RECENT RESEARCH has revealed a striking connection between early-life stress and psoriasis development, suggesting that psychological distress experienced in childhood may shape immune function and influence the onset of autoimmune diseases years later. Psoriasis, a chronic inflammatory autoimmune skin condition, arises from a complex interaction between genetic predisposition and environmental triggers. Over 80 psoriasis susceptibility loci have been identified through genome-wide association studies, confirming its strong genetic basis. However, environmental factors such as nutrition, infections, smoking, alcohol, and certain medications like lithium have also been found to play key roles.
The Role of Early-Life Stress in Immune Dysregulation
Drawing on the All Babies in Southeast Sweden birth-cohort, this new study examined whether stressful life factors (SLF) in early childhood increase the likelihood of developing psoriasis later in life. Earlier findings from the same cohort revealed that SLF can trigger diabetes-related autoantibodies and heighten the risk of Type 1 diabetes, hinting at a broader connection between early-life stress and immune dysregulation.
The study found that children who experienced family disruptions, such as divorce or separation, during their first years of life were more likely to develop psoriasis as they grew older. These stressful events appear to activate the body’s hypothalamic–pituitary–adrenal (HPA) axis, elevating cortisol levels and altering immune responses. Such changes can lead to chronic inflammation and immune imbalance, both hallmarks of psoriasis.
Psychological Contact, Nutrition, and Long-Term Protection
Interestingly, previous research from the same team showed that breastfeeding may protect against psoriasis, potentially by fostering psychological security and supporting a healthy gut microbiome. This reinforces the idea that emotional stability and early nurturing play vital roles in immune development.
In summary, this study adds to growing evidence that early-life stress and psoriasis development are closely linked through the body’s stress-response systems. While genetics remain an important factor, these findings highlight the need for emotional support and family stability during a child’s early years to help reduce future autoimmune risk.
Reference
Das D, Ludvigsson J. Early childhood stress and the risk of developing psoriasis: a cohort study. J Invest Dermatol. 2025;DOI:10.1016/j.jid.2025.08.026.
