Hepatology

Tacrolimus was linked to lower mortality and rejection after liver transplantation, but carried a higher risk of diabetes.

Insulin resistance is independently linked to MASLD in type 1 diabetes, highlighting a distinct high-risk metabolic phenotype in affected patients.

US model study suggests a targeted hepatitis B birth-dose strategy could increase neonatal infections unless screening and vaccination remain high.

HBV reactivation risk increases after rituximab in lymphoma patients once antivirals stop, with most relapses occurring within the first year.

Alcohol intake changes influence liver disease progression, with reduced drinking linked to lower risk of liver-related events in steatotic liver disease.

Participatory medicine could reshape hepatology by involving the public, clinicians and AI to improve liver disease prevention, awareness and research engagement.

Wilson disease genetics gap is narrowing, with reanalysis and whole genome sequencing identifying previously missed ATP7B variants in most unresolved cases.

A ketogenic very low energy diet reduced liver fat by 77% in MASLD, outperforming a Mediterranean diet in a small randomised trial.

Gilbert syndrome in liver donors appears safe, with no impact on transplant outcomes or survival, according to a systematic review and meta-analysis.

Paediatric autoimmune liver disease shows high survival but limited complete biochemical control after one year of standard therapy in European registry data.

England reports progress towards hepatitis C elimination as prevalence falls, with diagnosis gaps and harm reduction challenges remaining.

Hepatitis E infection affected 3.5% of transplant patients, with high chronicity in those infected and treatment and screening key to care.

Global efforts to tackle viral hepatitis are insufficient, leaving millions at risk and far from 2030 elimination goals.

Paediatric autoimmune hepatitis incidence in Denmark has surged, yet most children maintain liver function with standard immunosuppressive therapy.

Underreported alcohol use masks alcohol-related liver disease, increasing misclassification and obscuring true mortality rates.

Telemedicine nutrition care reduces MASLD and liver disease risk in adults with type 2 diabetes and obesity, showing promise for lifestyle-first interventions.

In a northern Mexico cohort, MASLD now accounts for the largest share of chronic liver disease and cirrhosis cases.

Normothermic machine perfusion allows clinicians to assess high-risk livers from donors after circulatory or brain death before transplantation.

Sudan faces an outbreak of acute hepatitis among displaced populations, with severe liver complications in vulnerable communities.

Obesity drives liver disease progression, with new therapies and weight-loss strategies offering hope for improved outcomes in MASLD and MASH.

Advanced chronic liver disease is driven by portal hypertension. Explore how beta-blockers like carvedilol may help manage risk and delay decompensation.

The FIB-4 index may not reliably detect liver fibrosis in MASLD, with high false-positive and false-negative rates, highlighting challenges for primary care screening.

Menstrual recovery after liver transplantation may indicate better graft liver health, as women whose periods returned were far less likely to develop liver complications.

New study finds cfDNA fragmentome analysis can detect liver disease early, identify fibrosis and cirrhosis, and even predict survival across illnesses.

Mouse study finds impaired ammonia clearance can accelerate hepatocellular carcinoma growth and highlights potential dietary strategies to slow tumours.

Post-COVID chronic liver complications, including fibrosis and cirrhosis, have been reported months after infection, highlighting long-term risks.

Multicentre study in South America suggests MASLD is a leading cause of cirrhosis, highlighting rising metabolic risk factors and gender-balanced insights.

Abnormal Wnt signalling may drive a rare, high-risk childhood liver cancer and influence chemotherapy response, new research suggests.

Genetically higher FGF21 levels were associated with lower problematic alcohol use, fewer binge episodes, reduced weekly alcohol intake, and lower ARLD risk.

HBV vaccination rates among infants in the USA have fallen by more than 10 percentage points in the past two years.

A new blood test accurately identifies serious scarring in patients with liver disease, a 2026 cohort study has found.

Since high levels of alanine aminotransferase are a significant biomarker of liver injury, this analysis points to the benefits of resistance exercise in patients with MASLD, which led to a noticeable decline in alanine aminotransferase levels.

A new point-of-care fingerstick test detects HBV within one hour, a 2026 diagnostic accuracy study has found.

Unscheduled care attendance data provides an opportunity to identify patients at high risk of liver disease, a 2026 study has found.

The risk of MASLD increases following menopause before the age of 50, according to a 2026 global cohort study.

Combining AI-processed CECT with clinical data improves the management of unresectable hepatocellular carcinoma, a 2026 study has found.

New data suggest MASLD overlap alters pruritus and fatigue severity in primary sclerosing cholangitis, with implications for symptom monitoring in hepatology practice.

Novel non-invasive liver disease assessments (NILDAs) are effective liver biopsy alternatives for fibrosis, a 2026 systematic review has found.

Matched targeted treatment significantly improved overall survival in advanced cholangiocarcinoma in the Italian ANITA real-world dataset.

New study shows age predicts six-week mortality in cirrhotic patients after acute gastrointestinal bleeding, with potential to improve risk stratification.

New research shows that bacteria normally found in the mouth can travel to the gut and promote liver scarring by damaging the gut barrier.

A global report shows uneven progress toward WHO hepatitis elimination goals, highlighting persistent policy and implementation gaps in testing and treatment.

A new study shows that the triglyceride-glucose-waist-to-height ratio may help predict NAFLD risk in older adults, offering a simple screening tool.

New research suggests a blood-based test could improve early detection of liver cancer in high-risk patients.

New data show that alcohol-related liver disease continues to drive liver mortality, even where overall alcohol consumption has declined.

New research suggests that abnormal sleep duration may be associated with increased risk of chronic liver disease, particularly in people with metabolic risk factors.

A new global report shows uneven progress towards viral hepatitis elimination, with major gaps in diagnosis and treatment contributing to ongoing liver-related deaths.

New research has identified a liver-specific receptor, GPR110, as a key driver of sex-related differences in the progression of metabolic dysfunction-associated steatohepatitis.