Neurology

A new explainable AI framework improves Parkinson’s disease prediction accuracy while offering clinically interpretable insights for early diagnosis.

Meta-analysis suggests recurrent falls may signal higher dementia risk, supporting earlier monitoring and prevention in older adults. Read more today.

E-cigarette use may increase dementia risk. Learn what this study found about early cognitive effects and why it matters.

Study shows caffeine and mental health are linked, with moderate intake showing the lowest risk in a major UK study.

5.0 T SWI improves brain imaging clarity compared with 3.0 T, enhancing visualisation of cerebral veins and deep grey matter structures in healthy adults.

Researchers find salivary markers for Alzheimer diagnosis show inconsistent accuracy due to variability in collection and processing methods.

Phase 3 trial shows Tavapadon significantly improves motor function in early Parkinson disease with acceptable safety and tolerability.

Researchers found that the prevalence of mental health misinformation ranged from 0% to 56.9%, highlighting substantial variability in content accuracy.

Meta-analysis shows brain age index from sleep EEG predicts dementia risk, supporting its use as an early digital biomarker.

Meta-analysis finds cannabis and tobacco associated with reductions in the amygdala, insula, pallidum, and total grey matter volume.

This long-term study links mentally active sedentary behaviour to reduced dementia risk compared with passive activities in middle aged adults.

New vessel wall MRI detects more supracardiac atherosclerosis plaques than CTA, improving stroke evaluation and identifying embolic sources.

A single administration of SEAD1 into the prefrontal cortex restored disrupted E/I balance and improved synaptic function.

Cluster trial shows TENS improves fibromyalgia pain with meaningful reductions sustained over six months and high patient satisfaction rates.

Large clinical trial shows no improvement in cognitive function from exercise or intensive vascular risk reduction in older adults.

Large UK Biobank study links depression and gut issues to progressive supranuclear palsy risk up to a decade before diagnosis.

Athletes with greater BBB disruption showed worse cognitive performance compared with those with less leakage and with control participants.

Parkinson’s weight loss is increasingly recognised as a key factor in disease progression, linked to frailty, cognitive decline and reduced quality of life.

Young adults with rare spinal AVMs show strong recovery after targeted endovascular treatment, guided by MRI and CT imaging of the lesions.

Persistent Epstein-Barr virus antibody levels may help distinguish multiple sclerosis from similar neuroinflammatory diseases.

After 2 weeks, patients in the adjunctive FMT group demonstrated significantly greater reductions in HAMD-24 scores compared with controls (p=0.048), alongside a higher overall reduction rate (p=0.016).

Across the pooled analysis, tES demonstrated a significant moderate therapeutic effect in reducing OCD severity (standardised mean difference: 0.61; 95% confidence interval: 0.37–0.85; p

New research tracks early Parkinson’s symptoms over three years, showing how daily impacts evolve and highlighting the value of wearable monitoring.

New research links sleep disturbances after paediatric brain injury to behavioural difficulties, suggesting sleep could be an important target for early clinical intervention.

Clinical studies suggest zorevunersen could reduce seizures and improve quality of life for children and adolescents with Dravet syndrome.

Administration of prochlorperazine or CLP-257 (or its prodrug CLP-290), significantly decreased seizure frequency in vivo, providing further evidence that enhancing KCC2 function could stabilise neuronal networks.

Researchers use long-read genome sequencing to uncover hidden autism gene variants, improving understanding of genetic causes and advancing precision diagnostics.

Brain imaging reveals sensory amplification in chronic back pain, partially reversible with pain reprocessing therapy.

Antibiotic-treated mice demonstrated significantly smaller lesion volumes and reduced cell death compared with vehicle-treated controls after repeated injury.

Low dose lithium treatment tested in mild cognitive impairment, offering effect size data for future larger trials.

New deep learning model combining X-ray and MRI data shows promise in increasing efficiency of cervical spondylosis diagnosis.

Shared molecular changes in brain and blood may improve major depressive disorder diagnosis and guide personalised therapies.

A large cohort study links smoking habits to Parkinson’s disease risk and all-cause mortality, showing persistent smokers have lower PD risk but quitting improves survival.

A pilot cluster randomised study in Ireland shows structured sensory intervention is feasible in dementia care, with strong staff engagement and device uptake.

The authors concluded that the time until onset of Alzheimer’s disease symptoms could be estimated using a single blood test within a margin of error that may be acceptable for use in clinical trials.

Long-term ublituximab treatment reduces relapse rates and disability progression, reinforcing early intervention strategies in multiple sclerosis care.

Heavy cannabis use linked to reduced brain activation during memory tasks, raising concerns about lasting cognitive health effects.

This study shows that brain age as a biomarker may help diagnose mental disorders earlier, and guide more personalised psychiatric treatment.

New study links semaglutide to rare optic nerve damage, highlighting the need for increased awareness, monitoring, and informed prescribing.

A large prospective study in JAMA finds higher caffeinated coffee and tea intake is associated with lower dementia risk and modestly better cognitive function over decades of follow-up.

National data show cumulative lead exposure may triple Alzheimer’s risk and account for 18% of dementia cases annually.

Long-term trial data suggest speed-based cognitive training with boosters may reduce the risk of dementia diagnosis years later.

A UK trial suggests a ketogenic diet may modestly improve symptoms in treatment-resistant depression, but adherence remains a challenge.

New research links psychotic experiences to early brain ageing, offering clues about psychosis risk in young adults.

Study shows non-brain diseases such as diabetes, hearing loss, and liver disease, account for nearly one-third of dementia cases worldwide.

Cumulative psychosocial stress across childhood and adulthood is linked to higher dementia and stroke risk, partly driven by depression.

Long-term Framingham data show traumatic brain injury in older adults, often caused by falls, is linked to higher dementia-related mortality, with risk rising alongside injury severity.

New imaging evidence shows altered brain networks during cognitive effort in chronic fatigue syndrome and long COVID patients.

New imaging data reveal striking sex differences in Alzheimer’s disease biomarkers, with implications for diagnosis and personalised dementia care.

Notably, higher ventral tegmental area (VTA) activation, but not nucleus accumbens or control region activity, correlated with larger post-vaccination increases in HBV antibody levels (r=0.31, P=0.018)

Discover why deep brain stimulation may be safer than expected and how large scale data could change surgical decision making.

A nationwide Swedish study links long-term air pollution exposure to increased motor neuron disease risk and poorer outcomes.

Long-term trial data show vagus nerve stimulation sustains and even increases benefits for patients with severe treatment resistant depression.

When combined with conventional MEP data, the model achieved 83.3% overall accuracy and 82.3% balanced accuracy in identifying MDD.

Find out how maternal diabetes and birth size may shape multiple sclerosis risk decades later in adulthood across large national cohorts.

A nationwide study reveals that pregnancy acid-suppressive medication does not increase children neuropsychiatric disorder risk over time.