Oncology

Regional nodal irradiation in breast cancer showed low recurrence rates after nodal pCR, even when residual breast disease remained.

Psychological interventions for parents in pediatric palliative care improved short term mental health outcomes.

A nurse-led bladder management approach improved bladder volume reproducibility and reduced repeat imaging in prostate hypofractionated radiotherapy.

Sjögren’s disease linked to higher cancer risk in patients and close relatives in this cohort study.

Prostate biopsy under local anesthesia showed similar safety and detection outcomes, with better comfort trends for transperineal sampling.

Narrative-based palliative care reduced stress and improved quality of life in elderly terminal cancer patients and families.

Older adults with frailty often faced prolonged functional recovery and unmet care needs after major elective noncardiac surgery.

Sustainable breast cancer surgery was feasible in a pilot study, with high sentinel node detection rates preserved.

A new review has highlighted the gut microbiota as a potential systemic driver of liver metastasis in small cell lung cancer, shifting attention beyond tumor genetics alone to the gut liver axis.

Radiologic exposomics may help reveal how environmental exposures shape cancer biology through imaging biomarkers.

Exercise was associated with reduced cancer-related lymphedema risk, with meta-analysis showing a 29.0% relative reduction overall.

Cancer after cardiac surgery was tied to shorter long-term survival, even though in-hospital mortality remained low.

Transplant oncology is expanding liver transplantation for some cancers pairing downstaging therapy with strict selection criteria.

Cervical cancer screening disparities persist for African-immigrant women in the United States, highlighting barriers and care-gaps.

Nordic data link gastric bypass to rare, excluded stomach cancer, with risk rising after 10 years and diagnosis potentially delayed.

Prior cesarean delivery was linked to higher postmolar gestational trophoblastic neoplasia risk, without increased chemoresistance overall.

An AI-enabled vibrating capsule detected abnormal bowel tissue, by stiffness signals, hinting at colorectal cancer screening tests.

Rectal cancer surgery triggers perioperative microbiome shifts, with lower diversity plus increased Enterococcus and Streptococcus.

Robotic secondary cytoreductive surgery enabled rapid complete removal of three extrapelvic ovarian cancer recurrences in one case.

Polycyclic aromatic hydrocarbons in charcoal grill smoke reached extreme levels during pork belly cooking, researchers report.

New guidance details valuable approaches to analyze longitudinal patient-reported outcomes when many patients die during follow-up.

A qualitative review shows informal caregivers adapt feeding for children with cancer, often straining home routines and wellbeing.

Patient integration in oncology research can align therapies with needs by translating science into outcomes patients value, today.

Gut microbiota dysbiosis may shape colorectal cancer risk, with microbial signatures emerging as non-invasive screening biomarkers.

In lung cancer screening eight-session counseling with short-course nicotine replacement therapy delivered the best value per quit.

New nomograms improved survival prediction for acute erythroid leukemia, highlighting age and chemotherapy as factors nationwide.

Shoulder joint range of motion fell markedly 1 month after breast cancer surgery in Japan despite routine inpatient rehabilitation.

US cost-effectiveness analysis showed durvalumab in limited-stage small cell lung cancer improved survival but exceeded thresholds.

Six-year FROST trial data suggest cryoablation can durably control Stage I breast tumors, with low recurrence reported overall.

Synthetic lethality could counter cancer drug resistance by targeting tumor vulnerabilities that appear after treatment pressures.

Medicaid eligibility restrictions may contribute 1 million missed cancer screenings and advanced stage diagnoses, models suggest.

Neratinib markedly reduced vascular inflammation and atherosclerosis in mice by targeting ASK1, boosting effects with rosuvastatin.

Selenium modulated redox signaling in renal cell carcinoma cells, shifting reactive oxygen species and survivability trajectories.

Peripheral inflammatory cell counts were linked to depression prevalence in NHANES adults with a history of solid tumors.

Very high-risk prostate cancer predicted shorter survival than high-risk disease in nonmetastatic patients managed without surgery.

