Hematology

von Willebrand disease (VWD) is considered the most common inherited bleeding disorder, even surpassing haemophilia A. Nevertheless, VWD…

Synchronous twin malignancies, defined as the simultaneous occurrence of two distinct primary cancers in the same patient, represent a…

Topiramate is a well-known medication used for migraine and epilepsy. Bleeding is a rare and less documented side-effect of this treatment…

This year, the EHA Congress provided us with long-term follow-up of some very interesting study, including the GAIA/CLL13 trial…

In the beginning, when I was very young, I was more interested in acute leukaemia and the suffering of young people. When I got to…

Joshua Richter – Associate Professor, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA. What initially…

Latest data from the global ALLELE study confirms the benefits of tabelecleucel cell therapy for transplant recipients who go on to develop a rare but often fatal blood cancer.

Haemophilia A (HA), defined by factor VIII (FVIII) levels ≤40 IU/dL, is a chronic condition with consequences beyond bleeding…

The limitations of currently available therapies for immune thrombocytopenia (ITP) mean that long-term responses are difficult to maintain…

AIHA is an acquired, heterogeneous group of rare diseases with a prevalence of 17 per 100,000.1 This group includes wAIHA…

Haemophilia A is an inherited deficiency in coagulation FVIII. Based on their residual FVIII activity levels, PwHA are considered to have…

Myelodysplastic syndromes are a group of disorders that affect the bone marrow, subsequently affecting the growth and relative…

Diffuse large B cell lymphoma (DLBCL) is the most common histological subtype of non-Hodgkin’s lymphoma. However, splenic DLBCL is a…

Infertility post stem cell allograft is a common event, with the frequency uncertain because the wish for pregnancy is not commonly…

One-fourth of the global population is anaemic, and as the population is gradually increasing day by day, so does the number of anaemia…

May-Thurner syndrome (MTS) is defined as symptomatic compression of the left common iliac vein by the overlying right common iliac artery…

Despite what Mohty described as “progressive advances in the field” over recent years, significant unmet needs remain in the front-line…

When I was a medical student in the small university city of Cork, in Ireland, there was one female consultant, and she was a haematologist…

I think the beginning was when I graduated in the 1960s; my thesis was on red cell enzymes within haematology, but it had nothing to do…

Multiple myeloma (MM) is a disease characterised by the clonal expansion of malignant plasma cells in the marrow, leading to anaemia…

Sickle cell disease (SCD) is a genetic condition caused by mutations in the haemoglobin (Hb) gene, resulting in various complications. One…

Since its earliest days, the effective use of anticoagulation for prevention of stroke and other thromboembolic events has been limited by…

Wolfgang Miesbach, Professor of Medicine, Frankfurt University Hospital, Germany; Congress President, European Association for Haemophilia…

Amyloidosis results from a misconfiguration of normal protein into β-plated linear sheets, leading to the formation and deposition of…

Pyruvate kinase (PK) deficiency is a hereditary haemolytic anaemia caused by mutations in the PKLR gene encoding PK, which is critical…

This continuing medical education-accredited symposium, held at the 2023 International Society for Thrombosis and Haemostasis (ISTH)…

The thalassaemias are a heterogeneous group of inherited chronic blood disorders associated with impaired haemoglobin (Hb) synthesis…

DLBCL accounts for approximately 30% of non-Hodgkin’s lymphomas diagnosed each year. Initially, DLBCL is generally treated…

The overarching message from the symposium was that diagnosis of SM-AHN is challenging, and SM is often missed in patients with a myeloid…

This article summarises the occurrence of very unusual and rare steroid-related toxicity. It is a cautionary tale of modern medicine where the treatment-related adverse events are more atrocious than the primary disease.

Janis Abkowitz | Head, Division of Hematology, University of Washington, Seattle, USA; Adjunct Professor of Genome Sciences, University of…

Cynthia Dunbar – Secretary, American Society of Hematology (ASH); Chief, Translational Stem Cell Biology Branch, and Head, Molecular…

Gene therapy for haemophilia A and B was discussed during several sessions at the 64th American Society of Hematology (ASH) Annual Meeting, held 10th–13th December 2022.

