Dermatology

Actinic keratosis may be driven by inflammation and microbiome imbalance alongside ultraviolet-induced genetic damage.

Environmental and lifestyle exposures significantly influence acne development through complex biological and social mechanisms.

Psychopharmacology is emerging as a critical tool in dermatology, with growing evidence supporting its role in managing both skin conditions and associated psychiatric disorders.

AI tools may help consumers identify skin conditions more accurately, but guidance on next steps still needs improvement.

Vitiligo stigma varies across cultures, but its psychological toll is global, severe, and too often underestimated.

Cosmetic adverse reactions may cause lasting skin damage, especially in younger patients and those with allergy histories.

A new skin cancer risk stratification tool for solid organ transplant recipients shows strong international validation but inconsistent clinical adoption.

Truncal acne may require more tailored treatment because truncal skin differs structurally and functionally from facial skin.

Deucravacitinib showed strong short-term psoriasis responses and excellent scalp clearance in real-world clinical practice.

Cell-free secretome therapy restored hair growth in preclinical androgenic alopecia models by protecting papilla cells.

Patients with severe alopecia areata treated with upadacitinib achieved greater hair regrowth at Week 24 versus placebo.

Patients with moderate-to-severe atopic dermatitis showed generally low long-term upadacitinib safety event rates across ages.

Continuous secukinumab treatment showed sustained hidradenitis suppurativa lesion control through 4 years in responding patients.

Remibrutinib improved itch and hive severity within 12 hours in chronic spontaneous urticaria in Phase III analysis.

Serum sickness after botulinum toxin type A may signal a rare delayed systemic immune reaction. Read more.

Microneedle patches may improve hyperpigmentation treatment by enhancing skin delivery, efficacy, and tolerability of active agents.

Definisse KP1 eye contour cream may enhance eye rejuvenation when combined with onabotulinum toxin A. Read more.

Fractional CO2 laser improved post-acne scars more than microneedling radiofrequency, but with greater pain and downtime.

Delgocitinib cream significantly improved quality of life in adults with moderate to severe Chronic Hand Eczema (CHE) in pooled phase III trial data.

Abrocitinib appears durable and well tolerated in patients with moderate-to-severe atopic dermatitis (AD), also known as eczema, according to a 2-year retrospective real-world study.

Pazopanib shows activity and manageable safety in paclitaxel-pretreated cutaneous angiosarcoma, offering a potential second-line therapy option.

Patch testing in hand and foot eczema frequently showed no allergen, yet potassium dichromate topped positive results overall here.

Analysis finds 2030 skin-related neglected tropical diseases milestones off track as DALYs increase heterogeneously across nations.

Large language models in glaucoma show promise for education and decision support, yet performance varies widely.

GPT-4 learning models in dermatology demonstrated substandard information yet rarely offered harmful advice in evaluation, overall.

Roflumilast for psoriasis improved Global Assessment scores and was well tolerated versus placebo by Week 8 in a systematic review.

After vunakizumab discontinuation, many plaque psoriasis patients maintained PASI 90, but BMI and interruptions predicted relapses.

Botanical extracts provided negligible nutrition however could increase element exposure; inorganic arsenic and lead were concerns.

Mini-CEX self-assessment training plus feedback improved dermatology residents’ exam skills and rating alignment well in practice.

Perioperative liposomal bupivacaine injections showed minimal adverse events in 129 dermatologic surgery patients in a new review.

A review found seven hidradenitis suppurativa patient-reported key outcome measures, with HiSQOL-17 performing best across studies.

Risankizumab delivered sustained psoriasis clearance and reduced subclinical inflammation on OCT imaging across 52 weeks follow-up.

Real-world PsoBest data show apremilast improved psoriasis severity, involvement, and quality of life over 12 months in usual care.

An overview highlights combination strategies that improve stretch marks through Fitzpatrick phototypes in practice for clinicians.

Real-world meta-analysis found tildrakizumab substantially improved plaque psoriasis severity and quality of life through 52 weeks.

Indoor tanning bed use substantially raises melanoma, BCC, and cSCC risks, underscoring this well-established carcinogenic profile.

In children, deficiencies in zinc and vitamin D independently increased tinea capitis risk and lowered 8-week clinical cure rates.

Bimekizumab showed the strongest short-term efficacy among hidradenitis suppurativa biologics in trials assessed at Week 12 to 16.

Chronic spontaneous urticaria in SLE was not linked to higher disease activity, but was associated with distinct clinical and laboratory risk factors.

Large spot picosecond lasers potentially improve dermal pigment clearance in Asian skin while reducing perilesionaltissue exposure.

Abrocitinib treatment can be personalized in moderate-to-severe atopic dermatitis using flexible dosing to meet disease trajectory.

