Microbiology & Infectious Diseases

A phase 2 trial in Gabon showed that the PfSPZ malaria vaccine is safe in children aged 1–12 years but failed to prevent Plasmodium falciparum infection.

Immune profiles after COVID-19 vaccination predict booster need, with rapid-decliners at higher risk of breakthrough infection.

Rare genetic variants affecting antiviral, inflammatory, and autophagy pathways may explain severe neurological complications from chickenpox in children.

A landmark trial combining novel therapies has produced the first signs of durable post-treatment HIV control, pointing to a new frontier in functional cure research.

Prior dengue infection reshapes innate immunity, boosting vaccine efficacy. Vaccination alone fails to replicate these immune changes.

Global disparities in AMR governance show high-income countries with stronger plans, while low-income nations face weaker strategies and higher infection burdens.

A 3-month clofazimine- and rifapentine-containing regimen for drug-susceptible TB failed to improve cure rates and caused more severe adverse events than standard therapy, according to the Clo-Fast trial.

New UKHSA data show pre-school booster coverage has fallen to 81.4% in England, below herd immunity thresholds, leaving children vulnerable to outbreaks.