This year’s European Organisation for Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Tumours Group (CLTG) Annual Meeting was held in Madrid, Spain. Presentations covered a broad range of topics in the field of cutaneous lymphomas, from molecular mechanisms, through diagnostics and prediction of prognosis, to skin-directed and targeted therapies, combination therapies, and patient-reported outcomes.

Kakkar opened the symposium by highlighting the burden of thrombotic disease in patients with cancer with a discussion of data from the Global Anticoagulant Registry in the FIELD – Venous Thromboembolism (GARFIELD-VTE) registry.

At the International Society on Thrombosis and Haemostasis (ISTH) 2022 Congress, held 9th–13th July, multiple oral and poster presentations were dedicated to gene therapy as a treatment for haemophilia A or B.

Three posters presented at the European Hematology Association (EHA) 2022 Hybrid Congress focused on the role of mitapivat in the…

Von Willebrand disease (VWD) was first described in 1926 by Erik von Willebrand when he cared for a family member…

My selection for this issue is the article ‘Social Impact and Quality of Life of Patients with β-Thalassemia: A Systematic Review’ by Greco and Marino. Quality of life is becoming more and more important in the evaluation of clinical trials, and also by regulatory authorities, particularly in chronic diseases (which can be seen by the U.S. Food and Drug Administration’s [FDA] recent position on luspatercept). Therefore, understanding its meaning and limitations is very important.

The following highlights focus on several insightful and innovative abstracts at the European Hematology Association (EHA) 2022 hybrid…

The hypomethylating agents (HMA), azacitidine and decitabine, are currently regarded as the standard of care for patients with…

Monogenic diseases such as haemophilia A and B are inherited conditions arising from mutations in a single gene. One defective gene leads…

Higher-risk MDS is a collective term based on the Revised International Prognostic Scoring System (IPSS-R) that encompasses…

Multiple myeloma (MM) is a B cell malignancy characterised by abnormal proliferation of plasma cells that expand in the bone marrow…

In the past decade, therapies that are more effective and less toxic have transformed the treatment landscape for patients with MM…

The following highlights focus on several insightful and innovative abstracts at the European Hematology Association (EHA) 2022 hybrid…

CTCL is a rare type of non-Hodgkin lymphoma, primarily presenting in the skin but with extracutaneous involvement in some patients. Around…

Recent efforts to incorporate genome editing into CAR T cell therapy offers novel opportunities for treatment of haematologic malignancies…

Ajay Kakkar opened this virtual meeting by discussing the history of the treatment and prevention of thrombosis…

Rachel Kesse-Adu highlighted that the hallmark of sickle cell disease (SCD) is painful vaso-occlusive crises (VOCs). These not only cause…

In recent years, there has been an increasing appreciation of the role that patient characteristics such as age, gender…

Although approximately 60% of patients with diffuse large B-cell lymphoma (DLBCL) can be cured, the remaining 40% have relapsed or refractory disease (R/R DLBCL). Substantial unmet need remains for effective, safe therapies for these patients. Novel targeted approaches to the treatment of R/R DLBCL include CD19-directed antibodies, antibody–drug conjugates, bispecific monoclonal antibodies, and anti-CD-19 chimeric antigen receptor (CAR) T-cell therapies.

The COVID-19 outbreak, first identified in the Wuhan district of China in December 2019, was declared a pandemic by the World Health…

At the 14th Annual Congress of the European Association for Haemophilia and Allied Disorders (EAHAD), held virtually, data on the efficacy…

Mycosis fungoides (MF) and Sézary syndrome (SS), two of the most-studied types of cutaneous T-cell lymphoma (CTCL), account for approximately 60% and 10% of CTCL cases, respectively.

We are talking about 35 years ago, and some of what drew me to the practice is still true today. There were two major aspects of cancer…

von Willebrand factor (VWF) is a large, adhesive, multimeric protein involved in haemostasis. The larger the size (or number of VWF multimers), the greater the functionality of the protein.

Multiple myeloma is a haematological malignancy predominantly affecting older people and has a median age of onset of 70 years.

