News

Systemic lupus erythematosus is entering a new therapeutic era as precision immunotherapy strategies target disease-driving immune mechanisms with increasing specificity and potential durability.

Oral migraine preventives reduced headache burden in real world care, but tolerability varied sharply across commonly used drugs.

Pulmonary nodule evaluation on CT scans may be significantly enhanced through artificial intelligence, as a transformer-based model demonstrates strong diagnostic performance and clinical utility in a multi-reader, multi-case trial.

Infection-related mortality after HSCT was driven by resistant bloodstream infections and invasive aspergillosis.

Environmental and lifestyle exposures significantly influence acne development through complex biological and social mechanisms.

Physical activity is now recommended as standard care in arthritis, with new guidance emphasizing behavior change and reduced sedentary time.

Cleft palate was linked to the highest rates of psychological and neurodevelopmental disorders across cleft subtypes.

Delayed surgery in internal hernia related bowel obstruction was linked to more bowel necrosis and resection.

Respiratory viral infections may increase lung cancer risk and accelerate tumor growth through lasting immune changes.

Migraine prevention improved at 3 months in a real world study comparing galcanezumab with oral therapies. Read more.

Preoperative breast cancer screening before chest masculinization surgery helped identify malignancy and improve surgical planning.

Psychopharmacology is emerging as a critical tool in dermatology, with growing evidence supporting its role in managing both skin conditions and associated psychiatric disorders.

Breastfeeding for at least four months was linked to lower asthma and IgE sensitization into young adulthood.

Antibiotic use near the end of life often offers limited symptom relief while increasing treatment burden.

Hormonal transitions across the lifespan may reshape sex differences in Sjogren’s disease risk and prevalence patterns.

CAR-T therapy improved mobility and stiffness in stiff person syndrome in a pivotal Phase II study.

Adults responsible for household food decisions often found ultra-processed foods confusing, despite linking them with poor health.

Acupuncture for chemotherapy-induced nausea and vomiting in breast cancer is now set for a broader comparative review.

Higher alcohol consumption is linked to increased risk of early small airway obstruction in adults.

Ulixacaltamide maintained response in essential tremor in a Phase III randomized withdrawal study at AAN 2026.

Gonococcal endocarditis may present as aggressive, culture-negative infection with embolic complications and severe valvular destruction.

Rapid whole genome sequencing delivered likely genetic diagnoses in nearly one quarter of hospitalized adults with unexplained neurologic symptoms.

Higher ultra-processed food intake was linked to greater thigh muscle fat on MRI in at-risk adults.

AI tools may help consumers identify skin conditions more accurately, but guidance on next steps still needs improvement.

A reasoning-based language model matched GPT 4.1 in predicting 90-day stroke disability from discharge notes.

Collaborative care helped a patient with opioid use disorder, advanced cancer, and housing instability complete treatment.

New IBS research highlights persistent pain treatment gaps and points to peripheral nerve targets for future, safer therapies.

Intersectional discrimination may reduce HIV viral suppression by increasing stimulant and tobacco use among sexual minoritized men.

Smoking emerged as the strongest modifiable driver of esophageal squamous cell carcinoma in a large Johannesburg analysis.

Ketamine showed moderate efficacy in super-refractory status epilepticus, with EEG and inflammatory markers linked to response.

COPD in never-smokers showed more symptoms and type 2 inflammation, pointing to a distinct clinical phenotype.

Vitiligo stigma varies across cultures, but its psychological toll is global, severe, and too often underestimated.

Infectious disease forecastability varied by season, pathogen, and population size, shaping how well hospital admissions were predicted.

Early lung function decline may help predict progression in patients at risk of systemic sclerosis, according to new longitudinal data.

Health care barriers were linked to lower cancer screening adherence across five major cancer types.

Parenteral clomipramine showed no clear early advantage over oral therapy for depression, while evidence in OCD remained limited.

Gut microbiome shifts may help drive atherosclerosis and peripheral artery disease through inflammatory and metabolic pathways.

Bronchiectasis may silently increase risk of non-tuberculous mycobacteria infection, according to new genetic evidence.

Cosmetic adverse reactions may cause lasting skin damage, especially in younger patients and those with allergy histories.

Adult IgA vasculitis may carry greater renal and gastrointestinal risks. Read more about diagnosis and management.

Cancer care in humanitarian settings remains fragmented, underprioritized, and urgently in need of cross-border policy solutions.

