Neurology

Polygenic risk may identify older adults most likely to benefit from aspirin for ischemic stroke prevention.

Ischemic stroke transfer rates show racial, ethnic, and insurance-based disparities across a nationwide U.S. registry analysis.

Air pollution may raise tinnitus risk, especially in people with higher genetic susceptibility, a large cohort study suggests.

IVIG may reduce seizure frequency in some children with drug-resistant epilepsy, especially those with generalized seizures.

New-onset constipation after stroke was common and independently linked to poorer discharge outcomes in acute rehabilitation.

Oral migraine preventives reduced headache burden in real world care, but tolerability varied sharply across commonly used drugs.

Cleft palate was linked to the highest rates of psychological and neurodevelopmental disorders across cleft subtypes.

Migraine prevention improved at 3 months in a real world study comparing galcanezumab with oral therapies. Read more.

CAR-T therapy improved mobility and stiffness in stiff person syndrome in a pivotal Phase II study.

Adults responsible for household food decisions often found ultra-processed foods confusing, despite linking them with poor health.

Ulixacaltamide maintained response in essential tremor in a Phase III randomized withdrawal study at AAN 2026.

Rapid whole genome sequencing delivered likely genetic diagnoses in nearly one quarter of hospitalized adults with unexplained neurologic symptoms.

A reasoning-based language model matched GPT 4.1 in predicting 90-day stroke disability from discharge notes.

New IBS research highlights persistent pain treatment gaps and points to peripheral nerve targets for future, safer therapies.

Ketamine showed moderate efficacy in super-refractory status epilepticus, with EEG and inflammatory markers linked to response.

Parenteral clomipramine showed no clear early advantage over oral therapy for depression, while evidence in OCD remained limited.

Inflammation and malnutrition may work together to worsen outcomes in acute ischemic stroke.

Parkinsonism trends in the UK reveal falling PD incidence, rising prevalence, and increasing recognition of vascular Parkinsonism..

Navigated transcranial magnetic stimulation improved PTSD outcomes when added to intensive residential therapy for combat-related symptoms.

Advanced practice nurse involvement improved PREEMPT interval adherence for chronic migraine patients receiving onabotulinumtoxinA in routine care.

Many ADHD care providers for children report school coordination gaps, with training and barriers shaping support.

Brief virtual therapy for anxiety in pregnancy was feasible, well accepted, and linked to reduced symptoms.

Stroke trunk control in acute ischemic stroke may be closely linked to resting posterior trunk muscle tone and stiffness.

Cerebral lymphatic dysfunction is emerging as a promising therapeutic target in Alzheimer’s disease treatment and research.

Migraine often becomes more frequent, severe, and harder to manage during the menopause transition in midlife women.

Practical judgment in aging was linked to scam engagement and brain connectivity in older adults without dementia.

Recent infection was associated with higher cryptogenic ischemic stroke odds in younger adults and linked biomarker changes.

Antiseizure medication shortages were linked to more seizure-related emergency visits and seizure clusters among adults with epilepsy.

Restorative neurostimulation improved pain, disability, and quality of life in patients with refractory chronic low back pain.

Hearing loss in mild cognitive impairment was common, but objective hearing measures did not differ significantly from controls.

Topiramate prophylaxis was linked to reduced cluster headache pain and disability in adults across this prospective cohort.

Adaptive artificial intelligence may reshape neuroplasticity, raising concern that cognitive autonomy could be gradually compromised.

Pompe disease management is evolving as next-generation enzyme replacement, gene therapy, and digital monitoring reshape decisions.

A remote physical activity intervention improved functional fitness in Alzheimer’s dyads despite unchanged daily MVPA overall.

Former American football players showed poorer cognitive and neuropsychiatric function, with symptoms worsening by exposure level.

In cervical dystonia botulinum neurotoxin injections improved sleep quality but did not ease anxiety or depression in adult cohort.

Frequent dancing was linked to substantially lower dementia risk in older adults followed for two decades.

A recently published case study suggests life story narration in bipolar disorder can solidify with time, into a coherent, emotion shaped worldview.

Systematic review outlines diagnosis and rehabilitation for dysphonia after spinal cord injury noting key tools and remaining gaps.

Severe gum disease was associated with mild cognitive impairment risk, in middle-aged periodontitis patients, researchers report.

In rural older adults, frailty and reduced chewing performance were linked to a higher risk of malnutrition in southern Taiwan too.

Functional neurologic disorder is a positive-sign diagnosis and patient perspectives show why early empathic communication matters.

Resistance exercise slowed brain aging clocks by up to 2.3 years using longitudinal rsfMRI neuroimaging data.

In adults with tuberous sclerosis complex, add-on cenobamate improved executive function, quality of life, and stress.

In a U.S. emergency TIA observation cohort, transthoracic echocardiography found high-risk cardioembolic features in one in five.

Matched lesion stroke analysis found hemorrhagic stroke caused worse disability and higher DALYs than ischemic stroke by year five.

Herpes zoster vaccination was associated with reduced dementia diagnoses in elderly Canadian adults throughout natural experiments.

Mobile application engagement may predict clinically meaningful pain reduction for adults with chronic pain and hazardous drinking.

AI-derived radiology phenotypes improved stroke mortality prediction, when added to structured EHR data in acute stroke admissions.