A cross-sectional study has found variability in how ChatGPT performs when asked to generate informed consent forms for cosmetic dermatology procedures that use lasers and energy-based devices.

In Mohs patients, keratinocyte carcinoma quality of life worsened more with younger age, female sex, and field cancerization class.

Better metabolic control may meaningfully lower psoriatic arthritis risk for many patients living with psoriasis today.

New research suggests salivary oxidative stress markers alone may not distinguish active from inactive Behcet’s disease.

Lasers and energy-based devices may target cellular senescence, potentially rejuvenating aging skin at a fundamental molecular level.

Intradermal botulinum toxin A for post acne erythema outperformed broadband light in this split face randomized controlled trial.

Skin cancer is a growing global public health problem, and green spaces are usually considered health promoting environments.

A 10% urea-based moisturizing lotion rapidly improved lower-leg xerosis and quality of life in older adults.

Emerging evidence links gut microbiota dysbiosis with overlapping neuropsychiatric disorders and chronic inflammatory skin disease.

Network meta-analysis suggests newer chronic hand eczema monotherapies differ in efficacy based on HECSI score reductions.

A split-level folding step-type tension-relieving suture technique improved wound tensile strength and collagen remodeling versus standard sutures in a preclinical model.

Tralokinumab improved disease control for many adults with moderate to severe atopic dermatitis after dupilumab failure.

Mechanical nail disorders may underlie many dystrophic toenails that are often mistaken for primary onychomycosis.

Prenatal exposure to endocrine-disrupting chemicals appears associated with an increased risk of childhood atopic dermatitis according to a growing body of epidemiological evidence.

Acne recurrence may be predicted with high accuracy using a new early warning model that incorporates both lifestyle and psychological risk factors.

Testing shows poor-quality sunscreen products can contain no UV filters and offer no true UV protection.

The specialty choices of underrepresented students in US medicine are strongly influenced by clinical exposure lifestyle factors and mentorship within chosen fields.

A recent survey across two UK hospital sites reveals that foundation doctors lack confidence in key dermatological skills, leading to misaligned expectations.

Autologous platelet-rich plasma injections were shown to safely enhance hair density and thickness in patients with androgenetic alopecia.

Oral JAK inhibitors are associated with measurable increases in lipid levels, emphasizing the need for vigilant cardiovascular monitoring during treatment.

A new AI-based simulator integrating dermatologist expertise predicts how tobacco use accelerates facial aging over 15 years.

Patients with acne who understand and routinely use basic skincare report milder disease in this cross-sectional study.

In a retrospective analysis of 151 cases, low level laser therapy achieved the highest satisfaction and perceived effectiveness for burning mouth syndrome treatment.

Melanoma quality of life differs during and after immunotherapy, with fatigue, skin issues, and sexual dysfunction.

Network meta-analysis ranks brucellosis treatment regimens, finding triple-drug combinations outperform widely used dual therapies.

Children with moderate-to-severe generalized pustular psoriasis (GPP) benefit significantly from biologic therapy.

Cutaneous venous malformations (cVMs), rare vascular anomalies marked by progressive vessel dilation, pain, ulceration, and bleeding, may be more prevalent in the US than previously recognized.

Helical tomotherapy combined with paclitaxel demonstrated encouraging survival outcomes with manageable toxicity in patients with cutaneous angiosarcoma.

Adalimumab use in patients with hidradenitis suppurativa (HS) appears safe with appropriate prophylaxis, as no cases of hepatitis B virus (HBV) or tuberculosis (TB) reactivation were observed in a large retrospective analysis.

Dupilumab may provide meaningful relief for patients with chronic kidney disease who experience uremic pruritus and for those with atopic dermatitis complicated by renal impairment, according to a retrospective real-world study.

Oral JAK inhibitors appear effective and safe in the treatment of vitiligo, according to a retrospective study evaluating real-world outcomes in nearly 100 patients.

Children under 12 years with moderate to severe atopic dermatitis experienced varying outcomes with systemic therapies, according to new real-world data from the PEDISTAD registry.

Cutaneous vasculitis in primary Sjögren disease is linked to significantly worse outcomes, particularly when cryoglobulinemic vasculitis is present, according to findings from a large multicenter cohort study.

Patients with psychophysiological skin disorders such as atopic dermatitis, psoriasis, pruritus, and alopecia experience measurable benefits in post-traumatic growth when they receive emotional and informational support, according to new research.

Scalp cutaneous metastases from breast carcinoma may present with varied clinical patterns, and new research highlights distinct dermoscopic features that could aid earlier recognition.

Platelet-rich plasma (PRP) therapy significantly enhances the healing of diabetic foot ulcers compared with standard wound care, according to findings from a randomized controlled trial that assessed both clinical outcomes and histopathological changes.

