LASERS and energy-based devices may target cellular senescence, potentially rejuvenating aging skin at a fundamental molecular level.
Understanding Cellular Senescence in Skin Aging
Cellular senescence is a hallmark of skin aging characterized by cell cycle arrest, altered secretory activity, and disrupted tissue homeostasis. This systematic review evaluated whether dermatologic technologies can modulate these senescent pathways. Following PRISMA guidelines, the authors identified 23 articles examining lasers and other energy-based devices in relation to skin aging.
The studies spanned laser modalities, light-based therapies, radiofrequency, ultrasound, photobiomodulation, photodynamic therapy, and intense pulsed light. Despite heterogeneity in protocols and endpoints, most reports showed a reduction in markers associated with cellular senescence with parallel improvements in age-related skin changes. Several studies also suggested a role in minimizing neocarcinogenesis, supporting the idea that altering senescent signaling may influence oncologic risk.
How Lasers And Energy-Based Devices May Influence Senescence
Across the included studies, lasers and energy-based devices appeared to restore more youthful patterns of cellular signaling in treated skin. Treatment was associated with changes consistent with reduced senescence, including improved cell function and evidence of skin rejuvenation at microscopic and clinical levels. These findings support the concept that controlled, low level stress from these modalities can induce hormesis, promoting resilience rather than damage in aging tissue.
The review authors propose that hormesis may represent a converging mechanism through which different energy-based approaches enhance skin anti-fragility and longevity. While specific parameters varied, the overall signal suggests that laser therapy and related technologies could form part of a strategy to target cellular senescence in dermatologic practice.
Clinical Implications and Research Gaps
For clinicians, these data highlight the potential for lasers and other energy-based devices to do more than resurface or tighten the skin. By acting on cellular senescence, these treatments may contribute to longer term improvements in skin structure and function. However, the current evidence base is limited, and most studies are small, with variable endpoints and follow up durations.
The authors emphasize the need for larger, standardized trials that correlate changes in senescence markers with durable clinical outcomes. Future work should clarify optimal treatment parameters, patient selection, and safety considerations when targeting senescence in skin aging. Until then, clinicians should interpret the benefits of these modalities within the context of individual patient goals, existing evidence for skin rejuvenation, and the evolving science of cellular senescence.
Reference: Kelm RC et al. The Impact of Lasers and Energy-Based Devices on Cellular Senescence: A Systematic Review. Lasers Surg Med. 2025;doi:10.1002/lsm.70079.