HPV self-collection education materials can boost screening confidence when language, visuals and inclusivity address key concerns.

Adult childhood cancer survivors demonstrated accelerated brain aging that tracked with cranial radiation and poorer neurocognition.

Cancer diagnosis was linked to cardiovascular disease mortality in UK Biobank, implicating inflammation and coagulation proteins.

Robotic surgery shortened hospital stay versus laparoscopy for obese patients with colorectal cancer, with comparable safety overall.

Neoadjuvant chemo-reirradiation alongside IOERT surgery produced manageable toxicity, and 75.7% two-year survival in patients with LRRC.

Host-related determinants of immunotherapy response in NSCLC hinge on body composition, metabolism, sex, and systemic inflammation.

An analysis confirms dual enrollment at private and safety-net hospitals is feasible for Phase I solid tumor trials, yielding higher diversity and similar patient survival rates.

Cancer clinical trials development in Latin America underperforms globally yet strengths could expand equitable evidence worldwide.

FT-IR microspectroscopy blood test detected a single circulating tumor cell in one patient with lung cancer, cytospun raw blood sample.

Patients with cancer given access to free acupuncture and massage treatments at a community center in East Harlem, New York, reported symptom relief and broad satisfaction with services in an evaluation study.

Male circumcision is associated with lower odds of women developing various cervical lesions, according to a systematic review and meta-analysis.

Insurance coverage influences quality of life outcomes for women with early-stage estrogen receptor positive breast cancer.

Real-world study shows GLP-1 use in breast cancer linked to clinical factors, social determinants, and ctDNA.

Early MRI predicts pathologic complete response and long-term outcomes in TNBC patients receiving pembrolizumab.

SABCS 2025 data show frequent biomarker changes in inflammatory breast cancer after neoadjuvant therapy.

New SABCS data reveal racial and socioeconomic disparities in metastatic HR+ breast cancer presentation and treatment timing.

For patients with head and neck cancer receiving radiation therapy, dysphagia can emerge early and persist as a chronic or late complication.

Pilot data suggest biosynthetic mesh breast reconstruction may offer acceptable outcomes for high-risk implant candidates.

PARP inhibitor maintenance therapy improved progression free survival in newly diagnosed advanced ovarian cancer but not survival.

Propensity matched data suggest robotic minimally invasive esophagectomy offers shorter hospital stay after neoadjuvant therapy compared with open approaches.

User-centered digital solutions may ease care pathways for plastic surgery patients with non-melanoma skin cancer.

New analysis of U.S. adults shows a marked gender gap in cancer-free life expectancy.

Age-based lung cancer screening could detect far more cases than current US risk-based eligibility criteria.

Treatment goals in older adults with acute myeloid leukemia now prioritize long-term survival with targeted regimens.

Perioperative corticosteroid use significantly reduced postoperative seroma formation in patients undergoing breast cancer surgery.

Prostate cancer screening remains inconsistent in U.S. primary care, even for men at clearly elevated risk.

Drug repurposing in oncology may accelerate immunotherapy by reusing familiar agents to reshape antitumor immunity.

Baseline quality of life at diagnosis was strongly associated with survival outcomes in patients with non-metastatic advanced pancreatic cancer.

Lung cancer clinical trial participation remains markedly low and varies significantly according to care setting and patient-level factors.

The COVID-19 pandemic was associated with distinct, long-term changes in cancer incidence between males and females.

Adults with colorectal cancer and colostomy reported significantly poorer health-related quality of life overall than peers.

Artificial neural networks stratified adults with head and neck cancer after chemoradiation using routine clinical data.

Immune checkpoint inhibitor therapy appears safe and effective for NSCLC in people living with HIV today.

Automating cancer registries promises efficiency gains but demands rigorous design privacy safeguards, and ongoing human oversight.

Higher BMI and thicker breast subcutaneous fat were linked to more malignant ultrasound characteristics in breast cancer.

Postdiagnosis statin use was associated with a modest but measurable reduction in breast cancer-related deaths among women with early-stage disease.