β-thalassaemias are a clinically heterogenous group of inherited disorders caused by >200 described mutations in the β-globin gene, leading to a decreased or absent production of the β-globin chain.

Polycythaemia vera (PV) is a condition characterised by an increasing number of the red blood cells in the blood.

Eduard Glanzmann first reported Glanzmann thrombasthenia (GT) in 1918 after he identified a functional abnormality of platelets with defective clot retraction.

Mutations in FLT3 are the most common genetic alteration in AML. Patients with a FLT3 internal tandem duplication (ITD) mutation subtype have poor prognosis, especially when there is a high allelic burden.

Multiple myeloma is a malignant neoplasm arising from clonal proliferation of plasma cells in the bone marrow…

Acute myeloid leukaemia (AML) is a life-threatening, multifactorial haematological neoplasm characterised by the accumulation of transformed immature myeloid progenitors…

This symposium took place virtually at the European School of Haematology (ESH) 7th Translational Research e-Conference: Myelodysplastic Syndromes (MDS)…

Thrombocytopenia is generally defined as a platelet count below the lower normal limit, <150×109/L, although many suggest that a cut-off value…

TIM-3 was first discovered in Prof Kuchroo’s laboratory in 2002. This lecture reviewed the history of the discovery of TIM-3, including…

As the second most common haematological malignancy, multiple myeloma (MM), a plasma cell disorder, continues to affect a significant portion of patients with increasing incidence over the past 25 years…

Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma and the most frequent non-Hodgkin lymphoma (NHL) in adults, accounting for 30–40%…

Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) is a positive-sense, single-stranded RNA virus that belongs to the coronavirus family, and it is the seventh in that family known to infect humans…

Paroxysmal nocturnal haemoglobinuria (PNH) is a rare disease of nonmalignant clonal haematopoietic stem cells with an estimated prevalence of 1–16 cases per million, which may be underestimated because of undiagnosed patients…

Although VOC are the hallmark of SCD, a lack of VOC events does not prevent chronic multi-organ damage. Patients with sickle cell anaemia (SCA)…

Ponatinib is indicated for the treatment of adults with chronic myeloid leukaemia (CML) who are resistant to dasatinib or nilotinib, are intolerant…

Anaemia is characterised by a decrease in the total amount of red blood cells (RBC) and haemoglobin (Hb) levels, reducing the volume of oxygen transported through the blood…

The American Society of Hematology (ASH) guidelines and the International Consensus Report (ICR) recommendations were first published in 2010 and 2011…

This symposium focussed on the recognition of, and treatment options for, high-risk AML. Prof Cluzeau considered universal or targeted treatment…

Isocitrate dehydrogenase 1 (IDH1) is a metabolic enzyme which catalyses the oxidative decarboxylation of isocitrate to α-ketoglutarate…

Venetoclax is a potent, selective, oral inhibitor of B-cell lymphoma-2. It is approved in the USA in combination with azacitidine, decitabine…

Haematological disorders are predominant in the tropical and subtropical countries where major problems of sickle-cell disease (SCD) and thalassaemias…

The initial management of deep vein thrombosis is starting to happen in general practice.

Many cases of pneumonia clustered in the city of Wuhan, China, were reported in December 2019, and source tracing has showed Huanan Seafood Market, Wuhan, China, as the origin.

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disorder resulting from autoantibodies produced by B-cell derived plasma cells.

Osteopetrosis (OP) is a rare genetically metabolic bone disorder caused by severe impairment of osteoclast-mediated bone resorption.

Haemophagocytic lymphohistiocytosis (HLH) is a rare but potentially aggressive and life-threatening syndrome of overactive histiocytes and lymphocytes…

This review centres on the impact next-generation sequencing (NGS) can have on the current management of haemato-oncological diseases…

The Kite, a Gilead company, symposium “Beyond Clinical Trials in B-Cell Malignancies: What Real-World Experience Tells Us” took place as part of the 24th…

The Kite, a Gilead Company, symposium “CAR-T: From bed to bench and back again” took place during the 2019 meeting of the International Conference…

Prof Sehn opened the symposium with an overview of diffuse large B-cell lymphoma (DLBCL) focussing on key milestones in treatment developments…

The first case focussed on a 56-year-old female economist, who presented with abdominal discomfort that led to a CT scan evaluation where lymph node…

Acute chest syndrome (ACS) is an acute inflammatory lung injury that usually follows the vaso-occlusive crisis (VOC) seen in sickle cell disease (SCD)…

Myelodysplastic syndromes (mds) are a heterogeneous group of disorders defined by ineffective haematopoiesis and clonal instability with risk of…

In low-grade B-cell lymphomas, Reed Sternberg (RS)-like cells can be seen in follicular lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, and marginal zone lymphoma.

