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Inhaled Steroids Linked to Worsened Sickle Cell Disease Markers

November 2026

A 48-week randomised trial found that inhaled mometasone was associated with increased soluble VCAM-1 levels in adults with sickle cell disease without asthma, raising concerns about long-term treatment safety.

Inhaled Steroids Linked to Worsened Sickle Cell Disease Markers

A 48-week randomised trial found that inhaled mometasone was associated with increased soluble VCAM-1 levels in adults with sickle cell disease without asthma, raising concerns about long-term treatment safety.

multiple myeloma

T-cell engager Shows Early Activity in Relapsed Multiple Myeloma

An early MK-4002 trial identified a dose for further study in relapsed myeloma, alongside substantial toxicity.

Picture of a stethoscope

Quizartinib Linked to Improved AML Survival Outcomes

Quizartinib was associated with improved 1-year overall survival and higher remission rates than midostaurin in adults with newly diagnosed FLT3-ITD-positive acute myeloid leukaemia.

Maternal Haemoglobin Linked to Preterm Birth Risk

Maternal haemoglobin showed a U-shaped association with preterm birth, with risk thresholds varying throughout pregnancy and according to altitude.

3D Rendering of CAR T-Cell therapy in action.

High-Risk Multiple Myeloma Linked to Earlier CAR-T Cell Failure

A multicentre study of 598 patients with relapsed or refractory multiple myeloma identified distinct high-risk features associated with early and delayed treatment failure following cilta-cel.

Person testing genes for hematological processes and to test genetic variants in red blood cells

CRISPR Screens Reveal New Genes Regulating Red Blood Cell Density

CRISPR screens identified 17 genes and 13 genomic regions linked to red blood cell density, providing new insights into how genetic variants influence red blood cell traits.

SGLT2 Inhibitors Linked to Higher Haemoglobin and Haematocrit

A meta-analysis of 85 randomised clinical trials found that SGLT2 inhibitors were associated with modest increases in haemoglobin and haematocrit, alongside changes in erythropoietin and transferrin saturation.

pre-closure intraoperative fibrinogen

Pre-Closure Fibrinogen and Haemostasis in Spine Surgery

Pre-closure intraoperative fibrinogen has been associated with favourable early postoperative haemostasis in patients undergoing spinal deformity surgery.

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