphia chromosome-negative…
9 Mins
28 Jul 2016

Navigating the Changing Multiple Myeloma Treatment Landscape

The treatment landscape for patients with multiple myeloma (MM) is constantly evolving. Over the past decade, the introduction of novel agents including…
2 Mins
28 Jul 2016

Family-Directed Cord Blood Banking for Sickle Cell Disease: A 20-Year Experience on Behalf of Eurocord-Monacord and the International Sickle Cell Disease Observatory

Cord blood transplantation (CBT) from a related family member is an effective therapy for patients with sickle cell disease (SCD) resulting in…
9 Mins
28 Jul 2016

Editor’s Pick: Minimisation of Bleeding Risks Due to Direct Oral Anticoagulants

Direct oral anticoagulants (DOAC) are used in several indications for the prevention and treatment of thrombotic events. As highlighted by data from…
1 Mins
28 Jul 2016

Real-World Experience of Ibrutinib in More Than 700 Patients with Mantle Cell Lymphoma: Data from a Global Named Patient Programme

Mantle cell lymphoma (MCL) is an uncommon but aggressive form of B cell non-Hodgkin lymphoma. It often presents at an advanced stage and with a median…
9 Mins
28 Jul 2016

Bridging to Transplant in Diffuse Large B Cell Lymphoma

Non-Hodgkin lymphoma (NHL) is the eighth most common malignancy worldwide. Diffuse large B cell lymphoma (DLBCL) is the most frequent subtype, accounting…
9 Mins
28 Jul 2016

Thrombocytopenia Caused By Inherited Haematopoietic Transcription Factor Mutation: Clinical Phenotypes and Diagnostic Considerations

Inherited thrombocytopenias comprise a heterogeneous group of blood disorders with abnormalities in genes related to glycoproteins and adhesion molecules…
2 Mins
28 Jul 2016

The Spectrum of Late Effects After Cancer: Lessons from Paediatric Oncology and the Value of International Collaboration

This presentation described the occurrence of late side effects (commonly described as ‘late effects’) in childhood cancer survivors (CCS), and how…
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