Allergy & Immunology

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Deep Learning Reveals Novel Asthma Risk Variants

April 2026

Polygenic risk score models derived from variants prioritised by the deep learning framework demonstrated improved predictive performance compared with those based on traditional GWAS approaches.

Deep Learning Reveals Novel Asthma Risk Variants

Polygenic risk score models derived from variants prioritised by the deep learning framework demonstrated improved predictive performance compared with those based on traditional GWAS approaches.

Artificial Intelligence Improves Seasonal Allergic Rhinitis Diagnosis

Artificial Intelligence Improves Seasonal Allergic Rhinitis Diagnosis

In a direct comparison, the AI models outperformed 24 clinicians when diagnosing a subset of patients.

Breakthrough Nanoparticle Therapy for Allergic Rhinitis

In a mouse model of allergic rhinitis, even a very low dose (0.5 ng) of bryo-1 delivered via anionic LNPs increased antigen-specific IgA levels in salivary secretions.

Oral Immunotherapy Cost-Effective for Peanut Allergy in Children

Oral Immunotherapy Cost-Effective for Peanut Allergy in Children

While treatment costs were higher – A$3956 for PPOIT and A$3582 for OIT versus A$249 for no treatment – these were offset by improved clinical outcomes.

Atopic Dermatitis Linked to S1P Immune Signalling

Mechanistic studies revealed a reciprocal relationship between receptors: S1PR1 enhanced IL-13 and IL-9 production, whereas S1PR5 suppressed these cytokines.

Gut Microbiota Disruption Identified in FPIES Children

Gut Microbiota Disruption Identified in FPIES Children

Notably, children with FPIES showed reduced abundance of Bifidobacterium, a genus widely considered beneficial for gut and immune health.

Key Priorities for Next-Generation Adrenaline Auto-Injectors

Among the most highly prioritised features were a longer product shelf life and improved storage conditions, both receiving a median importance score of 9.

New Proteins Identified as Drivers of Oral Tolerance

New Proteins Identified as Drivers of Oral Tolerance

Functional experiments showed that α-zein–specific Treg cells suppressed naïve T cell proliferation when exposed to the antigen, confirming their role in maintaining oral tolerance.

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