This podcast is funded by Finapres Medical Systems.
The views and opinions expressed in this podcast are those of the individual interviewees and do not necessarily reflect those of Finapres Medical Systems or EMJ.
Episode 1: When Low Blood Pressure Makes Life Difficult
In this episode, Satish Raj and Gert van Dijk explore the diagnosis, clinical burden, and management of orthostatic hypotension. The discussion examines how low blood pressure affects daily functioning, the importance of accurate diagnosis, and current treatment approaches.
Key Discussion Themes
- Definitions and subtypes of orthostatic hypotension
- Differential diagnosis and the role of tilt-table testing
- Impact on quality of life and daily functioning
- Current treatment landscape and clinical guidelines
- Unmet needs and future research priorities
Speakers:
Satish Raj1
Gert van Dijk2
1. University of Calgary Cumming School of Medicine, Alberta, Canada; Vanderbilt University Medical Center, Nashville, Tennessee, USA
2. University Medical Center, Nashville, Tennessee, USA
Episode 2: Haemodynamic Instability and Spinal Cord Injury
In this episode, Aaron Phillips discusses haemodynamic instability following spinal cord injury, with particular focus on autonomic dysreflexia. The conversation reviews the neuronal mechanisms underpinning autonomic dysfunction, the clinical burden of hypertensive and hypotensive complications, and current management strategies. The episode also explores emerging therapeutic approaches, including the development and evaluation of implantable systems designed to restore haemodynamic stability.
Key Discussion Themes
- Definition and clinical features of haemodynamic instability
- Autonomic dysreflexia: mechanisms and patient impact
- Chronic hypertensive and hypotensive complications
Speaker:
Aaron Phillips3
3. University of Calgary Cumming School of Medicine, Alberta, Canada
Episode 3: Orthostatic Hypotension in Parkinson’s Disease
In the final episode of the series, David Goldstein examines orthostatic hypotension as a manifestation of autonomic failure in Parkinson’s disease. The discussion explores the pathophysiology of cardiac noradrenergic deficiency, its identification and clinical implications, and current management approaches. The episode also considers the prognostic significance of orthostatic hypotension in Parkinson’s disease and potential future directions in research and patient care.
Key Discussion Themes
- Autonomic failure in Parkinson’s disease
- Cardiac noradrenergic deficiency: definition and identification
- Clinical consequences, including falls and cognitive impairment
- Mechanistic insights into sympathetic denervation
- Current treatment approaches and guideline considerations
- Future research priorities
Speaker:
David Goldstein4
4. The Autonomic and Catecholamine Healthspan Institute, LLC, Potomac, Maryland, USA
