Rheumatology

Patients with autoimmune rheumatic diseases face significantly greater risks of complications after undergoing endovascular interventions for lower extremity arterial disease, according to a large U.S. inpatient analysis.

Pain and fatigue are among the most disabling symptoms in systemic sclerosis, and new evidence highlights the promise of non-drug strategies to ease their impact on daily life.

Predicting long-term kidney outcomes in patients with ANCA-associated vasculitis (AAV) may be improved by integrating additional clinical markers into existing risk models, according to new research.

Canakinumab demonstrated significantly greater efficacy and durability than anakinra in the treatment of patients with VEXAS syndrome, according to findings from an international multicenter study.

The global burden of psoriasis among adolescents and young adults has increased steadily over the past three decades, with projections indicating further acceleration through 2035.

Surgeons treating patients with unexplained pain after knee arthroplasty face profound clinical and emotional challenges, according to a new qualitative study that highlights the complexity of decision-making in this setting.

Cutaneous vasculitis in primary Sjögren disease is linked to significantly worse outcomes, particularly when cryoglobulinemic vasculitis is present, according to findings from a large multicenter cohort study.

A new survey highlights that patients with rheumatoid arthritis want faster and more personal access to rheumatology telephone advice lines, underscoring the growing strain on these services.

Bone mineral density (BMD) assessment using radiofrequency echographic multispectrometry (REMS) shows that age, sex, and BMI remain the strongest determinants of bone health, even in the context of total hip replacement surgery.

A new real-world study has mapped the treatment landscape for mantle cell lymphoma (MCL) in Japan, highlighting common patient characteristics, therapeutic strategies, and ongoing gaps in efficacy and quality of life outcomes.

Targeting IL-6 signaling shows reassuring safety and effectiveness in older patients with rheumatoid arthritis (RA), according to recent postmarketing and registry data.

Salivary gland ultrasound (SGUS) demonstrated meaningful diagnostic value for patients with highly suspected Sjögren’s Disease (SjD), particularly when combined with established serological or biopsy measures, according to findings from a prospective monocentric study.

ChatGPT demonstrates higher accuracy and completeness than Google Web Search when providing information about biologic therapy for systemic lupus erythematosus (SLE), according to a new comparative study.

Rheumatoid arthritis associated interstitial lung disease (RA-ILD) is increasingly recognized as a major factor influencing long-term outcomes in affected patients, with new data showing that disease progression and specific lung patterns significantly impact mortality.

New findings highlight that underlying rheumatic diseases may play a significant role in ischemic stroke among younger adults, emphasizing the importance of early diagnosis and referral.

Stiffness and swelling were identified as the most reliable clinical indicators distinguishing psoriatic arthritis from non-inflammatory musculoskeletal conditions in patients with psoriasis, according to a retrospective review from a combined rheumatology-dermatology clinic.

Power Doppler ultrasound may provide important signals in predicting treatment response for patients with rheumatoid arthritis (RA), though its ability to forecast remission remains uncertain, according to a new systematic review.

IL-1 pathway inhibition is increasingly replacing corticosteroids as the preferred second-line treatment for recurrent pericarditis, according to real-world registry data from the RESONANCE study.

Ultrasound imaging may offer a more precise way to distinguish between inflammatory and non-inflammatory phenotypes in patients with difficult-to-treat psoriatic arthritis (D2T-PsA), according to new multicentre cross-sectional study findings.

Recent advancements in machine learning (ML) are offering new opportunities to predict the onset and progression of knee osteoarthritis with greater accuracy, supporting earlier intervention and more personalized care.

New research has identified clinical features that may predict resistance to colchicine in patients with the syndrome of undifferentiated recurrent fever (SURF), offering potential guidance for more targeted treatment approaches.

A new bibliometric study highlights the rapid rise in artificial intelligence (AI) research within rheumatology, revealing both the field’s growing significance and the limited group of authors driving this trend.

