Hematology

TP53 and PPM1D are key regulators of DNA damage response and repair, and somatic mutations in these genes often…

Sickle cell disease (SCD) is a genetic disorder characterised by chronic inflammation, vaso-occlusion, and endothelial…

Patients (pts) with acute lymphoblastic leukaemia (ALL) in difficult first complete remission (CR) or in second CR, and…

In 40–70% of patients referred to a haematologist for the evaluation of an increased bleeding tendency, no diagnosis can…

Chronic myelomonocytic leukaemia (CMML) is a rare cancer orchestrated by granulocyte-macrophage colony-stimulating factor (GM-CSF)…

Understanding how loss of function mutation of TET2 in haematopoietic stem cells (HSC) changes their response to stress is crucial to…

The KMT2A-MLLT3 (also known as MLL-AF9) fusion is associated with acute lymphoid leukaemia (ALL), acute myeloid leukaemia (AML), and mixed…

The historical International Prognostic Score (IPS-7), which was developed with patient data from the 1980s, and the more recent IPS-3…