Scalp micropigmentation (SMP) demonstrated effective and safe cosmetic improvement for patients with localized alopecia, according to a technical analysis and case series.

A new U.S. analysis of patient experiences with psoriatic disease highlights significant diagnostic delays, emotional burden, and potential underdiagnosis of psoriatic arthritis (PsA).

Adults with psoriasis may be more likely to also have chronic bronchitis, according to new U.S. population-based findings.

Children with erythropoietic protoporphyria (EPP) frequently endure severe, unexplained pain triggered by sunlight or artificial light exposure, yet diagnosis is often delayed despite distinctive clinical features.

Stiffness and swelling were identified as the most reliable clinical indicators distinguishing psoriatic arthritis from non-inflammatory musculoskeletal conditions in patients with psoriasis, according to a retrospective review from a combined rheumatology-dermatology clinic.

Oral probiotics may offer therapeutic benefits for patients with acne, according to a new systematic review and meta-analysis of randomized trials.

Chronic pruritus, the hallmark symptom of atopic dermatitis (AD), is driven by a relentless itch–scratch cycle that can persist despite clinical improvements from conventional therapies.

Patients with psoriasis initiating biologic therapy, particularly tumor necrosis factor (TNF) inhibitors, may have a reduced long-term risk of developing primary malignancies compared with biologic-naïve individuals, according to a large retrospective cohort study.

Robotic-assisted techniques could one day enhance the precision of Mohs micrographic surgery (MMS) for rare cutaneous sarcomas such as dermatofibrosarcoma protuberans (DFSP), but current technology remains ill-suited for skin-level applications, according to recent research.

The clinical legitimacy of topical steroid withdrawal (TSW) remains a point of contention among dermatologists, according to new survey data from Australian specialists.

Real-world data on atopic dermatitis (AD) treatment has revealed that while current treat-to-target (T2T) strategies are feasible, several clinical targets may require refinement to better reflect meaningful outcomes.

A recent cross-sectional study sheds light on the knowledge, perceptions, and practices surrounding skin-lightening products (SLPs) among female medical students.

Therapeutic options for pediatric psoriasis are growing rapidly, with biologics and oral small molecules now playing a central role in modern treatment.

A recent systematic review of Merkel cell carcinoma (MCC) treatment in solid organ transplant (SOT) recipients reveals an urgent need for clearer treatment guidelines.

Cutaneous ulcers present a significant challenge in the management of chronic graft-versus-host disease (cGVHD), a complication that affects patients who have undergone allogeneic hematopoietic cell transplantation.

A recent nationwide study conducted in Italy provides important insights into how body weight may influence the efficacy of JAK inhibitors in treating moderate-to-severe atopic dermatitis (AD).

The growing body of research on the gut-skin axis and human microbiome has sparked increasing interest in microbiome-modulatory agents as potential treatments for acne vulgaris.

Dermoscopy traits of adnexal tumors in patients with darker skin tones may closely mimic features of malignant neoplasms, creating significant diagnostic uncertainty for clinicians.

Immune checkpoint inhibitors (ICIs) have transformed cancer care but can trigger immune-related adverse events such as psoriasis, complicating treatment decisions.

The use of beta-blockers has dramatically changed the management of infantile hemangiomas, with a significant increase in active treatment decisions at tertiary referral centers, according to a new retrospective cohort study.

A new international study has developed and validated prognostic models using novel inflammatory markers to predict in-hospital mortality in patients with drug reaction with eosinophilia and systemic symptoms (DRESS), a rare but life-threatening hypersensitivity reaction.

Gluten-related skin conditions may extend well beyond the classic dermatitis herpetiformis, according to a new overview of gluten-induced dermatoses that highlights diagnostic and therapeutic pathways for clinicians.

Climate change is severely affecting the physical and psychological health of reproductive-age women living in Bangladesh’s coastal communities, according to a new study.

Skin cancer risk remains high in patients with xeroderma pigmentosum, including rare long-term survivors, according to a newly reported case of squamous cell carcinoma (SCC) in a 55-year-old woman with the condition.

Primary care physicians are pivotal in the early recognition and referral of rare eosinophilic diseases, such as hypereosinophilic syndrome (HES) and eosinophilic granulomatosis with polyangiitis (EGPA), which remain underdiagnosed despite their serious multisystem impact.

A nationwide study of basal cell carcinoma (BCC) excisions in Denmark found that hospital-based specialists have significantly lower odds of incomplete removal than their practice-based peers, raising important questions about treatment setting and provider expertise.

Patients with autoimmune skin diseases (ASDs) may have improved survival following cancer treatment, according to a large population-based study, suggesting a possible immunologic advantage in oncologic outcomes.