Pernicious anaemia (PA) is an autoimmune disease of multifactorial aetiology involving environmental and immunological factors. It is the most common cause of cobalamin deficiency anaemia worldwide.

Acute vaso-occlusive crisis and haemolysis characterise sickle cell disease. Rarely observed, ‘girdle syndrome’ is a situation in which vaso-occlusion…

Treatment decisions in chronic myeloid leukaemia (CML) are complex and require the evaluation of many factors at each stage of therapy…

Biologic drugs are transforming treatment of other hard-to-treat diseases beyond cancer, including multiple sclerosis, heart disease, asthma, and…

Treatment of MM requires a multifaceted approach using a combination of therapies targeting the several pathophysiological pathways involved in the…

Cord blood can be collected and stored from the placenta and umbilical cord following the birth of a new-born. It is replete with haematopoietic stem…

Thalassaemia is a hereditary cause of hypochromic microcytic anaemia resulting from defects in haemoglobin (Hb) production…

Specifically, this study examines the use of abdominal imaging, via an ultrasound or CT scan, to identify the aetiology of haematologic abnormalities…

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder that lessens the production of platelets. Despite treatments being available for ITP…

Dasatinib is a potent and efficacious second-generation oral tyrosine kinase inhibitor, frequently used for imatinib-resistant or intolerant BCR-ABL+…

Currently, there is no evidence-based consensus for the management of CML in pregnancy; therefore, clinical observations have become very important…

Even though there are recent sophisticated biomarkers to diagnose sepsis, it is still challenging to curtail sepsis mortality by timely intervention…

Prof Salles provided an update on the ongoing first-line follicular lymphoma (FL) studies, demonstrating how analysis of the GALLIUM study data regarding…

Immunotherapy has revolutionised the treatment of haematologic malignancies. Patients with relapsed/refractory non-Hodgkin’s lymphoma have poor response…

Acute myeloid leukaemia (AML) is a disease with a very poor outcome and remains an area of significant unmet need, necessitating novel therapeutic…

Epstein–Barr virus (EBV) is one of the most important viral causes for the development of tumours. The global geographical epidemiology of EBV shows…

Although idiopathic aplastic anaemia (AA), myelodysplastic syndrome (MDS), and paroxysmal nocturnal haemoglobinuria (PNH) are all associated with…

The meeting was arranged as a series of conversations between experts, following a question and answer format with two speakers in each presentation…

The introduction of tyrosine kinase inhibitors (TKI) has dramatically improved the prognosis of chronic myeloid leukaemia (CML) patients and, therefore…

Although hypomethylating agents (HMA) have revolutionised the treatment of myelodysplastic syndromes (MDS), a significant proportion of patients either…

The humanised anti-CD20 antibody (Ab) rituximab (RTX) has significantly improved the prognosis of B cell non-Hodgkin’s lymphomas (BNHL). However, major…

Mycosis fungoides is the most common variant of cutaneous T cell lymphoma and frequently presents as early-stage disease with skin patches and plaques with an indolent course, but patients experience significant morbidity from itch and disfigurement.

Anaemia is the most widespread of the haematological disorders, affecting about one-third of the global population. Despite decades of public health…

Multiple myeloma is increasingly being recognised as more than one disease, characterised by marked cytogenetic, molecular, and proliferative heterogeneity.

β-thalassaemias are inherited blood disorders caused by a defect in the production of β-globin, giving rise to variable phenotypes.

Myelofibrosis (MF), either primary or secondary to polycythaemia vera or essential thrombocythaemia, is the most symptomatic and has the worst prognosis…

Hypereosinophilic syndromes are a group of disorders characterised by significant eosinophilia and organ damage.

