Allergy & Immunology

Symptoms experienced over the past week were common and impactful, with over half of the participants reporting dysphagia and nearly half experiencing heartburn.

These findings suggest that most children can maintain tolerance to nuts even after a short period without exposure, following a structured course of N-OIT.

Conducted across 19 countries, this large-scale observational study gathered data from 1,392 patients with CSU and 1,374 healthy controls.

This study investigates the role of the intranasal Schirmer test as a supportive or alternative tool to anterior rhinomanometry for allergic rhinitis.

Discover a study that highlights the importance of identifying high-risk children through biomarkers and better understanding neutrophil function in RSV infection.

Moreover, the infant’s gut microbiota may play a role in both allergy development and tolerance.

Interestingly, the study also revealed a disconnect between clinical and biological remission.

The study highlights a potentially critical role for the BDNF-NTRK2 pathway in symptom development.

This study is especially important because existing diagnostic methods, including skin testing, have shown limited sensitivity.

The PHECDA trial evaluated stapokibart as an add-on therapy during pollen season in adults with moderate-to-severe seasonal allergic rhinitis.

Discover a study that found that 58.8% of shrimp-allergic patients also had allergic rhinitis, and 11.7% had asthma. Learn more.

Children with septic shock who received ulinastatin alongside standard therapy showed significantly improved clinical outcomes.

Excessive anxiety surrounding food allergies is common and can significantly impact a patient’s quality of life.

A novel CAR T cell therapy has shown encouraging results in children and adults with relapsed/refractory B-cell acute lymphoblastic leukaemia.

Each year, up to 138,000 people die and around 400,000 more are left permanently disabled from snakebites.

Researchers have explored the potential of intense pulsed light therapy as a supplementary treatment for refractory SAC.

The analysis demonstrated significant reductions in HAE attacks among adolescent patients.

Researchers developed a new evolutionary framework centred on immune robustness, the ability to fight infection while limiting damage.

A recent randomised clinical trial sought to determine whether high-dose aspirin remains necessary during acute-stage KD treatment.

The RILECSU phase 2 clinical trial has introduced a potential new option: rilzabrutinib.

During the immunosuppressive phase, researchers identified a marked decline in monocyte function and maturation.

Researchers have discovered a myeloid-derived APC population that is essential for generating both food- and microbiota-specific peripherally induced regulatory T cells.

The study suggests that initiating Artemisia annua SLIT during the pollen season is just as safe and well-tolerated as starting it before.

The results suggest that Wendan Decoction and acupuncture into treatment plans may enhance clinical outcomes for patients with urticaria.

A recent single-blind, randomised controlled trial evaluated the efficacy of normal saline nasal irrigation in managing allergic rhinitis symptoms.

The study found gluten-derived excipients in 44.4% of analgesics and antipyretics.

Over half of the studies identified a direct link between climate change and extended pollen seasons.

The revised mRNA-1010 formulation, evaluated in a subsequent trial, met all primary immunogenicity goals.

The study suggests that chronic inflammation caused by allergic rhinitis could contribute to carcinogenesis through oxidative stress.

Mental health concerns were prevalent, with nearly all families experiencing stress.

This study aimed to assess whether maternal exposure to LC-PCBs in indoor air during pregnancy was associated with the development of asthma.

The study also highlighted a reduction in restricted antibiotic use among patients in the intervention group compared with the control group.

This study explored the hypothesis that mucus transpiration contributes to airway inflammation and chronic respiratory disease.

While food additives play a crucial role in food preservation and enhancement, their potential long-term effects on immune and metabolic health remain a growing concern.

Recent research has identified microRNAs as crucial regulators of inflammation, offering potential new insights into allergic rhinitis pathogenesis.

Beyond antibody transfer through the placenta, breastfeeding may further enhance infant protection.

Discover why new research suggests that early and consistent exposure to food allergens may influence the development of tolerance.

Rocatinlimab, a novel therapy targeting the OX40 pathway, shows potential as an alternative treatment.

Current treatments focus on managing symptoms and include moisturisers, corticosteroids, and calcineurin inhibitors.

Recent studies demonstrate that IL-5 treatment substantially increases type I and III IFN production in mast cells exposed to respiratory viruses.

