Neurology

The identification of pathological elements that drive disease progression, so-called regulators, is essential when studying progressive diseases.

In glioblastoma (GB), patients’ reliable response assessment criteria are crucial in order to accurately compare the responsiveness of different therapies in clinical trials, and to differentiate between therapy-induced changes and true tumour progression.

Brain tumour-related epilepsy (BTRE) is associated with diffuse lower-grade gliomas (DLGG) in up to 70–90% of cases.

Seizure unpredictability is consistently reported as one of the most disabling aspects of living with chronic epilepsy. Reliable forecasting systems could have far-reaching consequences for patients, from allowing protection at times of high seizure risk to improving confidence during everyday life at times of low seizure risk.

Patients with classic orthostatic hypotension (cOH) suffer from an abnormally large blood pressure (BP) fall upon standing due to baroreflex dysfunction. cOH, particularly in the absence of BP-lowering drugs, often has a neurogenic cause (neurogenic orthostatic hypotension [nOH]).

Multiple sclerosis (MS) is a chronic, inflammatory, and neurodegenerative disease of the central nervous system, characterised by…

Cerebellar involvement is common in multiple sclerosis (MS),1,2 with pathological evidence of extensive white matter (WM) and…

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease. Underlying genetic pathomechanisms include the C9orf72…