Hema Now
In this episode of Hema Now, Cynthia Dunbar discusses her pioneering career in translational stem cell biology. From the evolution of haematopoietic stem cell research to the clinical milestones that have propelled gene therapy into mainstream haematology, Dunbar shares insights on innovation, collaboration, and the future of patient care.
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Cynthia Dunbar is a recently retired Chief of the Translational Stem Cell Biology Branch and now a distinguished National Institutes of Health (NIH) Investigator within the Intramural Research Program of the National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA. Dunbar’s research spans basic laboratory discovery through to early-phase clinical trials, with a focus on haematopoiesis, natural killer cell biology, haematopoietic stem cell and CAR-T cell gene therapies, and the pathophysiology and treatment of congenital and acquired bone marrow failure syndromes.
Timestamps:
00:00 – Introduction
01:35 – Origins in haematology research path
02:52 – Evolution of haematopoietic stem cell biology
06:35 – Milestones enabling gene therapy adoption
10:37 – Advances in bone marrow failure treatment
19:24 – Promise of natural killer (NK) cell therapies
24:09 – COVID-19 collaboration and crisis lessons
29:27 – Challenges in translational research pipeline
33:23 – Future breakthroughs transforming patient care
38:39 – Three wishes for research future
Disclaimer: The opinions expressed in this episode belong to the speakers and do not necessarily represent the opinions of EMJ.