Patients with refractory/relapsed (R/R) non-Hodgkin lymphoma (NHL) make up a very heterogeneous population with a poor life expectancy.

The objective of the symposium was to provide an overview of the current treatment landscape in terms of later-line therapy in metastatic CRC (mCRC) and to discuss the evidence for the various options available.

The main objectives of the symposium were to explore the current developments in the diagnosis and treatment of non-Hodgkin lymphoma (NHL).

The purpose of this review is to provide the haematologist with a working knowledge of the common inherited bone marrow failure syndromes (iBMFS)…

Chronic neutrophilic leukaemia (CNL), chronic eosinophilic leukaemia-not otherwise specified (CEL-NOS), and myeloproliferative neoplasm (MPN)…

Acute lymphoblastic leukaemia (ALL) in adults has a survival rate of 40–50% at 5 years, with a high relapse rate after first-line chemotherapy.

Spasmodic dysphonia (SD): what about it? That is the million-dollar question.

Ms Rosmarie Pfau detailed the challenges faced by patients with FL around the world, particularly a desire for improved quality of life (QoL) and…

Despite significant therapeutic advances in the treatment of patients with non-Hodgkin lymphoma (NHL), a significant proportion experience relapse or…

The main objectives of this symposium were to review the value of biosimilars in sustainable treatment for haematologic malignancies and to recognise the…

This symposium was dedicated to discussing BCR-ABL-positive chronic myeloid leukaemia (CML) and Philadelphia-positive acute lymphoblastic leukaemia (Ph+ALL)

There are ˜3,000 children, as well an additional ˜7,000 adults, diagnosed with acute lymphoblastic leukaemia (ALL) each year in the USA.

The actin cytoskeleton plays many important roles in the lifecycle of platelets, from biogenesis from megakaryocytes, to activation and clearance from…

The management of acute lymphoblastic leukaemia (ALL) remains challenging.

In 2016, an update on the classification of lymphoid neoplasm was published, and one of the modifications made focussed on B-cell lymphoma…

The myelodysplastic syndromes form a heterogeneous group of clonal disorders with an increasing incidence in the elderly population and an emerging…

Sickle cell disease is a genetic disorder caused by sickle haemoglobin. In many forms of the disease, the red blood cells can change shape upon…

Prof Munshi opened the presentation with a brief video highlighting the interaction of myeloma cells with the bone microenvironment…

Improved Clinical, Laboratory, Molecular, and Pathological (CLMP) 2017 criteria for myeloproliferative neoplasms (MPN) define the JAK2V617F trilinear…

The emergence of B cell receptor (BCR) kinase inhibitors has recently changed the treatment landscape in chronic lymphocytic leukaemia (CLL). The…

Non-transfusion-dependent thalassaemia (NTDT) is a rather broad term that encompasses a group of thalassaemia syndromes, most commonly β-thalassaemia…

Prof Robin Foà opened the symposium by highlighting how improving healthcare and an ageing population are increasing the burden on healthcare resources…

A recent symposium at the European Hematology Association (EHA) congress, chaired by Prof Eva Kimby, explored the changing paradigms in the treatment of…

Several rare haematological diseases are linked to bone marrow failure (BMF). This symposium provided the latest scientific insights into the different…

The treatment landscape for patients with multiple myeloma (MM) is constantly evolving. Over the past decade, the introduction of novel agents including…

Direct oral anticoagulants (DOAC) are used in several indications for the prevention and treatment of thrombotic events. As highlighted by data from…

Non-Hodgkin lymphoma (NHL) is the eighth most common malignancy worldwide. Diffuse large B cell lymphoma (DLBCL) is the most frequent subtype, accounting…

Inherited thrombocytopenias comprise a heterogeneous group of blood disorders with abnormalities in genes related to glycoproteins and adhesion molecules…

The next-generation sequencing era has repeatedly demonstrated that the amount of acquired somatic mutations in paediatric cancers can rarely account for…

Less than 50% of patients with adult acute lymphoblastic leukaemia (ALL) experience long-term survival and for those adults >60 years old, long-term…