Tools, Trials, and Treatments: Navigating RCC in Real Life - European Medical Journal

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Tools, Trials, and Treatments: Navigating RCC in Real Life

This podcast was initiated, funded and approved by GSK and is intended for healthcare professionals only.

The views and opinions expressed in this podcast are those of the individual speakers and do not necessarily reflect those of GSK or EMJ. The speakers have received honoraria for their participation in this recording.

Episode 3: Tools, Trials, and Treatments: Navigating RCC in Real Life

In the final podcast of this three-part series, we hear expert insights into evolving guidelines, practical tools, and multidisciplinary collaboration for the optimal diagnosis and management of RCC.

Explore how healthcare professionals navigate RCC in daily practice, including the latest guidelines to the streamlining of referral pathways and evaluating treatment response.

Speakers

Anju Peters1

Surinder Birring2

Kevin Gruffyd-Jones3

1. Northwestern University Feinberg School of Medicine, Chicago, IL, USA
2. Lead for specialist Cough Clinic, King’s College Hospital, London, UK
3. General practitioner, Box, Wiltshire, UK

References

  1. Ringus DL et al. Management and referral patterns for new-onset chronic cough in primary care patients. Allergy Asthma Proc. 2022;43(6):e72-9.
  2. Lim GK et al. Knowledge and perceptions of refractory chronic cough: a survey of US healthcare professionals. Abstract 2030749. CHEST Annual Meeting, 19-22 October, 2025.
  3. Lim GK et al. What’s in a name? confusion around refractory chronic cough among US healthcare professionals. Poster PA3587. ERS Congress, 27 September-1 October, 2025.
  4. Irwin RS et al. Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines. Chest. 2006;129(1 Suppl):1S-23S.
  5. Parker SM et al. British Thoracic Society clinical statement on chronic cough in adults. Thorax. 2023;78(Suppl 6):s3-19.
  6. Irwin RS et al. Chronic persistent cough in the adult: the spectrum and frequency of causes and successful outcome of specific therapy. Am Rev Respir Dis. 1981;123(4 Pt 1):413-7.
  7. Irwin RS et al. Cough. A comprehensive review. Arch Intern Med. 1977;137(9):1186-91.
  8. Irwin RS, Madison JM. Anatomical diagnostic protocol in evaluating chronic cough with specific reference to gastroesophageal reflux disease. Am J Med. 2000;108 Suppl 4a:126S-130S.
  9. Chung KF, Mazzone SB, Chronic cough hypersensitivity as a neuropathic disorder: implications for management and new treatments. Annu Rev Med. 2025;DOI: 10.1146/annurev-med-050224-124414.
  10. Morice AH et al. ERS guidelines on the diagnosis and treatment of chronic cough in adults and children. Eur Respir J. 2020;55(1):1901136.
  11. Chung KF et al. Chronic cough as a disease: implications for practice, research, and health care. Lancet Respir Med. 2025;13(2):110-2.
  12. Scott B. The significance and psychosocial burden of refractory chronic cough: interview with two key opinion leaders and a patient. EMJ Respir. 2025;13[Suppl 1]:2-11.
  13. Bali V et al. Chronic cough: more than just a persistent cough: a systematic literature review to understand the impact of chronic cough on quality of life. Qual Life Res. 2024;33(4):903-16.
  14. Chung KF et al. Cough hypersensitivity and chronic cough. Nat Rev Dis Primers. 2022;8(1):45.
  15. Hirons B et al. The development of the Cough Hypersensitivity Questionnaire for chronic cough. ERJ Open Res. 2024;10(6):00468-2024.
  16. Kousar L et al. The Sensations Provoking Cough: The ToPiC Questionnaire [abstract]. Am J Respir Crit Care Med. 2022;205:A2811.
  17. Morice AH et al. Cough hypersensitivity syndrome: a distinct clinical entity. Lung. 2011;189(1):73-9.
  18. French CT et al. Evaluation of a cough-specific quality-of-life questionnaire. Chest. 2002;121(4):1123-31.
  19. Boulet LP et al. Tools for assessing outcomes in studies of chronic cough: CHEST guideline and expert panel report. Chest. 2015;147(3):804-14.
  20. Morice AH et al. A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response. Eur Respir J. 2014;44(5):1149-55.
  21. Birring SS et al. Obstructive sleep apnoea: a cause of chronic cough. Cough. 2007;3:7.
  22. Palones E et al. Clinical and functional characteristics, possible causes, and impact of chronic cough in patients with cerebellar ataxia, neuropathy, and bilateral vestibular areflexia syndrome (CANVAS). J Neurol. 2024;271(3):1204-12.
  23. Varney VA et al. Longstanding tracheobronchomalacia: a forgotten cause of severe cough and its response to roflumilast. Respir Med Case Rep. 2020;31:101247.
  24. Marucci G et al. Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications. Expert Opin Ther Pat. 2019;29(12):943-63.
  25. Richards D et al. Action of MK-7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation. Br J Pharmacol. 2019;176(13):2279-91.
  26. Garceau D, Chauret N. BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration. Pulm Pharmacol Ther. 2019;56:56-62.
  27. Nguyen AM et al. Leicester Cough Questionnaire validation and clinically important thresholds for change in refractory or unexplained chronic cough. Ther Adv Respir Dis. 2022;16:17534666221099737.

NX-GBL-CML-WCNT-250011 – January 2026

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