The Clinical Support Tool is a significant advancement, integrating clear clinical criteria and epinephrine treatment guidelines.

Given that 60% of asthma-related costs are attributed to severe, uncontrolled cases, the need for cost-effective treatment alternatives is crucial.

These findings indicate that omalizumab is a more effective and safer option than multi-allergen OIT for treating multi-food allergy.

Fine dust, a notable seasonal allergen, exacerbates allergic rhinitis symptoms and contributes to respiratory diseases.

Peanut oral immunotherapy using home-measured peanut butter significantly improves long-term desensitisation in children with high-threshold peanut allergy.

A proof-of-concept study was conducted to explore whether dupilumab could induce desensitisation to peanut in children with peanut allergy.

These findings suggest that vonoprazan and tetracycline dual therapy is both effective and well-tolerated, offering a valuable alternative.

These findings suggest that a preoperative radiation therapy boost can safely induce a short-term increase in stromal tumour-infiltrating lymphocytes.

The ability to pharmacologically degrade fat mass and obesity-associated protein represents a promising avenue for enhancing anti-tumour immunity.

Immune checkpoint inhibitors represent an exciting avenue for managing field cancerisation and reducing the keratinocyte carcinoma burden.

These findings highlight a host-intrinsic mechanism responsible for the failure of PD-L1 blockade in ovarian cancer.

The study highlights the necessity of a third vaccination to detect neutralising activity, particularly against emerging Omicron subvariants.

New research maps immune system changes across the human lifespan, revealing key insights into aging and health.

A recent study investigated the efficacy of peanut oral immunotherapy using home-measured peanut butter compared to strict peanut avoidance in children.

Fractionation techniques can significantly enhance the identification of bioactive peptides and immune-related proteins in camel and cow milk.

The findings indicate that preschool wheeze has a profound impact on families, creating high levels of worry and restricting parents’ ability to work and travel.

Targeting RELMβ may provide new therapeutic strategies to prevent severe allergic reactions and improve patient outcomes.

The newly recommended immunotherapy works by gradually increasing the body’s resistance to house dust mites.

New research finds that a mother’s allergic disease and the season of her infant’s birth significantly influence the composition of the breast milk microbiome.

Early ACQ-5 score predicts mepolizumab treatment success in severe eosinophilic asthma, guiding clinical decisions.

New data from the COVAIL trial highlight the importance of neutralizing antibody titers in reducing COVID-19 risk after mRNA boosters, with stronger protection observed in individuals with prior SARS-CoV-2 infection.

This study highlights the potential of probiotics as an adjunct treatment for allergic rhinitis, offering symptom relief and improving quality of life.

Hydrolysed rice formulas offer unique advantages, such as accommodating cultural, religious, and economic preferences.

Specialist allergy care cuts asthma emergencies in Medicaid-enrolled children, improving outcomes and reducing healthcare visits.

By leveraging the immune-activating properties of epithelial cells, this study highlights the transformative potential of Th2 immunity in early cancer intervention.

A recent study explored a baked milk oral immunotherapy protocol for children with severe cow’s milk allergy.

These findings show the potential of nasal transcriptomic profiling to classify asthma into endotypes, which could inform tailored therapeutic approaches.

Atopic dermatitis, an allergic skin condition characterised by inflammation and heightened IgE levels, is often worsened by psychological stress.

EPIT shows promise in desensitising food allergy patients, but raises concerns about increased adverse events.

Food allergen exclusion increases psychosocial stress in families. Clinician support could improve food allergy management and well-being.

Trigger-specific patterns in anaphylaxis improve diagnosis and treatment, reducing delays in life-saving emergency care.

Multimodal therapy demonstrates superior efficacy in managing allergic rhinitis.

This study highlights that both the 2-dose and 3-dose HepB-CpG regimens provide better seroprotection compared to the 3-dose HepB-alum regimen.

These findings provide new insights into how circadian rhythms, through mitochondrial regulation, contribute to inflammatory responses.

Results showed that ending universal testing and masking correlated with a notable increase in hospital-onset respiratory viral infections compared to community-onset cases.

These findings provide insights into COVID-19’s underlying mechanisms, suggesting targets for interventions that could mitigate severe disease outcomes.