A new interdisciplinary cardio-rheumatology model is paving the way for earlier detection and personalized treatment of cardiac complications in patients with systemic sclerosis, according to a recent review.

Retroperitoneal fibrosis (RPF) complicated by fibrosing mediastinitis (FM) is an uncommon but life-threatening condition that warrants early detection and intervention.

A recent systematic review and meta-analysis have highlighted the enhanced diagnostic ability of contrast-enhanced ultrasound (CEUS) over traditional Doppler ultrasound (DUS) for identifying active synovitis in patients with rheumatoid arthritis (RA).

Maternal smoking during pregnancy, as well as DNA methylation (DNAm) smoking scores, may be associated with a reduced risk of islet autoimmunity (IA) and type 1 diabetes (T1D) in children at high risk, according to the results of a new study.

A concerning increase in the incidence of central nervous system (CNS) demyelination among patients undergoing biologic treatments for rheumatologic diseases has been revealed by a new study.

Maintaining an INR between 2.5 and 3.5 may significantly reduce the risk of recurrent thrombotic events in patients with primary antiphospholipid syndrome (APS), particularly arterial events, according to a new retrospective study.

A new multicomponent vaccine targeting both seasonal influenza and SARS-CoV-2 has demonstrated noninferior immunogenicity and acceptable safety in adults aged 50 years and older, according to results from a Phase III randomized trial.

Menopause status significantly shapes the clinical presentation of systemic sclerosis (SSc), according to new findings from a multicenter analysis of over 1,500 women enrolled in the SPRING-SIR registry.

A new comparative analysis of international guidelines for psoriatic arthritis (PsA) management reveals key divergences in treatment strategies across leading rheumatology societies, underscoring ongoing challenges in global consensus despite shared therapeutic goals.

In a new multicenter study, researchers found that the effectiveness of a computerized patient decision aid (PtDA) for systemic lupus erythematosus (SLE) hinges not on where or how it is used but on whether patients view it fully and without interruptions.

Muscle impairments are a significant yet understudied burden in patients with osteogenesis imperfecta (OI), with consequences that extend far beyond bone fragility.

Lupus nephritis recurrence after kidney transplant may occur silently and more frequently than previously recognized, according to a new multisite retrospective study using both surveillance and indication biopsies.

Screening for latent tuberculosis (TB), hepatitis C virus (HCV), and occult hepatitis B virus (HBV) is critical before initiating biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in patients with rheumatoid arthritis (RA), according to a recent clinical audit conducted in Pakistan.

A new study suggests that mixed rhinitis (MR) may be a significantly underrecognized condition in children and adolescents previously diagnosed with allergic rhinitis (AR), with nearly half of patients potentially misclassified.

Stem cell–based therapies may offer a transformative approach for systemic sclerosis, according to a new review that evaluates both current limitations and emerging solutions in regenerative treatment.

New research provides critical insights into the phenotypic clusters of pediatric Behçet’s disease, highlighting the complexity and variability of clinical presentations in children with this rare inflammatory condition.

SEX significantly influences the onset, severity, and progression of systemic lupus erythematosus (SLE), according to a new scoping review that synthesizes data from nearly a decade of clinical research.

Patients with type 2 diabetes treated with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may face an increased risk of developing certain autoimmune diseases compared with those on dipeptidyl peptidase-4 inhibitors (DPP-4is), according to new real-world evidence from a large U.S. cohort.

Genetic risk scores for knee osteoarthritis do not predict disease progression, new cohort study reveals.

Vestibular dysfunction and impaired balance may be more common in patients with primary Sjogren’s syndrome than previously understood, according to new research exploring the condition’s neurological impact.

In a new cross-sectional study, methotrexate intolerance in patients with rheumatoid arthritis (RA) was not significantly associated with dosing frequency or route of administration, according to new findings.

