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8 Aug 2017

Front-Line Vascular Access Devices in Peripherally Inserted Acute Leukaemias: Central Catheter Versus Traditional Central Venous Catheter: A Phase IV Randomised Trial

For high-risk haematological patients, in particular those with acute leukaemia, there is limited information on the use of peripherally inserted…
1 Mins
8 Aug 2017

Oral Rigosertib Combined With Azacitidine in Patients with Myelodysplastic Syndromes and Acute Myeloid Leukaemia: Effects in Treatment Naïve and Relapsed/ Refractory Patients

Azacitidine is the standard of care for higher risk myelodysplastic syndromes (MDS); however, only approximately 50% of patients respond, and those…
2 Mins
8 Aug 2017

Minimal Residual Disease Monitoring by Digital PCR for JAK2V617F Detection in Patients with Myelofibrosis or Acute Myeloid Leukaemia Secondary to Myelofibrosis after Allogeneic Stem Cell Transplantation

Myelofibrosis (MF) is one of the BCR-ABL1-negative chronic myeloproliferative neoplasms (MPNs), characterised by clonal expansion of abnormal…
2 Mins
28 Jul 2016

Evidence-Based Transfusion Medicine for Coagulopathy of Chronic Liver Disease

Patients with chronic liver disease variably exhibit abnormalities of coagulation related to decreased synthesis of coagulation proteins. This results in…
2 Mins
28 Jul 2016

Management of Superficial Vein Thrombosis

Superficial vein thrombosis (SVT), indicating thrombosis of the superficial vein system, is less well-studied than deep vein thrombosis (DVT) because it…
2 Mins
28 Jul 2016

GBT440, a Novel Sickle Haemoglobin Polymerisation Inhibitor, Increases Haemoglobin Oxygen Affinity and Results in a Rapid Improvement in Haemolysis and Anaemia

GBT440 is a novel, small molecule haemoglobin oxygen affinity modifier. In vitro data has shown that by increasing sickle haemoglobin (HbS) oxygen…
2 Mins
28 Jul 2016

Role of the Calreticulin Gene and Its Deregulation in Myeloproliferative Neoplasms

Polycythaemia vera (PV), essential thrombocythaemia (ET), and primary myelofibrosis (PMF) are the three classical Philadelphia chromosome-negative…
2 Mins
28 Jul 2016

Family-Directed Cord Blood Banking for Sickle Cell Disease: A 20-Year Experience on Behalf of Eurocord-Monacord and the International Sickle Cell Disease Observatory

Cord blood transplantation (CBT) from a related family member is an effective therapy for patients with sickle cell disease (SCD) resulting in…
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