Elevated total immunoglobulin E levels are associated with atopic dermatitis, but IgE levels cannot reliably evaluate AD severity.

Increased exposure to ambient PM2.5 and NO2 is associated with a modestly increased risk of incident adult asthma

Neonatal gut microbiota composition is significantly associated with the risk of developing food sensitisation and food allergy

A global survey highlights the challenges faced by individuals with food allergies during air travel.

Fibre-rich diets promote beneficial microbiota, producing short-chain fatty acids that enhance immune functions.

Benralizumab has shown efficacy in reducing asthma exacerbations and controlling symptoms in severe eosinophilic asthma.

Parental anxiety improved initially, while adults reported better problem-focused coping and reduced depression over 3 months.

The results revealed a clear impact as vaccination rates rose by 1.8% among heart attack survivors and by 1.3% in adults without a history of heart attack.

Findings from the VOYAGE and EXCURSION studies confirm the efficacy of dupilumab in children aged 6–11 years with moderate-to-severe type 2 asthma.

In a small Swiss study, patients with adult-onset egg white allergy exhibited moderate to severe restrictions in daily life.

Dysbiosis, or microbial imbalance, can predispose individuals to allergies, while a balanced gut microbiome fosters immune tolerance.

The trial highlighted that the Zagreb regimen led to fewer doses and a shorter vaccination period, improving compliance and cost-effectiveness.

The trial found increased beneficial gut bacteria such as Lactobacillus and Bifidobacterium, alongside reduced pro-inflammatory species.

A recent study explored the effectiveness of four treatment protocols, including nasal corticosteroids and antihistamines for children with allergic rhinitis.

Between 1990–2010, the number of African children with asthma rose from 34 million to 50 million, driven partly by increased urbanisation.

This variant results in reduced STAT6 protein levels, dampened IL-4 responses, and lower IgE and eosinophil counts in the blood.

The trial included 135 adults, randomly assigned to receive either inebilizumab or a placebo for a 52-week treatment period.

In the trial, patients received either IL-2 (1 MUI/day) or a placebo for 5 days, followed by weekly doses for 4 weeks.

The study aims to customise CIC profiles for patients, providing insights into which stages of the cycle are most relevant for tailored cancer therapies and diagnostics.

he study aimed to evaluate how gestational age at the time of vaccination and the time elapsed until delivery impacted antibody levels in the newborn.

Groundbreaking research from Emory University has revealed that autoantibodies found in the nasal cavity may provide a critical defence against severe COVID-19 symptoms.

A recent review reveals significant racial and ethnic disparities in FOIT clinical trials.

A recent systematic review and meta-analysis highlights concerns about antibiotic resistance in Staphylococcus aureus strains found in individuals with atopic dermatitis.

A case study from ACAAI highlights the health risks of incense burning, particularly affecting respiratory health.

Seasonal allergies, which affect around 26% of Americans, come with significant economic and productivity costs, especially as climate change drives higher pollen and mould levels.

Vaccines play a critical role in preventing respiratory infections by limiting virus circulation, especially in the case of COVID-19.

The Hoxb8 mast cell activation test (Hoxb8 MAT) shows high diagnostic accuracy in identifying peanut allergies.

New data reveal a more than 50% increase in psychology referrals for food allergy-related anxiety at one centre in 2023 compared to the previous four years.

Transplant-acquired food allergy is an emerging concern in paediatric organ transplant recipients, particularly in liver transplants

Managing food allergies has seen significant advances, including food immunotherapy as an option for desensitisation and preventing severe allergic reactions.  

New research reveals the significance of the airway microbiome in severe asthma, especially in ‘type-2 low’ neutrophilic asthma. 

A study has demonstrated that electronic letters informed by behavioural science can significantly increase influenza vaccination rates in chronically ill patients.

A study links indoor allergens, particularly cockroach and mouse allergens, to increased upper respiratory infections in children with asthma from disadvantaged communities.

MRD negativity and clonal diversity in multiple myeloma patients predict better survival, according to a UCSF study using next-gen sequencing.

Recent research underscores the long-lasting benefits of early peanut introduction in preventing peanut allergy.

A new study shows that allergy immunotherapy may offer relief for young children with allergic rhinitis while also reducing asthma risks.

