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Shorter Telomeres Linked to Dangerous Blood Cell Mutations

September 2025

A major UK-based study has revealed a new link between ageing, DNA changes and the development of blood cancers….

Update on Riociguat for Patients with Sickle Cell Disease

This phase 1–2, randomised, double-blind, placebo-controlled trial enrolled 130 patients aged 18 or older with confirmed sickle cell disease.

CRISPR-Based Cell Therapy Eliminates Crises in Patients with Sickle Cell Disease

In a phase 3 trial involving 44 patients aged 12 to 35, exa-cel was found to provide remarkable results….

Venetoclax and Decitabine Improve Transplant Success in Older Patients with Leukaemia

A recent multicentre study has shown that venetoclax combined with decitabine as an effective first-line treatment for older patients with acute myeloid leukaemia.

Blood-Based Ageing Clock Shows Promise as a Clinical Tool

A groundbreaking study has developed a blood-based ageing clock capable of predicting biological age and providing insights into the ageing process…

Concizumab Shows Promise as a Subcutaneous Prophylaxis for Haemophilia A and B

A phase 3 clinical trial, explorer8, has demonstrated the efficacy and safety of concizumab…

Liberal Blood Transfusion Strategy Improves Neurological Outcomes in Acute Brain Injury Patients

A recent international clinical trial involving 850 patients has revealed that a liberal blood transfusion strategy significantly improves neurological outcomes…

Cell-Free DNA Identified as Early Relapse Predictor in B Cell Lymphoma

A ground-breaking study has identified circulating cell-free DNA as a potential biomarker for predicting early relapse in patients with aggressive B-cell lymphoma…

Itacitinib Improves Outcomes in Haploidentical Transplantation

A new study shows that adding itacitinib to standard GvHD prophylaxis in haplo-HCT is safe and well-tolerated.

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