Hematology

Nine-year data show sustained safety and reduced bleeding after gene therapy in haemophilia B, although enrichment for full viral capsids did not deliver clear clinical advantages.

A nursing-led remote evaluation enabled earlier prioritisation and improved multidisciplinary assessment for adolescents referred with heavy menstrual bleeding.

A real-world analysis suggests outpatient stem-cell mobilisation in multiple myeloma could safely reduce hospital admissions and bed use through risk stratification and machine learning prediction.

New findings reveal that B cell acute lymphoblastic leukaemia depends on intact beta catenin degradation, highlighting glycogen synthase kinase 3 beta inhibition as a potential therapeutic strategy.

A large paediatric cohort study shows that platelet processing and donor factors influence posttransfusion platelet increments and transfusion burden, without affecting hospital length of stay or mortality.

Parvovirus B19 was shown to infect haematopoietic stem cells, impairing self renewal and differentiation, with JAK2 STAT5 inhibition partially reversing virus induced bone marrow dysfunction.

Dasatinib plus blinatumomab demonstrated greater and sustained immune activation than ponatinib combinations in Ph+ acute lymphoblastic leukaemia, with marked effects on lymphocytes and natural killer cells.

Early haematopoietic stem cell transplantation after liver transplantation resulted in 90% survival in children with hepatitis-associated aplastic anaemia, with normal blood counts and liver function at follow up.