Childhood obesity is associated with an increased risk of developing paediatric immune-mediated skin diseases, such as atopic dermatitis, according to recent research.

The prevalence of food allergy in England has increased significantly, according to recent research.

A new study has highlighted the significant role of human rhinovirus (RV) in triggering acute wheeze episodes in children and adults which are often accompanied by bacterial coinfection

In populations exposed to strong variations in weather conditions between seasons, a person’s season of birth (SOB) has been associated with several non-communicable diseases

A study from Vienna reveals persistent immune changes, including shifts in cell counts and cytokine profiles, up to 10 months post-COVID-19 infection

Allergies to non-priority legumes like beans and chickpeas are increasing with the rise in plant-based diets. A new review highlights the need for more research on these allergens.

Recent findings suggest that dupilumab, a monoclonal antibody treatment for atopic dermatitis, may significantly reduce the risk of atopic march in children.

Novel research has identified a strong connection between early-life respiratory tract infections and the development of asthma in children, particularly in children with allergic rhinitis.

Optimising formaldehyde-related allergen selection in patch testing for allergic contact dermatitis reduces costs while maintaining high capture rates.

Consistent peanut consumption, starting in infancy and continuing to 5 years of age, provides a lasting tolerance to peanuts which continues into early adolescence.

New research has revealed that egg-induced anaphylaxis in children presents with unique symptoms, differing from other food allergies.

A link between cold temperatures and asthma flare-ups in children, mediated by oxidative stress in the nasal cavity, has been identified in recent research.

An increased risk of antibiotic-resistant infections, for up to 12 years, is associated with β-lactam allergies, according to recent research.

Reduced intake of dietary sodium may be a cost-effective and low-risk treatment for atopic dermatitis (AD), according to recent research.

The cross-sectional study included 154 children previously diagnosed with FPIAP and compared them to 100 children with IgE-mediated cow’s milk allergy

Pollen food allergy syndrome (PFAS) affects a significant portion of birch pollen allergy sufferers

A new study has found that high HbA1c levels, consistent with pre-diabetes, are linked to poor asthma control in paediatric patients

A study reveals promising results for managing IgE-mediated food allergies with immunotherapy and biologics

According to new research oral immunotherapy shows promise in improving cow’s milk allergy

Recent research has found that completely avoiding milk products due to cow’s milk allergy can impact growth and bone health.

This study aimed to understand the association between asthma medication use, asthma exacerbation, and maternal and neonatal outcomes, discovering no direct link. Read more.

Research shows direct oral penicillin challenges can be delivered safely and effectively to patients with PALs by non-allergy healthcare professionals, mitigating antimicrobial resistance.

New research presented at the American Academy of Allergy, Asthma & Immunology Annual Meeting reveals a potential link between transepidermal water loss (TEWL) and the severity of peanut allergy reactions.

Maternal diet and environment in pregnancy may influence allergies in children, despite guidelines claiming that diet during the prenatal period has little to no effect on food allergy symptom development in early infancy.

Proton pump inhibitors (PPI) in infancy have been linked to an increased food allergy risk, according to data presented at the 2024 American Academy of Allergy, Asthma & Immunology (AAAI) Annual Meeting in Washington, D.C., USA.

Low filaggrin (FLG) expression in children aged 2–3 years has shown to be a predictor of asthma, according to novel research presented at the 2024 American Academy of Allergy, Asthma & Immunology Annual Meeting in Washington, D.C., USA. 

Home reintroduction of paediatric food protein-induced enterocolitis syndrome (FPIES) food triggers may be safe for carefully pre-selected children, according to new research presented at the American Academy of Allergy, Asthma & Immunology (AAAAI) 2024 Annual Meeting.  

New research, presented at the 2024 American Academy of Allergy, Asthma & Immunology Annual Meeting, suggests that early skin microbiome and metabolome may be predictive of atopic dermatitis in infants aged 6–18 months.

Daycare attendance is protective against perennial allergen sensitisation, according to new research presented at the 2024 American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting, held in Washington, D.C., USA, from February 23rd-26th 2024.  

