Allergy & Immunology

A major meta-analysis of 2.8 million children identifies genetic, clinical, and early-life exposures linked to childhood food allergy risk and prevention strategies.

A study of 1,368 participants shows allergic rhinitis alters COVID 19 symptoms, with sublingual immunotherapy increasing respiratory risk but lowering fever incidence.

Children born to older mothers showed lower risks of food allergy, wheezing, and allergen sensitisation in early childhood, suggesting advanced maternal age may have a protective role.

Five consecutive daily injections of antigen-specific tVLPs protected mice from allergic symptoms and anaphylactic shock following allergen exposure.

Mean urinary concentrations of two pseudo leukotrienes were elevated four- to five-fold in individuals with severe asthma compared with controls (P=0.004 and P=0.0015).

Researchers identified a distinct population of tissue-resident memory T (TRM) cells expressing IL-17A and/or IL-17F that were largely absent from healthy skin.

Exclusive breastfeeding for at least four months was associated with lower overall odds of asthma up to age 24 years (odds ratio: 0.75; 95% CI: 0.64–0.87).

Londamocitinib produced approximately 50% reductions in fractional exhaled nitric oxide at the 1.4 mg and 3 mg doses.