A RECENT study has explored whether aerobic-emphasised (AE) or resistance-emphasised (RE) exercise is more effective in supporting men undergoing androgen deprivation therapy (ADT) and radiation therapy (RT) for prostate cancer.
ADT combined with RT is a common treatment approach for intermediate and high-risk prostate cancer, particularly among older men or those with additional health concerns. While this combination can be as effective as surgery, it often leads to significant side effects, including fatigue, loss of muscle mass, cardiovascular issues, and metabolic dysfunction.
With a growing population of men living longer after prostate cancer treatment, managing the adverse effects of therapy is a public health priority. Exercise has shown potential to mitigate many of these side effects, but most prior studies have not directly compared AE and RE exercise approaches.
This study aimed to evaluate the feasibility of a 24-week intervention comparing AE and RE programmes, both incorporating high and moderate intensity sessions. The study found that retention, attendance, and adherence were high in both groups, with over 90% session attendance. Importantly, no serious adverse events were reported, though minor exercise modifications were occasionally required due to arthritis.
However, recruitment proved difficult, with only 19% of eligible patients participating, largely due to travel challenges. This suggests future studies should consider multiple recruitment sites or remote exercise options.
Preliminary outcomes indicated that AE may improve haemoglobin levels, possibly counteracting ADT- and RT-induced reductions, and showed better scores for physical functioning. In contrast, RE participants demonstrated better balance outcomes. Both groups improved equally in cardiovascular and strength assessments, with no significant differences in lean mass gains.
Although not powered to detect definitive outcome differences, this study is the first to show that both AE and RE interventions can be safely and effectively delivered during ADT and RT. The findings justify a larger trial, which will need to account for logistical barriers and explore the physiological and quality of life benefits of tailored exercise prescriptions for men with prostate cancer.
Reference
Murphy K et al. Comparing aerobic and resistance exercise emphasis during androgen deprivation and radiation therapy for prostate cancer: A randomised feasibility trial. Support Care Cancer. 2025;33(7):601.