Inflammation and malnutrition may work together to worsen outcomes in acute ischemic stroke.

Cholera remains rare in travelers, but risk rises with unsafe water, outbreak exposure, and delayed treatment.

Parkinsonism trends in the UK reveal falling PD incidence, rising prevalence, and increasing recognition of vascular Parkinsonism..

A case report explores whether mRNA COVID-19 vaccination may coincide with hematopoietic malignancy and possible mechanisms.

A new review of respiratory mechanics modeling highlights how advanced measurement techniques could improve the diagnosis and monitoring of respiratory diseases including asthma and COPD.

A new skin cancer risk stratification tool for solid organ transplant recipients shows strong international validation but inconsistent clinical adoption.

Latent tuberculosis infection was common in type 2 diabetes, with poor glycemic control linked to higher risk.

Whole-body cryotherapy significantly improves pain, function, and disease activity in patients with ankylosing spondylitis, a new meta-analysis finds.

Next-generation sequencing use rose in advanced cancer, but access remained uneven across socioeconomic, racial, and insurance groups.

Navigated transcranial magnetic stimulation improved PTSD outcomes when added to intensive residential therapy for combat-related symptoms.

A new registry study reveals human metapneumovirus causes severe illness in blood cancer patients worldwide.

HIV preexposure prophylaxis uptake remained low among US youths, with disparities by age, sex, region, and policy.

Gout inflammation may follow a timed molecular sequence that opens distinct therapeutic windows for phase-specific treatment.

Truncal acne may require more tailored treatment because truncal skin differs structurally and functionally from facial skin.

Advanced practice nurse involvement improved PREEMPT interval adherence for chronic migraine patients receiving onabotulinumtoxinA in routine care.

Risk-reducing surgery decisions were shaped most by ovarian cancer risk and menopausal symptoms in premenopausal women.

Yogurt can be introduced from 6 months, offering nutrients and live cultures that support infant health.

Mycoplasma pneumoniae infection in children may lead to plastic bronchitis, with new predictors aiding early detection.

Many ADHD care providers for children report school coordination gaps, with training and barriers shaping support.

A mobile nutrition app improved dietary moderation and appetite loss outcomes in patients with cancer over 4 weeks.

A qualitative study suggests hospital crisis decision-making can sideline routine care, while strengthening preparedness for later emergencies.

Lupus nephritis biomarkers remain a major area of interest, but few currently show enough evidence to reflect kidney histopathology and support clinical use.

Hospital-acquired pneumonia remains a lethal ICU threat, but its diagnosis and management are entering a more precise era.

Deucravacitinib showed strong short-term psoriasis responses and excellent scalp clearance in real-world clinical practice.

CART cell therapy was linked to early hemostatic shifts that may help predict toxicity and bleeding risk.

Brief virtual therapy for anxiety in pregnancy was feasible, well accepted, and linked to reduced symptoms.

Longitudinal sampling for sexually transmitted enteric infections appeared feasible among GBMSM attending sexual health services.

Severe childhood asthma continues to cause major morbidity in low- and middle-income countries despite its low prevalence.

Cell-free secretome therapy restored hair growth in preclinical androgenic alopecia models by protecting papilla cells.

Rheumatoid arthritis risk criteria may help identify which patients with arthralgia are most likely to progress.

Patients with severe alopecia areata treated with upadacitinib achieved greater hair regrowth at Week 24 versus placebo.

Male breast cancer risk stratification may help identify which patients with luminal early disease benefit from chemotherapy.

Stroke trunk control in acute ischemic stroke may be closely linked to resting posterior trunk muscle tone and stiffness.

Patients with moderate-to-severe atopic dermatitis showed generally low long-term upadacitinib safety event rates across ages.

Youth advisory boards in HIV research remain under-evaluated, despite shaping study planning, implementation, and community engagement.

Continuous secukinumab treatment showed sustained hidradenitis suppurativa lesion control through 4 years in responding patients.

Nirsevimab was linked to fewer RSV hospitalizations and severe neonatal outcomes than maternal RSVpreF vaccination in France.

Remibrutinib improved itch and hive severity within 12 hours in chronic spontaneous urticaria in Phase III analysis.

Cerebral lymphatic dysfunction is emerging as a promising therapeutic target in Alzheimer’s disease treatment and research.

Smart control of CAR T cells is advancing cancer immunotherapy by improving precision, safety, and adaptability.

