Hepatology

The model analyses demographic information, lab results, and other clinical data to predict the cause of graft injury across six possible conditions.

This new study highlights the growing role of extracellular volume measurement using spectral CT, which quantifies the proportion of extracellular matrix.

The findings support the concept that excessive lipogenesis, rather than just fat delivery from other sources, is central to MASLD development.

A study has revealed that pemafibrate is more effective than omega-3 fatty acid ethyl in reducing fatty liver index.

Discover a study that suggests that dual therapy could offer a safer and more effective approach to treating MASLD.

A recent study investigated how different naturally occurring fibrinogen variants relate to obesity, MASLD, and liver fibrosis severity.

PLAN-B-DF was trained and internally validated on a large cohort of 5,585 patients, and externally validated.

A recent nationwide Swedish cohort study involving over 13,000 patients with MASLD compared mortality rates and causes of death.

Breastfeeding, known for its metabolic benefits to both parent and infant, is encouraged in those with MASLD.

Discover a study that explored the use of faecal calprotectin as a biomarker for sepsis in liver dysfunction. Learn more.

A recent study offers new insight into the prevalence and implications of steatotic liver disease in older adults.

A new retrospective study has proposed a predictive model for cirrhosis and hepatocellular carcinoma in individuals with haemochromatosis.

The study raises important concerns about the long-term mental health of individuals with resolved HBV infection.

Timely public health policies targeting key metabolic conditions can reduce the global burden of MASLD.

The findings suggest that lifestyle factors beyond alcohol, such as diet and physical inactivity, may play a more substantial role in fatty liver development.

The study concludes that ED-based opt-out testing is both effective and acceptable in detecting hepatitis.

The study concludes that decentralised and person-centred hepatitis screening is effective and essential.

A new study sheds light on the role of CD4 T cell autophagy, a cellular recycling process, in the progression of liver fibrosis.

This research highlights the importance of innovative blood-based diagnostics in bridging current gaps.

Notably, the study found that bariatric surgery was cost-effective based on the incremental cost-effectiveness ratio.

A nationwide retrospective cohort study was conducted to assess the impact of population size on waiting list outcomes for patients with acute liver failure.

Discover a new study that combined selective internal radiation therapy with nivolumab for patients with HCC.

Compared to controls, the rhTPO group experienced fewer bleeding events and a lower mortality rate.

A recent study explored the combined impact of oral nutritional supplementation and probiotics on gut microbiota and liver function.

A recent study highlighted the potential benefits of digital health interventions in improving physical recovery for patients with primary liver cancer.

A key finding was the significant increase in serum UDCA levels in the aerobic group.

This recent study assessed the potential of urinary biomarkers to predict patient mortality in cirrhotic individuals.

Discover new research on how liver disease affects circadian rhythms. Learn more.

While effective therapies exist, challenges remain in managing acute liver failure, where transplantation may be life-saving.

CT could also help assess fatty liver using advanced tools such as 3D automated volumetric analysis.

Recent studies have identified a gene signature known as the senescent hepatocyte gene signature that tracks with MASLD progression.

The “wine mum” culture, which normalises excessive alcohol consumption, further perpetuates harmful drinking behaviours.

Discover a project that designed EchoNet-Liver, a deep-learning computer-vision pipeline to cirrhosis and steatotic liver disease.

A recent study analysed CT imaging findings from 48 pathologically confirmed cases of hepatic CE.

A Phase 2 clinical trial finds that ALT flares are common in hepatitis D patients treated with pegylated interferon-alpha, but pose no safety risk, and may even signal better viral response.

This study aimed to explore anxiety trends among HCV-infected people who inject drugs.

A recent first-in-human gene therapy trial using DTX401 has shown promising results in improving glucose homeostasis.

The findings demonstrated a clear reduction in psychological distress and sleep disturbances among patients who received targeted nursing care.

An ideal ventilation support mode should enhance patient-ventilator interaction while minimising asynchronies and haemodynamic disturbances.