Desensitisation to baked and unheated milk has been achieved using baked milk oral immunotherapy (BMOIT), according to data presented at the 2024 American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting, which took place in Washington, D.C., USA, from February 23rd-26th 2024. 

Currently, many people with hay fever monitor pollen to manage their symptoms. This study suggests that measuring allergen levels instead will be a more accurate test. Read more.

Electronic healthcare records have allowed researchers to identify inequalities in the care of patients after they have been hospitalised due to an asthma attack. Read more.

Children with atopic dermatitis are more likely to develop other skin conditions. Despite this, researchers reported that many children with AD are not referred for patch testing, and ACD is often underdiagnosed.

According to new research, the chance of developing anxiety and depression is increased in patients with atopic dermatitis, mostly when additional allergic symptoms are present.

According to research, oral immunotherapy can safely desensitise children under a year old to peanuts. Read more…

Participation in exercise programmes has brought about improvement in the lung function of adults with asthma…

The number of treatable traits independent of pharmacological care is associated with asthma control and quality of life…

Simultaneous oral immunotherapy for multiple foods is feasible and safe via established protocols. Read to find out more…

Serious gaps in knowledge make it difficult to precisely identify risk factors for severe allergic reactions to food…

The Centers for Diseases Control and Prevention currently does not recommend using the nasal spray flu vaccine in children with asthma…

Study finds that uncontrolled asthma in children is linked to an elevated risk of COVID-19-related hospitalisation…

Peanut allergy in children affects almost 1.5 million of the United States’ population aged 17 and younger…

Recent reports have also found dangerously high levels of toxic heavy metals, including cadmium, in several brands of baby food…

The research further suggests that the minimal allergic reactions could be avoided by manufacturers through the reformulation of vaccines…

Consumers play a role in the risk of eating food that contains allergens, but it is also important there are clear guidelines for allergy information in products to ensure risks are understood.

THE SECOND COVID-19 mRNA vaccine dose has been established as safe from allergic reactions that were experienced in the first dose, says a multi-hospital analysis led by allergists from Massachusetts General Hospital (MGH), USA.

This predicted, with a high degree (76%) of accuracy and more reliably than ever before, whether an infant would develop allergies by 1 year of age…

However, severe allergic reactions created a potential barrier to large-scale vaccination rollout. For this reason, academics at Massachusetts General…

FOOD allergy affects up to 26 million members of the European population and poses a substantial public health burden. Fortunately, researchers from…

CAT allergies are among the most common allergies, affecting between 10 and 20% of the global population. Symptoms range from mild-to-moderate conditions…

Although there was variation between individual patients’ antibody levels, the researchers found the overall trend of rapid reduction to be consistent.

Allergic responses can be passed to newborns: a recent research demonstrates the effect of antibodies crossing the placenta during pregnancy.

DIFFERING immune system responses of patients with COVID-19 indicate which patients are at greater risk of developing severe forms of the illness…

MEMORY T cells that recognise common cold coronaviruses may teach the immune system to recognise matching sites on SARS-CoV-2, explaining why…

RETIREMENT of blood or pinprick testing for allergies may be on the horizon, with nasal smears showing promise for detecting allergen-specific antibodies…

EARLY identification of babies at risk of asthma, wheeze, and nasal blockage may now be possible due to the discovery of a link to a gene defect…

A VACCINE candidate for COVID-19 has shown promise in mice studies by producing antibodies specific to SARS-CoV-2, at levels thought to be sufficient…

Bactiguard launched the disinfectant HYDROCYN aqua® in Sweden at the beginning of March and, since then, demand has been high.

BISPHENOL A (BPA) is a compound that can mimic oestrogen and is found in plastic containers. It has been suggested that low-level exposure…

A NOVEL treatment option for allergic contact dermatitis has been suggested in a new study which looked at how lipids in the skin…

Coeliac disease (CD) is an autoimmune disease which leads to damage in the small intestine as a result of dietary gluten. CD affects about 1% of the…

Birthweight could be linked with childhood allergy, according to a recent study by a group of researchers…

MOISTURISER, particularly when used in the early stages of a child’s life, can help prevent the development of food allergies, hay fever, and asthma later…

SEVERE allergic reactions to bee venom can be more effectively prevented by a new vaccine containing a novel adjuvant called Advax, according to…