News

A six factor prognostic score predicts survival in CML blast phase, enabling improved risk stratification and comparison across clinical studies.

In a mouse model of allergic rhinitis, even a very low dose (0.5 ng) of bryo-1 delivered via anionic LNPs increased antigen-specific IgA levels in salivary secretions.

Study finds indoor air pollution peaks in respiratory patients are driven by daily activities like cooking, often exceeding WHO guidelines.

Greater fitness and healthier body composition are linked to improved chemotherapy tolerance in breast cancer, with limited impact on treatment response.

WHO recommends new tuberculosis testing tools, including near point-of-care tests, tongue swabs, and sputum pooling to improve diagnosis and access.

Normothermic machine perfusion allows clinicians to assess high-risk livers from donors after circulatory or brain death before transplantation.

Synthetic radiographs are often hard to distinguish from real X-rays, challenging radiologists and AI while offering training and research opportunities.

Children with metabolically healthy obesity still face increased cardiometabolic risks by adulthood, highlighting the need for early intervention.

A classifier trained on pre-diagnostic activity and heart rate metrics demonstrated strong discriminatory ability, distinguishing patients with IPAH from controls with a ROC AUC of 0.87.

A real-world study shows transperineal prostate biopsy matches cancer detection rates while reducing infection risk compared to transrectal biopsy.

Physicians specialising in sickle cell disease report higher burnout, driven by reduced recreation and job satisfaction despite similar resilience levels.

While treatment costs were higher – A$3956 for PPOIT and A$3582 for OIT versus A$249 for no treatment – these were offset by improved clinical outcomes.

Ultra-processed food intake around conception may affect fertility in men and early embryo growth in women, according to new research.

The findings showed that videos produced by non-healthcare creators consistently achieved significantly greater numbers of reshares (p=0.0050), favourites (p=0.0495), and overall engagement rates (p=0.0014).

Longer antibiotic courses for acne raise recurrence and resistance risk without improving short-term outcomes, new real-world data show.

Large UK Biobank study links depression and gut issues to progressive supranuclear palsy risk up to a decade before diagnosis.

AI driven MRI analysis improves detection of clinically significant prostate cancer, offering higher diagnostic accuracy than traditional approaches.

Scientists have discovered a previously unknown neural pathway behind the antidiabetic effects of metformin, a standard first-line treatment for Type 2 diabetes.

Sudan faces an outbreak of acute hepatitis among displaced populations, with severe liver complications in vulnerable communities.

IVUS guidance reduces costs and rehospitalisations in lower limb venous stenting, with mixed effects for thrombectomy and thrombolysis procedures.

Discontinuation of, or interruptions to, GLP-1 treatment may increase the risk of major adverse cardiovascular events in adults with Type 2 diabetes.

Autoantibody expression after paediatric stem cell transplantation reflects immune reconstitution rather than chronic graft versus host disease risk, highlighting alternative biomarkers.

Athletes with greater BBB disruption showed worse cognitive performance compared with those with less leakage and with control participants.

A machine learning approach reveals structural HLA biomarkers linked to graft failure, offering a new strategy for donor selection in transplantation.