Interventional Cardiology

In patients with post-stroke disability, all-cause mortality more than doubled (HR:2.18; 95% CI:1.84–2.60; p

In the absence of cardiomyocyte TGFB3, the study observed increased expression of profibrotic mediators including connective tissue growth factor (CTGF) and SERPINE1.

Endothelial Twist1 expression promoted plaque growth but simultaneously enhanced hallmarks of plaque stability, including increased collagen deposition and a greater number of ACTA2-positive smooth muscle–like cells.

Mortality occurred in 4.5% of patients in the sheath group versus 18.2% in the non-sheath group. Neurological outcomes also favoured preprocedural vascular sheath insertion.

Transcatheter aortic valve implantation results in a higher risk of mortality and stroke compared with surgical replacement, a 2026 systematic review has found.

A 518 patient randomised trial shows iron bioresorbable scaffold is noninferior to a contemporary drug eluting stent at 2 years, with comparable clinical outcomes.

STORM-PE shows that mechanical thrombectomy leads to greater early improvement in right ventricular function than anticoagulation alone in intermediate-high risk pulmonary embolism, without increased major adverse events.

When benchmarked against widely used risk scores, including APPLE, SUCCESS, PAT2C2H, HATCH, BASE-AF2, and CHA₂DS₂-VASc, the nomogram consistently demonstrated superior predictive performance.