As cancer therapies evolve and autoimmune diseases become more prevalent, the intersection of oncology and rheumatology, onco-rheumatology, is emerging as a critical field demanding transdisciplinary care.

European researchers are pioneering a shift in psoriatic arthritis (PsA) care through the integration of digital tools, explainable AI, and personalized health solutions, paving the way for earlier detection and more tailored treatment strategies in complex rheumatologic conditions.

Autoimmune thyroid disorders are significantly more common in patients with systemic lupus erythematosus (SLE), but they do not appear to worsen disease outcomes, according to a recent case-control study.

Cognitive behavioral therapy (CBT) and mindfulness may offer sustained reductions in pain and disability for adults with non-specific chronic low back pain, according to a new systematic review and meta-analysis of 75 randomized controlled trials encompassing over 15,000 participants.

In a major new study of over 350,000 individuals, researchers have uncovered compelling evidence that patients with rheumatoid arthritis face a significantly higher risk of developing active pulmonary tuberculosis, even in modern healthcare settings where tuberculosis screening precedes biologic treatment.

Early geriatric assessments in older adults with hip fractures are strongly associated with improved recovery, reduced hospital stays, and lower complication rates, according to a new systematic review.

A new systematic review has found limited and inconsistent evidence for the effectiveness of current fatigue-reducing interventions in children and adolescents with pediatric rheumatic diseases (PRDs), underscoring the urgent need for more rigorous and targeted clinical research.

Spondyloarthritis (SpA) classification criteria show variable diagnostic performance in Latin American populations, according to a newly published systematic review and meta-analysis.

Surgical intervention for severe osteoarthritis continues to be a critical decision point in orthopedics.

Liver transplant patients face a substantial risk of bone fractures despite following specialized care protocols, according to new findings.

In a breakthrough study that could reshape long-term treatment strategies for psoriatic arthritis (PsA), researchers have found that a small but significant proportion of patients can achieve and maintain remission without the continued use of disease-modifying antirheumatic drugs (DMARDs).

In a landmark systematic review and meta-analysis, researchers have shed new light on the optimal timing for mobilization following open reduction and internal fixation (ORIF) of hand fractures.

Healthcare professionals working with people with inflammatory arthritis (IA) report that emotional, economic and social barriers significantly impact patients’ ability to stay employed.

Rheumatoid arthritis (RA) has long been linked to increased cardiovascular disease risk, and new findings using speckle tracking strain ultrasonography reveal the extent of subclinical vascular damage in this patient population.

In a new analysis of U.S. postmenopausal women, researchers have uncovered a striking U-shaped relationship between reproductive timing and osteoarthritis (OA) risk, suggesting that the spacing between childbirths and maternal age at delivery could influence long-term joint health.

Improving communication between nurses is critical to patient safety and care quality, particularly in complex specialties like rheumatology and immunology.

Understanding referral patterns in rheumatic disease management is crucial to improving interdisciplinary care and patient outcomes.

In patients with rheumatoid arthritis (RA), understanding the risk of venous thromboembolism (VTE) is increasingly important as treatment strategies evolve.

Juvenile idiopathic arthritis (JIA), the most common chronic rheumatic disease in children, may carry underrecognized risks for endocrine dysfunction, according to a new study that highlights significant growth and hormonal disturbances in this vulnerable population.

Chronic insomnia, already known for its toll on mental and physical health, has now been linked to an increased risk of developing specific autoimmune diseases, according to a recent large-scale cohort study conducted in the United States.

In Japan, home to the world’s most rapidly aging society, managing rheumatoid arthritis (RA) in elderly patients has posed unique challenges for healthcare providers.

Multimorbidity, the presence of multiple co-existing health conditions, has emerged as a critical factor influencing survival and physical function in patients with systemic sclerosis (SSc), according to a large cohort study of 2,000 participants.

New research reveals that adults with rheumatoid arthritis (RA) are significantly more likely to develop sleep disorders, including insomnia, than those without the disease, a finding that raises important questions for rheumatologists and primary care providers.

