The Effect of Vestibular Rehabilitation in the Management of Vestibular Migraine in Adults: A Systematic Review and Meta-Analysis - European Medical Journal

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The Effect of Vestibular Rehabilitation in the Management of Vestibular Migraine in Adults: A Systematic Review and Meta-Analysis

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Neurology
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Authors:
* Bradley Ong , 1 Jad El Ahdab , 2 Marina Vilardo , 3 Nicolas R. Thompson , 4 Neil Nero , 5 Ahmet Günkan , 6 Neil Cherian , 7 Julia Bucklan 7
  • 1. Sleep Disorders Center, Neurological Institute, Cleveland, Ohio, USA
  • 2. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
  • 3. Department of Neurology, Neurological Institute, Cleveland Clinic, Ohio, USA
  • 4. Neurological Institute Center for Outcomes, Research, and Evaluation (NI-CORE), Cleveland Clinic, Ohio, USA
  • 5. Education Institute, Floyd D. Loop Alumni Library, Cleveland Clinic, Ohio, USA
  • 6. Division of Vascular and Interventional Radiology, Department of Radiology and Imaging Sciences, University of Arizona, Tucson, USA
  • 7. Center for Neurological Restoration, Cleveland Clinic, Ohio, USA
*Correspondence to [email protected]
Disclosure:

The institution of Ong has received research support from the American Academy of Neurology (AAN) and the American Headache Society. Ong has a non-compensated relationship as an Editorial Board Member with the Neurology Resident & Fellow Section that is relevant to AAN interests or activities; and a non-compensated relationship as a contributor with Neurology Minute that is relevant to AAN interests or activities. The other authors have declared no conflicts of interest.

Citation:
Neurol AMJ. ;3[1]:36-38. https://doi.org/10.33590/neurolamj/3N0EKA4N.
Keywords:
Dizziness handicap inventory, meta-analysis, systematic review, vestibular migraine, vestibular rehabilitation.

Each article is made available under the terms of the Creative Commons Attribution-Non Commercial 4.0 License.

BACKGROUND AND AIMS

Vestibular migraine (VM) is a common migraine subtype characterized by recurrent vestibular symptoms. Despite its prevalence, evidence-based treatment guidelines are lacking.1-4 Vestibular rehabilitation (VR) has been proven effective in many vestibular disorders, but its role in managing VM has not been well established.5 This systematic review aimed to summarize and pool the evidence on the effectiveness of VR for VM using standardized outcome measures, primarily focusing on patient reported dizziness-related quality-of-life assessments.

MATERIALS AND METHODS

The authors systematically searched MEDLINE, Embase, Cochrane Library, and Scopus from inception to March 2025. Studies were eligible if they enrolled adults with vestibular migraine diagnosed using recognized criteria and reported at least one relevant clinical outcome after a clearly described VR intervention. Meta-analysis of mean change in Dizziness Handicap Inventory (DHI) scores was performed. Risk of bias was assessed using the Cochrane RoB 2 tool for RCTs and the ROBINS-I tool for observational studies.

RESULTS

Seven studies comprising 413 patients (mean age: 45.4; 76% female) with VM treated with VR were included. The effect of vestibular rehabilitation on DHI scores showed a pooled mean difference of −29.3 (95% CI: −40.2–−18.3), more than the clinically important difference of 18 points (Figure 1). However, the authors’ meta-analysis had high heterogeneity.

Figure 1: Forest plot of change in DHI scores using a 0.5 correlation assumption.
DHI: Dizziness Handicap Inventory; MD: mean difference; VR: vestibular rehabilitation.

Across studies, the most commonly used rehabilitation elements were habituation exercises, adaptation training, gaze stabilization, balance training, and gait training. Programs ranged from 4 weeks to about 30 weeks, and some were supervised in clinic whereas others relied largely on home exercise programs with remote follow-up.

This variability is clinically relevant because vestibular rehabilitation is often discussed as a single intervention when, in practice, it encompasses multiple distinct treatment strategies.

CONCLUSION

VR demonstrated a reduction in DHI scores, meeting the clinically significant difference of 18, indicating clinical improvement.13 However, the considerable heterogeneity limits the generalizability of these results. Despite these limitations, the authors’ findings support VR as a promising nonpharmacologic option for vestibular migraine, particularly for reducing dizziness-related disability, while also underscoring the need for better-designed randomized studies. Future trials should standardize diagnostic criteria, define VR protocols more clearly, account for concomitant preventive therapy, incorporate objective balance measures, and evaluate durability of response over longer follow-up.

References
Ong B et al. The effect of vestibular rehabilitation in the management of vestibular migraine in adults: a systematic review and meta-analysis. Abstract 15-0101. AAN Annual Meeting, April 18-22, 2026. Lempert T et al. Vestibular migraine: diagnostic criteria. J Vestib Res. 2022;32(1):1-6. Beh SC et al. The spectrum of vestibular migraine: clinical features, triggers, and examination findings. Headache. 2019;59(5):727-40. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1-211. Villar-Martinez MD, Goadsby PJ. Vestibular migraine: an update. Curr Opin Neurol. 2024;37(3):252-63. Aydin İ et al. Effects of vestibular rehabilitation and pharmacological therapy in patients with vestibular migraine. Neurol Sci Neurophys. 2020;37(3):110-7. Balci B, Akdal G. Outcome of vestibular rehabilitation in vestibular migraine. J Neurol. 2022;269(12):6246-53. Illarionova ЕМ, Gribova NP. Vestibular rehabilitation in vestibular migraine. Bull Rehabil Med. 2021;20(5):47-52. Vitkovic J et al. Vestibular rehabilitation outcomes in patients with and without vestibular migraine. J Neurol. 2013;260(12):3039-48. Koc A, Cevizci Akkılıc E. Effects of vestibular rehabilitation in the management of patients with and without vestibular migraine. Braz J Otorhinolaryngol. 2022;88:S25-33. Liu L et al. Effect of vestibular rehabilitation on spontaneous brain activity in patients with vestibular migraine: a resting-state functional magnetic resonance imaging study. Front Hum Neurosci. 2020;14:227. Stancel-Lewis J et al. Vestibular rehabilitation therapy for the treatment of vestibular migraine, and the impact of traumatic brain injury on outcome: a retrospective study. Otol Neurotol. 2022;43(3):359-67. El Ahdab J et al. The effect of vestibular rehabilitation in the management of vestibular migraine in adults: a systematic review and meta-analysis. Headache. 2026;66(1):77-87.

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