A nationwide cohort study found high in-hospital mortality among adults receiving ECMO, with risk shaped by age and comorbidity

Serum sickness after botulinum toxin type A may signal a rare delayed systemic immune reaction. Read more.

A deadly meningitis outbreak in the U.K. has renewed focus on vaccination, early treatment, and outbreak prevention.

Long-term secukinumab treatment preserved bone structure and controlled disease activity in psoriatic arthritis over 48 months.

Regional nodal irradiation in breast cancer showed low recurrence rates after nodal pCR, even when residual breast disease remained.

Migraine often becomes more frequent, severe, and harder to manage during the menopause transition in midlife women.

Obstructive sleep apnea affected nearly half of never-smokers with newly diagnosed lung cancer in this prospective study.

Metaverse based infectious disease training improved engagement and self-directed learning for school nurses in this qualitative study.

Nanotechnology therapeutics may improve autoimmune disease treatment by enhancing targeting, lowering toxicity, and enabling immune modulation.

Microneedle patches may improve hyperpigmentation treatment by enhancing skin delivery, efficacy, and tolerability of active agents.

Psychological interventions for parents in pediatric palliative care improved short term mental health outcomes.

Practical judgment in aging was linked to scam engagement and brain connectivity in older adults without dementia.

AI-powered tumor immunity mapping is helping refine mRNA vaccine design for more precise and personalized cancer immunotherapy.

Osteopathic manipulative treatment may offer a new way to support pulmonary function in asthma. Read more.

A nurse-led bladder management approach improved bladder volume reproducibility and reduced repeat imaging in prostate hypofractionated radiotherapy.

Recent infection was associated with higher cryptogenic ischemic stroke odds in younger adults and linked biomarker changes.

COPD breathlessness action plans may help patients manage episodes, reduce anxiety, and avoid emergency care. Read more.

Definisse KP1 eye contour cream may enhance eye rejuvenation when combined with onabotulinum toxin A. Read more.

Meningitis cases linked to a deadly UK outbreak have risen to 20, prompting expanded antibiotics and vaccination measures.

Sjögren’s disease linked to higher cancer risk in patients and close relatives in this cohort study.

Prostate biopsy under local anesthesia showed similar safety and detection outcomes, with better comfort trends for transperineal sampling.

Antiseizure medication shortages were linked to more seizure-related emergency visits and seizure clusters among adults with epilepsy.

Obstructive sleep apnea syndrome may be linked to oxidative stress, according to a Mendelian randomization study.

Measles resurgence reinforces that the two dose MMR vaccine remains the strongest defense against severe disease.

Gout biomarkers linked to lipids, amino acids, and genes may help refine future therapeutic targeting. Read more.

Fractional CO2 laser improved post-acne scars more than microneedling radiofrequency, but with greater pain and downtime.

Narrative-based palliative care reduced stress and improved quality of life in elderly terminal cancer patients and families.

Restorative neurostimulation improved pain, disability, and quality of life in patients with refractory chronic low back pain.

Saliva molecular testing showed high accuracy for pulmonary tuberculosis, clearly outperforming oral swabs in a prospective study.

Idiopathic pulmonary fibrosis progression may begin nearly a decade before symptoms, according to new modeling research.

Older adults with frailty often faced prolonged functional recovery and unmet care needs after major elective noncardiac surgery.

Hearing loss in mild cognitive impairment was common, but objective hearing measures did not differ significantly from controls.

RSV in older adults remains underrecognized, with policy gaps limiting surveillance, vaccination, and prevention across Europe.

Nerandomilast reduced lung inflammation and fibrosis in IIM-ILD preclinical models. Read more to find out what this means for the future.

Delgocitinib cream significantly improved quality of life in adults with moderate to severe Chronic Hand Eczema (CHE) in pooled phase III trial data.

Sustainable breast cancer surgery was feasible in a pilot study, with high sentinel node detection rates preserved.

Topiramate prophylaxis was linked to reduced cluster headache pain and disability in adults across this prospective cohort.

Ixekizumab achieved high clinical response rates in children with juvenile idiopathic arthritis in a Phase III trial.

Among Gen Z college students, HPV vaccination intention was driven more by vaccine perceptions than emotional flow.

STEM cell therapy is emerging as a promising approach for silicosis, an irreversible fibrotic lung disease caused by chronic exposure to respirable crystalline silica.

Abrocitinib appears durable and well tolerated in patients with moderate-to-severe atopic dermatitis (AD), also known as eczema, according to a 2-year retrospective real-world study.

