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hematology 8.1 featured image
2 Mins
30 Jul 2020

Identification of HIF2α as a Novel Determinant of Acute Myeloid Leukaemia Block of Differentiation Poses its Inhibition as a Potential Therapeutic Opportunity for Acute Myeloid Leukaemia Patients

Signalling via hypoxia inducible factors (HIF)1α and HIF2α is importantly implicated in cancer,1 although it has been predominantly studied in solid…
hematology 8.1 featured image
1 Mins
30 Jul 2020

Comparison of Decitabine with Venetoclax versus Intensive Chemotherapy Using Propensity Score Matching and Treatment-related Mortality Risk Scoring

Acute myeloid leukaemia (AML) usually presents in older patients over the age of 65 years.1 A large proportion of such patients are frail or have…
EMJ Hematology US 1.1 2020
2 Mins
24 Jan 2020

Fli-1 Transcriptionally Integrates Microenvironmental Cues Sensing by Self-Renewing Haematopoietic Stem and Progenitor Cells

During adulthood and embryogenesis, fate decisions of haematopoietic stem and progenitor cells (HSPC), such as specification, self-renewal, and…
EMJ Hematology US 1.1 2020
2 Mins
24 Jan 2020

Novel CD33 Antibodies Reveal CD33 Splicing Polymorphism Variant Localisation and Therapeutic Implications

Acute myeloid leukaemia (AML) is a heterogeneous haematologic malignancy characterised by dysfunctional proliferation and differentiation of myeloid progenitor cells.
EMJ Hematology US 1.1 2020
2 Mins
24 Jan 2020

Safety and Efficacy of 1,020 mg Total Dose Infusion of Ferumoxytol in a Veterans Health System

Ferumoxytol is an intravenous (IV) formulation of iron that can be infused quickly, making it a convenient choice.
EMJ Hematology US 1.1 2020
1 Mins
24 Jan 2020

Assessment of Mortality and its Associated Risk Factors in Patients with Transfusion-Dependent Thalassaemia in India

India is home to approximately 100,000 people living with transfusion-dependent severe thalassaemia,1 and yet very little data on survival are available…
EMJ Hematology US 1.1 2020
2 Mins
24 Jan 2020

Lactate Release by Inflammatory Bone Marrow Neutrophils Induces their Mobilisation via Endothelial GPR81 Signalling

Innate immune neutrophils provide the first line of host defence against bacterial infections.
1 Mins
1 Aug 2019

Tagraxofusp is a Novel Targeted Therapy Directed to CD123

Blastic plasmocytoid dendritic cell neoplasm (BPDCN), a rare, highly aggressive haematologic malignancy, often with cutaneous and other extramedullary…
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