The publication of this infographic was funded by Boehringer Ingelheim. This content is intended for US Healthcare Professionals.
Explore the HER2 blueprint and what “activating” really means. This infographic highlights how HER2 activating mutations can occur anywhere in the receptor and, regardless of location, can dysregulate receptor signaling and drive oncogenesis.
Learn:
- What are the three key domains of the HER2 receptor, and what distinct role does each play in receptor function?
- Where in the receptor can HER2 activating mutations occur?
- How can mutations in the ECD, TMD, and TKD each promote an active receptor state?
- What are the consequences when HER2 activating mutations induce constitutive, ligand-independent TKD activation?