Persistent depression during adjuvant cancer therapy heightens treatment toxicity and significantly worsens overall QoL in early-stage cancer.

Prolonged sitting increases mortality risk in cancer survivors, but a healthy diet may significantly reduce that risk.

Transitions in care for patients with head and neck cancer remain a critical challenge, with new research revealing substantial evidence gaps.

Neurocognitive functioning declines across central nervous system cancers, shaped by tumor location and interacting treatment effects.

Cannabis laws were associated with lower opioid dispensing among commercially insured patients with cancer across U.S. states.

Melanoma quality of life differs during and after immunotherapy, with fatigue, skin issues, and sexual dysfunction.

The six-minute walking test offers an objective, low-cost assessment of postoperative recovery after pancreatic surgery.

High-risk women had limited awareness yet strong support for breast cancer polygenic risk scores in clinical risk assessment more.

Health-related quality of life remains significantly underreported in trials evaluating tyrosine kinase inhibitors and immune checkpoint inhibitors for early-stage non-small cell lung cancer.

A multimodal AI model has achieved significant advances in pan-cancer prognosis prediction by combining pathology images, genomics, and clinical data.

Survivors of childhood cancer face a heightened risk of developing severe valvular heart disease many years after completing treatment.

High-quality colposcopy training is vital to global efforts to eliminate cervical cancer, yet many healthcare systems face significant training gaps.

Immunotherapy may offer meaningful benefit for patients with combined small-cell lung cancer, a rare and aggressive tumor subtype that has historically lacked clear treatment strategies.

Women with hereditary cancer syndromes face complex decisions that weigh the benefits of ovarian cancer prevention against the potential long-term risks of cardiovascular disease.

Colonic stenting for obstructing colorectal cancer can be performed with acceptable radiation exposure while offering patients a strong chance of avoiding stoma formation, according to new findings.

Invasive gastric cancer may develop in distinct patterns after eradication of Helicobacter pylori, with endoscopic surveillance revealing unique clinical characteristics compared to intramucosal gastric cancers.

Advances in early detection, prevention, and treatment are reshaping the outlook for pancreatic cancer, one of the deadliest malignancies worldwide.

Patients with unresectable pancreatic cancer who receive second-line treatment with nanoliposomal irinotecan in combination with fluorouracil and folinic acid may remain eligible for subsequent third-line chemotherapy.

Clinical cancer research across the Asia-Pacific region faces substantial barriers, with competing demands, lack of funding, and limited infrastructure emerging as the most significant obstacles, according to a large cross-sectional survey of healthcare professionals.

Machine learning can help predict urgent care visits in patients with non–small cell lung cancer receiving systemic therapy.

Long-term head and neck cancer survivors frequently report poor oral health-related quality of life, with persistent late toxicities remaining common more than 8 years after diagnosis.

AI is rapidly transforming oncology, but many clinicians lack practical tools to evaluate its real-world reliability.

Acute diarrhea during chemoradiotherapy for anal cancer is significantly more likely among patients treated with 5-fluorouracil (5-FU) or capecitabine compared with those receiving cisplatin or radiotherapy alone, according to new findings.

Overall survival in the Asia cohort of the Phase III MARIPOSA study has been reported to favor amivantamab combined with lazertinib compared with osimertinib monotherapy in patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC).

Timely initiation of postoperative radiation therapy (PORT) within 6 weeks of surgery is a critical factor in improving outcomes for patients with head and neck squamous cell carcinoma.

Ocular toxicities are an emerging challenge in the management of gynecologic cancers treated with antibody drug conjugates, with new research outlining prevention and care strategies to safeguard patient outcomes.

A new real-world study has mapped the treatment landscape for mantle cell lymphoma (MCL) in Japan, highlighting common patient characteristics, therapeutic strategies, and ongoing gaps in efficacy and quality of life outcomes.

Confirmatory testing for men with low-risk prostate cancer increased steadily in recent years, but a payment incentive program was not linked to a statistically significant improvement in its use, according to a large cohort study.