New U.S. data analyzing 90-day outcomes after nonelective total hip arthroplasty (THA) for hip fracture reveals that male patients and those with pre-existing comorbidities face significantly higher risks of readmission and in-hospital mortality.

In a randomized trial, researchers evaluated two physical therapy approaches—high-intensity laser therapy (HILT) and short-wave diathermy (SWD), each combined with exercise, for treating patients with Stage 2–3 knee osteoarthritis.

In older adults with newly diagnosed late-onset rheumatoid arthritis (LORA), long-term glucocorticoid (GC) use remains persistent for a notable subset, according to a new analysis of national Medicare data spanning nearly a decade.

In patients with systemic sclerosis (SSc), the presence of calcinosis cutis, abnormal calcium deposits in the skin, may signal a deeper issue tied to osteoclastogenesis, the formation of bone-resorbing cells, according to a new study.

Healthcare professionals in the U.S. are closely watching progress in the diagnosis and management of IgG4-related periaortitis, periarteritis, and retroperitoneal fibrosis, a complex subset of IgG4-related disease (IgG4-RD) that mimics other conditions and defies simple diagnostic approaches.

A new prospective cohort study has found that the rate of skin thickening progression in patients with systemic sclerosis (SSc), measured using the modified Rodnan skin score (mRSS), is closely correlated with the early onset of serious cardiopulmonary complications, including interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH).

A new study examining the long-term effects of a specific carbohydrate diet (SCD) in children with juvenile idiopathic arthritis (JIA) suggests potential benefits, particularly for individuals seeking to avoid medication escalation.

AI is making significant strides in the diagnosis and outcome prediction of vasculitides, rare inflammatory disorders that can be challenging to identify due to their diverse clinical presentations.

Children with juvenile idiopathic arthritis (JIA) face more than just joint pain, emerging research reveals that the condition may significantly delay puberty.

Adipose-derived stem cells (ADSCs) may offer a groundbreaking new approach to treating systemic sclerosis (SSc), according to a recent study.

A recent analysis of the SENSCIS and SENSCIS-ON trials has demonstrated that nintedanib effectively slows the decline in forced vital capacity (FVC) among patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD).

A recent study conducted with the UK Medical Cannabis Registry evaluated the impact of cannabis-based medicinal products (CBMPs) on patients suffering from chronic pain due to hypermobility spectrum disorder (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS).

AI is emerging as a promising tool in the diagnosis and management of vasculitides, a group of rare inflammatory disorders that pose significant diagnostic challenges.

The psychometric properties of the Scleroderma Skin Questionnaire (SSQ), a novel patient-reported outcome (PRO) designed to assess skin disease in patients with systemic sclerosis (SSc), has been evaluated in a new study.

A recent long-term population study from Western Australia has revealed critical insights into the relationship between rheumatoid arthritis (RA) and cancer outcomes.

A recent analysis from the RESOLVE-1 trial has highlighted the potential of mycophenolate mofetil (MMF) in treating diffuse cutaneous systemic sclerosis (dcSSc), particularly in early-stage disease.

Inflammation is increasingly recognized as a pivotal factor in the development of atherosclerosis and its associated thrombotic complications.

Explore the efficacy and safety of first-line targeted synthetic DMARDs in rheumatoid arthritis patients with chronic kidney disease, highlighting potential risks like deep vein thrombosis.

Gastroesophageal (GE) symptoms, such as acid reflux and heartburn, are significantly associated with higher disease activity in patients with rheumatoid arthritis (RA), according to a new study.

For patients with rheumatoid arthritis (RA) with an inadequate response to Janus kinase inhibitors (JAKi), new research suggests that cycling to another JAKi may be more effective than switching to a biologic disease-modifying anti-rheumatic drug (bDMARD).

A recent study evaluated the advantages and limitations of various noninvasive imaging modalities in diagnosing cardiovascular disease (CVD) in patients with autoimmune rheumatic diseases (ARDs).