Inspiratory muscle training strengthened diaphragm measures, and inspiratory strength in subacute stroke participants in six weeks.

Digital Neuro Fingerprints may transform dementia monitoring, by merging smartphone signals into clinically meaningful risk scores.

Dengue is increasingly affecting older adults since 2024 complicating diagnosis as severe outcomes increase worldwide dramatically.

Across surveys, stress, obesity, and physical inactivity were the Health Risks consistently linked to chronic conditions.

Convection-enhanced delivery in pediatric patients produced mild adverse events in most studies with no Grade 4 or 5 toxicity seen.

Chronic ocular surface pain may reflect nociplastic CNS dysfunction and will be phenotyped using comprehensive characterization.

Real-time location data revealed rest-activity rhythm phenotypes in advanced dementia well tracking sleep disruption and agitation.

Ischemic stroke during pregnancy occurred more often after prior ischemic stroke, with elevated odds through 6 week early postpartum.

Transverse colon tissue in Alzheimer’s disease showed gut microbiome and proteome profile very closely tied to pathology in adults.

Longer elevated perfusion pressure after ROSC was linked to better 6-month neurological outcomes in out-of-hospital survivors.

Mechanical thrombectomy with CT perfusion helped recovery 28 hours after sudden symptom onset in a 34-year-old with ICA dissection.

A new review details ketogenic diet contraindications, adverse effects, and drug interactions across routine clinical contexts now.

Early DAPT after minor stroke or high-risk TIA lowered 90-day recurrent stroke, MI, or death when started within 24 hours of onset.

Adult childhood cancer survivors demonstrated accelerated brain aging that tracked with cranial radiation and poorer neurocognition.

In MONEAD, most pregnant women with epilepsy required antiseizure medication dose increases, followed by early postpartum tapering.

Children with neurodisability had increased hospital admissions and school absences across primary school, nationwide records show.

Oral bacteria and Alzheimer’s disease may be linked as periodontitis inflammation could promote neurodegeneration, authors suggest.

Mental imagery after stroke was positively associated with cognitive performance during early rehabilitation, but it did not predict functional independence outcomes.

Deliberate self-harm affected most adolescents with over-the-counter (OTC) related psychiatric disorders in a nationwide Japanese analysis.

ADHD often manifests after milder pediatric traumatic brain injury in children, underscoring necessity for prolonged followup care.

Longer reproductive lifespan appears to reduce dementia risk among postmenopausal women living with type 2 diabetes.

Autoimmune diseases are associated with higher dementia risk and cognitive impairment in a nationwide Korean cohort.

To explore sex specific effects of stroke on motor performance, investigators studied 41 chronic stroke survivors at least six months after stroke and 23 age matched neurotypical adults.

Autistic young people and those with ADHD face barriers when transitioning to adult mental health services.

New interdisciplinary guidance reframes persistent idiopathic facial pain as a shared challenge for neurology and dentistry.

The authors of this neuroscience review synthesize human and animal data on prenatal cannabis exposure, with a particular focus on the developing immune system.

Community data suggest trichotillomania and pregnancy are linked to mostly stable or improved hair pulling and skin picking symptoms, though a subset of women report perinatal exacerbations.

Holiday weight gain in college students appears modest, with increases driven more by lean mass than fat.

Insomnia appears to causally increase generalized epilepsy risk, underscoring sleep traits as modifiable targets in epilepsy care.

Emerging evidence links gut microbiota dysbiosis with overlapping neuropsychiatric disorders and chronic inflammatory skin disease.

Snow cover light exposure may suppress morning melatonin and improve alertness for residents at northern latitudes.

GLP-1 receptor agonists show robust neuroprotection in stroke models, yet human clinical benefits remain uncertain so far.

Hand dexterity in brain tumors appears more closely linked to brain network connectivity than traditional tumor features.

A structured quality improvement program significantly increased sleep apnea testing after ischemic stroke and transient ischemic attack in a large Veterans Affairs cohort.

Investigators are testing whether targeting the gut–brain axis can improve seizure control and neurological symptoms in CDKL5 deficiency disorder.

The study found perceived stress and loneliness significantly correlated with adolescent game addiction during the pandemic transition period.

Achalasia hospitalizations in the US increasingly feature POEM adoption alongside rising patient complexity.

This study found multiple distinct immediate causes of death in pediatric cerebral malaria.

Epilepsy affects more than 4 million adolescents worldwide, with rates remaining stagnant over the past three decades.

Tiny brain-like organoids, sometimes called “mini brains”, are at the center of a bold new approach to computing that merges biology with technology.

Repetitive head impacts and prior concussion can alter cortical microstructure in young athletes.

The controversial role of therapeutic hypothermia in traumatic brain injury continues to divide clinicians, as recent findings reveal conflicting effects on survival and neurological outcomes.

A single session combining transcranial direct current stimulation and virtual reality-based mindfulness may enhance attention regulation.

Tramadol with CYP2D6-inhibiting antidepressants was associated with higher seizure rates in nursing home residents in Medicare.

Neurocognitive functioning declines across central nervous system cancers, shaped by tumor location and interacting treatment effects.

In adults with Down syndrome, metabolic syndrome was uncommon, but obesity associated with Alzheimer’s dementia risk.

Gout flares affect one in twenty stroke patients within a week, often the paretic limb, unveiling undiagnosed hyperuricemia.