VESTIBULAR dysfunction and impaired balance may be more common in patients with primary Sjogren’s syndrome than previously understood, according to new research exploring the condition’s neurological impact. This observational study offers a fresh perspective on the systemic effects of this chronic autoimmune disease, highlighting its potential influence on both peripheral and central vestibular function.
Researchers evaluated 24 patients diagnosed with primary Sjogren’s syndrome alongside 26 sex-matched healthy controls to assess differences in vestibular and balance performance. A comprehensive battery of diagnostic tests, including gaze, saccade, tracking, optokinetic, video head impulse, and sensory organization tests, was used to measure both central and peripheral vestibular integrity.
The results revealed significant impairments among the Sjogren’s group, particularly in video head impulse testing and sensory organization testing. These deficits suggest a broader neurosensory component to the disease that may contribute to functional balance issues and increased fall risk. The impairments in vestibular function could explain symptoms such as dizziness or unsteadiness, which are not traditionally considered core manifestations of Sjogren’s syndrome but may be underreported or underdiagnosed.
The study emphasizes the importance of incorporating vestibular assessments into the routine evaluation and long-term follow-up of patients with primary Sjogren’s syndrome. Addressing these symptoms may improve patients’ overall stability, daily functioning, and quality of life.
Given that Sjogren’s syndrome most frequently affects middle-aged women, the findings underscore the need for clinicians to monitor for signs of balance disturbance that might otherwise be attributed to aging or unrelated causes. Future research may clarify whether vestibular rehabilitation or other interventions could help mitigate these challenges.
Reference:
Turan M et al. A new perspective on primary Sjogren’s syndrome: investigation of vestibular and balance functions. J Laryngol Otol. 2025:1-6. [Online ahead of print]