A recent cross-sectional study conducted at a quaternary hospital in Brazil has provided new insights into joint involvement in Sjögren’s disease (SjD), challenging its traditional classification as a non-erosive condition.

The potential of high-content imaging as a game-changer for precision medicine in rheumatoid arthritis (RA) has been highlighted in a new study.

A ketogenic diet (KD) may worsen osteoarthritis (OA) severity and increase pain sensitivity according to the results of a new study.

Risks of autoimmune conditions (ACs) in patients treated with immune checkpoint inhibitors (ICIs), a critical class of cancer immunotherapies, have been explored in a new epidemiological study.

A recent randomized clinical trial has demonstrated that incorporating healthy lifestyle care into chronic low back pain management can provide small but meaningful improvements in disability, weight loss, and quality of life.

A genetic link between air pollution exposure and the risk of developing autoimmune diseases such as rheumatoid arthritis (RA), lupus, and psoriasis, has been identified in a new study.

Frailty, a dynamic and clinically significant condition, is prevalent among patients with systemic sclerosis (SSc), according to a recently published study.

The way patients and clinicians prioritize different aspects of psoriatic arthritis (PsA) has been revealed in a new study that shed light on important disparities that could impact care quality and outcomes.

A diagnostic model has been developed for primary Sjögren’s disease (pSjD), utilizing salivary biomarkers, serum autoantibodies, and Schirmer’s test.

Achieving medication-free remission (MFR) is a critical milestone in the treatment of juvenile dermatomyositis (JDM), a rare inflammatory disease primarily affecting skin and muscles.

Botulinum toxin (BTX), widely known for its cosmetic and neurological applications, is emerging as a potential treatment for Raynaud’s phenomenon (RP), particularly when secondary to scleroderma.

Native Americans experience the highest premature mortality rates from rheumatoid arthritis (RA) in the United States, according to a comprehensive study analyzing national data from 1999 to 2020.

TNF inhibitors reduce fracture risk in axial spondyloarthritis, offering protection against complications from chronic inflammation.

A new study from Western Australia reveals that while patients with rheumatoid arthritis (RA) have a lower overall cancer incidence compared to the general population, they face higher risks for lung and hematological cancers.

A recent study conducted across five centers in Shelby County, Tennessee, reveals concerning disparities in the diagnosis and severity of axial spondyloarthritis (axSpA) in Black Americans.

A recent study exploring the impact of estrogen and progesterone analog supplementation on autoimmune conditions reveals a concerning association with several diseases.

Insights into predicting psoriatic arthritis (PsA) in juvenile idiopathic arthritis (JIA) patients, 18 years after their initial diagnosis, were shared in a recent study.

Regulatory T (Treg) cells are vital for immune system balance, preventing autoimmune diseases by suppressing inflammation.

According to a new study, achieving sustained drug-free remission (SDFR) in giant cell arteritis (GCA) is possible for a significant subset of patients, with low relapse rates once remission is reached.

Females who experience infertility but do not use fertility treatment may be at an increased risk for developing systemic autoimmune rheumatic disease (SARD) after childbirth, according to a new population-based cohort study.

Genicular artery embolization (GAE), a minimally invasive procedure, offers promising relief for patients with knee osteoarthritis, potentially delaying or eliminating the need for knee replacement surgery, according to new findings presented at the Radiological Society of North America (RSNA) annual meeting.

Investigation into colchicine’s potential as a treatment for knee osteoarthritis (OA) found no significant improvement in pain or function in a recent study.

Women with psoriatic arthritis (PsA) experience longer delays in diagnosis, more intense symptoms, and distinct challenges with treatment compared to men, according to findings presented by Lihi Eder at ACR Convergence 2024.

Medical cannabis, a widely debated topic, took center stage at the ACR Convergence 2024, where researchers explored its role in managing chronic pain related to rheumatic diseases.