A new transition success score for pediatric rheumatology patients provides a structured method to evaluate outcomes when adolescents move from pediatric to adult care.

Adaptive artificial intelligence may reshape neuroplasticity, raising concern that cognitive autonomy could be gradually compromised.

A new review has highlighted the gut microbiota as a potential systemic driver of liver metastasis in small cell lung cancer, shifting attention beyond tumor genetics alone to the gut liver axis.

Gut mucosal immunity may be strengthened by Clostridium butyricum, shaping antiviral defense and inflammatory control through microbial metabolites.

Higher cardiorespiratory fitness linked to lower COVID-19 hospitalization risk, but not SARS-CoV-2 infection, in a large population cohort.

Radiologic exposomics may help reveal how environmental exposures shape cancer biology through imaging biomarkers.

A faith-based education program markedly improved recombinant zoster vaccine knowledge and intent in vulnerable adults.

Pompe disease management is evolving as next-generation enzyme replacement, gene therapy, and digital monitoring reshape decisions.

Obesity hypoventilation syndrome treatment improved as acetazolamide with atomoxetine reduced mean CO2 and AHI, raising saturation.

Exercise was associated with reduced cancer-related lymphedema risk, with meta-analysis showing a 29.0% relative reduction overall.

Pazopanib shows activity and manageable safety in paclitaxel-pretreated cutaneous angiosarcoma, offering a potential second-line therapy option.

A remote physical activity intervention improved functional fitness in Alzheimer’s dyads despite unchanged daily MVPA overall.

Manual acupuncture alleviates rheumatoid arthritis pain by targeting the spinal microglia via NF-κB/STAT3.

IDSA guidelines recommend RSV vaccination for immunocompromised adults, and advise individualized timing plus shared decisions now.

A mouse long COVID model associates breathlessness with postinfectious fibrotic lung remodeling and neuroinflammation following clearance.

Patch testing in hand and foot eczema frequently showed no allergen, yet potassium dichromate topped positive results overall here.

Respiratory biologics were prescribed to few eligible adults with asthma and obesity, yet reduced exacerbations significantly.

Cancer after cardiac surgery was tied to shorter long-term survival, even though in-hospital mortality remained low.

Former American football players showed poorer cognitive and neuropsychiatric function, with symptoms worsening by exposure level.

COVID-19 vaccination is strongly recommended for immunocompromised patients for the 2025–2026 season, according to new guidance.

Statewide Texas survey data link indoor ventilation and smoking to higher adult asthma morbidity from 2019–2022.

Transplant oncology is expanding liver transplantation for some cancers pairing downstaging therapy with strict selection criteria.

In cervical dystonia botulinum neurotoxin injections improved sleep quality but did not ease anxiety or depression in adult cohort.

Uncomplicated UTIs disrupt lives as recurrence and antimicrobial resistance complicate antibiotic choice for clinicians’ daily care.

Sleep apnea specific hypoxic burden predicted higher 30-day postoperative mortality and cardiac complications after major surgery.

Analysis finds 2030 skin-related neglected tropical diseases milestones off track as DALYs increase heterogeneously across nations.

Large vessel vasculitis may present as leg pain, and FDG-PET/CT uncovered lower extremity predominant disease in 16 patients today.

Cervical cancer screening disparities persist for African-immigrant women in the United States, highlighting barriers and care-gaps.

Frequent dancing was linked to substantially lower dementia risk in older adults followed for two decades.

A mobile instant messaging exercise-program did not significantly improve lab-verified smoking-cessation overall rates at 6 months.

Long-acting injectable antiretroviral therapy may ease pill burden, improve adherence, and privacy in Pakistan, interviews suggest.

Large language models in glaucoma show promise for education and decision support, yet performance varies widely.

In outpatient axial spondyloarthritis care, radiographic hip involvement affected 13.90% and aligned with greater severity overall.

Nordic data link gastric bypass to rare, excluded stomach cancer, with risk rising after 10 years and diagnosis potentially delayed.

A recently published case study suggests life story narration in bipolar disorder can solidify with time, into a coherent, emotion shaped worldview.

Mpox-HIV coinfection in MSM was linked to more severe symptoms and higher hospitalization, in Hangzhou case series of 104 patients.

Pediatric obstructive sleep apnea raised influenza and COVID-19 diagnoses over five years in a U.S. TriNetX large EHR cohort study.

Prior cesarean delivery was linked to higher postmolar gestational trophoblastic neoplasia risk, without increased chemoresistance overall.