Greater familiarity among surgical teams significantly improves outcomes in renal, bladder, and prostate cancer procedures, according to a new study assessing team membership and cohesion.

TAR-200, an investigational intravesical drug-releasing system delivering sustained gemcitabine, demonstrated high response rates and durable outcomes in patients with bacillus Calmette-Guérin (BCG)–unresponsive high-risk non–muscle-invasive bladder cancer (NMIBC), according to results from the Phase IIb SunRISe-1 study.

Patients with chronic lymphocytic leukemia (CLL) who consistently saw the same oncologist or hematologist experienced significantly fewer emergency room visits and hospitalizations, according to a large real-world study of nearly 6,000 individuals treated with covalent Bruton tyrosine kinase inhibitor (cBTKi) therapy.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), widely used for diabetes and weight reduction, may offer significant benefits in improving outcomes for patients with non-small cell lung cancer (NSCLC), according to new clinical and preclinical evidence.

Immunotherapy combined with standard neoadjuvant chemotherapy has shown encouraging benefits in hormone receptor positive, HER2 negative early breast cancer, according to new evidence.

The addition of nivolumab to platinum-etoposide chemotherapy improved both progression-free and overall survival in patients with extensive-stage small cell lung cancer (ES-SCLC), according to results from the randomized Phase II ECOG-ACRIN EA5161 trial.

Frequent ibuprofen use was associated with a reduced risk of endometrial cancer, while aspirin showed no measurable effect, according to a large cohort analysis of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.

Pediatric central nervous system (CNS) tumors remain among the most fatal childhood cancers, largely because the blood-brain barrier (BBB) restricts effective therapeutic delivery and worsens clinical outcomes.

A Phase I trial of a pancreatic cancer vaccine targeting mutant KRAS has demonstrated durable immune responses and promising survival outcomes in patients with minimal residual disease following standard treatment.

A large population-based case–control study has found that a history of malignant melanoma (MM) does not increase the likelihood of developing vitiligo in the general population, with a notable exception in the Arab minority.

Patients with psoriasis initiating biologic therapy, particularly tumor necrosis factor (TNF) inhibitors, may have a reduced long-term risk of developing primary malignancies compared with biologic-naïve individuals, according to a large retrospective cohort study.

Interstitial lung disease (ILD) is independently associated with a significantly higher risk of developing lung cancer, according to new findings from a large population-based cohort study that controlled for genetic factors.

Robotic-assisted techniques could one day enhance the precision of Mohs micrographic surgery (MMS) for rare cutaneous sarcomas such as dermatofibrosarcoma protuberans (DFSP), but current technology remains ill-suited for skin-level applications, according to recent research.

Chimeric antigen receptor (CAR) immunotherapies are rapidly advancing beyond hematologic cancers, with new generations of CAR constructs and immune cell platforms showing promise across a wide spectrum of diseases.

Lung transplantation can be safely performed in men with newly diagnosed, localized high-risk prostate cancer prior to definitive cancer treatment, according to a new case review.

Sexual well-being of spouses of patients with colorectal cancer living with an ostomy is significantly impacted, with new research highlighting a critical gap in supportive care that fails to consider the emotional and intimate needs of partners.

The bladder microbiomes of women diagnosed with gynecologic cancer are strikingly similar to those of women without such a diagnosis, according to new research.

A groundbreaking study has leveraged novel machine learning algorithms to predict the five-year postoperative survival of patients with Stage III colorectal cancer (CRC), providing healthcare professionals with a powerful tool for personalized treatment planning.

A pilot study has revealed promising results for blue light photobiomodulation in treating complicated postsurgical breast wounds, with significant improvements in healing times and reduced complication severity.

Obese women who spend extended hours sitting each day may face an increased risk of developing breast cancer, according to a recent nationwide study.

In a groundbreaking study evaluating intraoperative radiotherapy (IORT) as a tumor bed boost with whole-breast irradiation (WBI) for patients with breast cancer undergoing breast-conserving surgery (BCS), researchers found that the combination approach offers promising safety and efficacy outcomes.