Sodium channels in cartilage cells may hold the key to treating osteoarthritis (OA), a new study presented at ACR Convergence 2024 unveiled.

The way couples manage stress together profoundly impacts outcomes for patients with rheumatoid arthritis (RA), according to a new study.

The treatment landscape for juvenile idiopathic arthritis (JIA) has shifted significantly over the past two decades, according to a new study analyzing DMARD (disease-modifying antirheumatic drug) utilization among commercially insured children in the United States from 2001 to 2022.

Inebilizumab, a CD19+ B-cell depleting therapy, can reduce flares and promote remission in patients with IgG4-related disease (IgG4-RD) according to the results of a new Phase III clinical trial.

Novel molecular regulators of rheumatoid arthritis (RA) inflammation were presented as part of a plenary abstract session at the ACR Convergence 2024 in Washington, D.C.

Data from the DAHLIAS Phase II was presented at ACR Convergence 2024 in Washington, D.C., as part of an abstract plenary session, sharing efficacy and safety of nipocalimab in treating primary Sjögren’s disease.

Evidence supporting a novel therapeutic target for systemic lupus erythematosus (SLE), the E3 ubiquitin ligase “E3-X”, was presented at ACR Convergence 2024 in Washington, D.C.

Researchers unveiled a groundbreaking study shedding light on the complex molecular interplay driving fibrosis in diffuse systemic sclerosis (dcSSc) at ACR 2024 in Washington, D.C., USA.

New research into how antisynthetase autoantibodies disrupt critical enzymatic functions in muscle cells was presented as part of a plenary abstract session at ACR Convergence 2024 in Washington, D.C.

Participation in the Rheumatology Informatics System for Effectiveness (RISE), an electronic heath record (EHR)-enabled registry designed by the American College of Rheumatology (ACR), significantly improves clinical care metrics, according to a study presented at ACR Convergence 2024.

A Phase III clinical trial presented at ACR Convergence 2024 revealed that upadacitinib (UPA), combined with a 26-week glucocorticoid (GC) improved disease control and reduced steroid exposure compared to a placebo (PBO) regimen in patients with giant cell arteritis (GCA).

Presented at the ACR Convergence 2024, new research highlighted how changing global recruitment patterns influence placebo response rates in clinical trials for psoriatic arthritis (PsA).

In a groundbreaking study, once-weekly semaglutide injections were shown to significantly reduce both knee osteoarthritis pain and body weight in adults with obesity, offering promising new relief for patients with limited treatment options.

Recent findings have underscored the role of traumatic stress as a potent trigger for autoimmune rheumatic diseases (ARDs), emphasizing a feedback loop that perpetuates these conditions.

Systemic lupus erythematosus impacts placental health, particularly in pregnancies resulting in small for gestational age infants.

Hot and cold outdoor temperatures significantly worsen Raynaud’s phenomenon in patients with systemic sclerosis, according to new research.

Adoption of cutting-edge imaging technologies and innovative use of existing methods may revolutionize the diagnosis and treatment of inflammatory arthritis.

New study found that increasing secukinumab dosage to 300 mg provides no significant benefit for ankylosing spondylitis patients who did not respond to 150 mg.

The effects of radiotherapy on patients with systemic sclerosis (SSc) who develop cancer is a subject of growing concern due to the potential exacerbation of SSc symptoms and the risks of radiotherapy-related toxicity.

Patient participation in shared decision-making is said to be beneficial when it comes to disease management, yet, few studies have researched this in the management of systemic lupus erythematosus.

A new study brought to light significant risks associated with infections in children and adolescents with childhood-onset systemic lupus erythematosus.

A recent study has identified an association between neighbourhood deprivation and the severity of discoid lupus erythematosus in adult patients.

Rheumatoid arthritis nearly doubles the risk of heart failure, driven by inflammation-linked HFpEF, highlighting the need for proactive cardiovascular care.