Allergy & Immunology

Five consecutive daily injections of antigen-specific tVLPs protected mice from allergic symptoms and anaphylactic shock following allergen exposure.

Mean urinary concentrations of two pseudo leukotrienes were elevated four- to five-fold in individuals with severe asthma compared with controls (P=0.004 and P=0.0015).

Researchers identified a distinct population of tissue-resident memory T (TRM) cells expressing IL-17A and/or IL-17F that were largely absent from healthy skin.

Exclusive breastfeeding for at least four months was associated with lower overall odds of asthma up to age 24 years (odds ratio: 0.75; 95% CI: 0.64–0.87).

Londamocitinib produced approximately 50% reductions in fractional exhaled nitric oxide at the 1.4 mg and 3 mg doses.

Importantly, this microbiota–metabolite signature was inversely associated with the development of food allergen-specific IgE up to 5 years of age and with atopic dermatitis at 2 years.

ALA-DAG oil improved skin hydration and reduced allergic symptoms in adults with mild skin discomfort.

After 1 year, 13 of 17 patients in the 30 mg group tolerated at least 443 mg peanut protein, compared with none in the avoidance group. Similar improvements were observed in the 300 mg group.