Chitosan, a dietary fibre derived from chitin in fungi, mushrooms, and crustaceans, has shown potential for weight and fat reduction.

Methods like preoperative time-outs improve communication but can lead to information overload.

Recent developments in machine learning have allowed researchers to reconstruct long-term disease patterns.

A large-scale study finds that the hepatitis E vaccine HEV 239 significantly reduces the risk of symptomatic hepatitis E among individuals with chronic hepatitis B.

The connection between Type 2 diabetes and NAFLD is primarily driven by insulin resistance, which increases free fatty acid levels.

Time-restricted feeding (TRF), limits food intake to a set daily window, such as the 16:8 model.

Mitochondrial impairment is a key factor in MASLD and MASH development, affecting oxidative capacity and energy homeostasis.

Overall, the global hepatitis A landscape has evolved due to shifting transmission routes and pandemic responses.

A clinical trial found that pomegranate peel extract improves liver enzymes, triglycerides, and inflammation markers in NAFLD patients.

These findings challenge existing practices in some institutions that administer prophylactic anticoagulation after liver transplantation.

The study suggests that rencofilstat 225mg/d improves both liver function and portal-systemic shunting in patients with MASH.

Flaxseed powder improves liver fat, metabolism, and gut health in NAFLD patients, offering a natural dietary solution.

Increased copper activity contributes to ageing-related oxidative stress, but targeted chelation therapy may offer a promising intervention.

To improve screening efficiency, it is crucial to identify patients with elevated hepatocellular carcinoma risk while sparing low-risk individuals from unnecessary procedures.

A randomised controlled trial showed that adding reduced glutathione to entecavir therapy can significantly improve liver function, reduce fibrosis, and enhance HBV-DNA clearance in chronic hepatitis B patients.

Immunotherapy, targeted radiation, and a refined surgical technique allowed tumour removal in a liver cancer patient previously ineligible for surgery.

Findings suggest that combining simvastatin and rifaximin does not offer a clinically meaningful advantage in preventing severe complications in patients with decompensated cirrhosis.

Even low levels of air pollution can cause liver inflammation, fibrosis, and metabolic changes linked to fatty liver disease.

cCR predicts survival outcomes in unresectable hepatocellular carcinoma, providing a valuable marker for treatment response and prognosis.

This study revealed an association between elevated hepatic histamine levels, mast cell infiltration, and erythropoietic protoporphyria progression.

Non-selective β-blockers have demonstrated significant potential in preventing decompensation.

By integrating advanced imaging, digital pathology, and molecular analysis, research can refine fibrosis staging and treatment approaches.

A new model predicts HCC risk in noncirrhotic CHB patients, focusing on HBV DNA levels and other key factors.

A clinical trial was conducted to evaluate the efficacy and safety of autologous HBV vaccine-pulsed dendritic cells and their induced T cells.

Data from 22 studies, encompassing 756,088 subjects, including 62,072 Hispanic adults, revealed striking findings.

Alcohol consumption exacerbates the risk of cirrhosis and hepatocellular carcinoma, promoting hepatitis B virus replication and weakening immunity.

Inflammatory and oxidative processes underpin the connection between high Haemoglobin Glycation Index and disease progression.

Lifestyle interventions, particularly achieving a weight loss of over 10%, have been shown to resolve MASH.

A 96-week study finds bulevirtide safe and effective for HDV-related cirrhosis, improving liver health and reducing complications.

Low donor fasting glucose predicts poorer outcomes after LDLT, highlighting its potential as a prognostic marker.

A Mediterranean diet, rich in whole grains, vegetables, fruits, nuts, and olive oil, is proven to improve liver health by reducing inflammation and fat accumulation.

The tool’s performance was consistent across multiple validation cohorts, though accuracy varied slightly, especially when dealing with different patient populations.

The study’s findings demonstrate that hypovolaemic phlebotomy effectively reduces the need for red blood cell transfusions.