Allergy & Immunology

After 1 year, 13 of 17 patients in the 30 mg group tolerated at least 443 mg peanut protein, compared with none in the avoidance group. Similar improvements were observed in the 300 mg group.

Autoclaving peanuts significantly reduces IgE binding and improves tolerability in peanut-allergic individuals, offering promise for safer immunotherapy approaches.

The basophil activation test may help identify children at risk of severe allergic reactions to cow’s milk, improving safety during oral food challenges.

A Canadian real-world study reveals high oral corticosteroid exposure in patients with severe chronic rhinosinusitis with nasal polyps prior to biologic therapy.

International panel of anaphylaxis experts develops guidance for non-medical personnel to correctly identify patients with acute allergic reactions that require epinephrine administration.  

High airway TSLP levels identify a subset of severe asthma patients with type 2 inflammation, mucus plugging, and airway remodelling despite corticosteroid treatment.

Interview study shows injectable on-demand treatments for hereditary angioedema may delay care and negatively impact quality of life, highlighting demand for oral options.

A clinical trial shows immune-targeted therapy tailored to sepsis subtypes improves organ function by day 9, offering a new approach to treatment.

Very low-dose multi-nut oral immunotherapy significantly increased tolerance in children with multiple nut allergies, with a favourable safety profile and no epinephrine use.

A new ANAcare pathway offers clinicians practical, harmonised steps to apply the latest guidelines for diagnosing IgE-mediated food allergy.

A new US Drug Allergy Registry report outlines standardised paediatric antibiotic allergy testing protocols to curb unnecessary labels and harmonise research.

A new BSI-CIPN report warns that UK clinical immunology and allergy services are critically understaffed, calling for urgent national workforce planning and investment.

A rare case of ABPA presenting as pyopneumothorax highlights the need for early recognition of pleural complications in asthmatic patients.

Blood proteomics uncovers systemic immune changes across inflammatory skin conditions.

Depression and anxiety increase asthma attack risk in adults, highlighting need for targeted care in those with comorbid mental health disorders.

A French national study has identified eight emerging food allergens frequently causing anaphylaxis but not included in EU labelling rules.

A new milk allergy therapy protocol lowers the severity of gastrointestinal reactions during OIT, improving safety for patients.

A 10-year study shows allergen immunotherapy provides lasting symptom relief in local allergic rhinitis and reduces the risk of asthma and new sensitizations.

A newly reported fatal case of delayed anaphylaxis following beef consumption highlights the growing impact of alpha-gal syndrome.

Transepidermal water loss monitoring lowered anaphylaxis rates and reaction severity during peanut oral food challenges, offering a potential tool to improve diagnostic safety.

While further large-scale trials are needed, this precision-based treatment represents a promising advance in managing atopic dermatitis.

By integrating PAE into standard hospital practice, this initiative aims to reduce inaccurate allergy labels with the aim of lowering antibiotic resistance.

A large U.S. study finds people with seborrhoeic dermatitis are more likely to develop other barrier-related diseases, supporting the epithelial barrier theory.

Research consistently shows that epinephrine is underused, with many patients instead receiving antihistamines or steroids despite these offering only supportive relief.

A multicentre, randomised, controlled trial evaluated the efficacy and safety of integrating nasal saline irrigation with Aze-Flu nasal spray.

The relationship between allergic rhinitis and optic neuritis appears to involve shared inflammatory pathways.

Discover a study on drug provocation tests in mastocytosis, revealing how they safely identify tolerable medications and reduce the risk of severe hypersensitivity reactions.

A recent study examined 36 months of peanut sublingual immunotherapy in children aged 1–4 years, assessing both desensitisation and remission outcomes.

Patients with elevated TSLP may represent a unique target population for specific therapies, including biologics that modulate Type 2 inflammation.

The JECS cohort followed more than 88,000 newborns across Japan, assessing allergic conditions from birth to age four.

These declines were observed regardless of atopic dermatitis diagnosis, indicating that early food introduction benefits both high-risk and general populations.

This paradoxical effect appears to be context-dependent, influenced by factors such as infection, allergen exposure, and systemic stress.

The study found that urinary øLT levels were significantly elevated, four- to five-fold higher, in patients with severe asthma compared to healthy controls.

Enhancing PPIE in allergic disease research offers tangible benefits, from improving patient outcomes to ensuring studies align with real-world needs.

The review revealed that patients consistently prioritise rapid symptom relief, preferably within two weeks, alongside long-term control of hives, itching, and swelling.

The study found that pectin treatment improved Pru p 3 tolerance in over half of participants, with 30% achieving full tolerance to the equivalent of a whole peach.

A study reveals that vitamin C supplementation during pregnancy in smokers influences asthma-related DNA methylation in children. This epigenetic change supports better lung health at 5 years.

Discover a study showing how baked milk intake accelerates cow’s milk allergy resolution, boosting safety and tolerance in young children.

The study’s objective was to assess the safety of a two-step direct challenge (DC) to amoxicillin, crucially performed without preceding skin testing.

A major new study has provided evidence that treatment for childhood asthma could be significantly improved by replacing traditional salbutamol relievers with budesonide–formoterol.

Food allergies are now considered the “second wave” of the allergy epidemic, following asthma, and they disproportionately affect infants and young children.

Lateral flow Enhanced by Optical imaging combines the proven lateral flow assay platform with advanced smartphone-based image analysis.

Findings revealed that 17 allergens, already part of the adult EBS, produced positive reactions in at least 1% of children.

Large-scale surveys, such as those conducted by the University of Chicago, align with these findings, reporting crustacean allergy prevalence of around 1.2%.

Previous research has shown that blueberry intake in adults increases beneficial Bifidobacterium species, enhances gut barrier integrity, and reduces inflammation.

Discover a study exploring how AI can transform allergy and immunology, highlighting challenges, opportunities, and a roadmap for clinical impact.

Discover a study exploring how a traditional Chinese herbal formula significantly reduced symptoms of seasonal allergic rhinitis with minimal side effects.

Learn how omalizumab shows high response rates and low side effects in children with chronic spontaneous urticaria.